Protein Overview: eat-2

General Information:
Name(s) found:	eat-2 / CE22119 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00001133 locus:eat-2 Neuronal acetylcholine receptor subunit eat-2 status:Partially_confirmed UniProt:Q9U298 protein_id:CAB54450.1 [WormBase] pir\|\|T27006 hypothetical protein Y48B6A.4 - Caenorhabditis elegans [NCBI NR] gi\|75025400\|sp\|Q9U298.1\|ACH8_CAEEL RecName: Full=Neuronal acetylcholine receptor subunit eat-2; AltName: Full=Abnormal pharyngeal pumping eat-2; Flags: Precursor [NCBI NR] gi\|5824807\|emb\|CAB54450.1\| C. elegans protein Y48B6A.4, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|17537185\|ref\|NP_496959.1\| EATing: abnormal pharyngeal pumping family member (eat-2) [Caenorhabditis elegans] [NCBI NR] Neuronal acetylcholine receptor subunit eat-2 OS=Caenorhabditis elegans GN=eat-2 PE=2 SV=1 [Swiss-Prot] [wormpep67.fasta] CE22119 WBGene00001133 locus:eat-2 status:Partially_confirmed TR:Q9U298 protein_id:CAB54450.1 [wormpep150.fasta] 22119 WBGene00001133 locus:eat-2 status:Partially_confirmed TR:Q9U298 protein_id:CAB54450.1 [wormpep130-phg-ecoli-orf-rand.fasta] EATing: abnormal pharyngeal pumping EAT-2, nicotinic Acetylcholine receptor Dalpha5 family member (55.0 kD) (eat-2) [Caenorhabditis elegans]gi\|5824807\|emb\|CAB54450.1\| Hypothetical protein Y48B6A.4 [Caenorhabditis elegans]gi\|7509979\|pir\|\|T27006 hypotheti [nrdb_11152004_Chlamydomonas] locus:eat-2 status:Partially_confirmed TR:Q9U298 protein_id:CAB54450.1 [wormpep115.fasta.reversed] CE22119 status:Partially_confirmed TR:Q9U298 protein_id:CAB54450.1 [wormpep80.hongbin] CE22119 WBGene00001133 locus:eat-2 status:Partially_confirmed UniProt:Q9U298 protein_id:CAB54450.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE22119 WBGene00001133 locus:eat-2 status:Partially_confirmed UniProt:Q9U298 protein_id:CAB54450.1\| [wormORF-contam.fasta] Hypothetical protein Y48B6A.4 [Caenorhabditis elegans] [nr-271106-contam.fasta] EATing: abnormal pharyngeal pumping family member (eat-2) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE22119 WBGene00001133 locus:eat-2 status:Partially_confirmed UniProt:Q9U298 protein_id:CAB54450.1 Neuronal acetylcholine receptor subunit eat-2 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	474 amino acids
Gene Ontology:
Cellular Component:	postsynaptic membrane [IEA] membrane [IEA] integral to membrane [IEA] neuromuscular junction [IDA]
Biological Process:	regulation of pharyngeal pumping [IGI][IMP ] ion transport [IEA] neuromuscular synaptic transmission [IEP] nematode larval development [IMP] embryonic development ending in birth or egg hatching [IMP] regulation of action potential [IMP] transport [IEA] growth [IMP]
Molecular Function:	neurotransmitter receptor activity [IEA] extracellular ligand-gated ion channel activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLKIAFFTL ILLVSIERVY SSDEEYRLLK DLREGYDPVE RPVADHRKPV NVKLRLILQQ  60
   61 LVDVDERNQV ITLVVWNQYT WNDYKLRWSP EEYGNITTLQ IPHGTLWKPD ILLFNSANEH 120
  121 FDASFPVHMV VSSNGDVLFA PPGIVSFSCS LSMTWFPYDQ QVCYLKFGSW TYGKKLDLQI 180
  181 DDSDLPDGHK MDLQYYIPNG EFDLLATPAF RKSTTFLDET YVELYFHMHL KRRTMYYGLN 240
  241 WIVPSILISL SNILGFTMPP ECGEKITLQI TNFLSVMVFL AMVSEVAPPT SESIPIIAAF 300
  301 FSLSIVILGL SICASLIIVN IFFRHPKTHR MGDWTRYVFL EWLPWFLLMS RPEHTFCRPR 360
  361 REEEKNDEEA GGDGTKLLEN QQHQPRPRLL VNSQLVMDST VPYLEEIIGY LKVFKAKLDD 420
  421 DEEEEEEILN WRFMAMVIDR LSLFLFTGLI FGTTALIFAF CPNLFTDSPI VDIE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
acetylcholine binding	13.9752632471881	bayes_pls_golite062009
acetylcholine receptor activity	13.7533645836795	bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity	13.1511875247796	bayes_pls_golite062009
metal ion transmembrane transporter activity	11.9525876011069	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	11.7813202122163	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	11.7813202122163	bayes_pls_golite062009
cation channel activity	11.7442066737514	bayes_pls_golite062009
ion channel activity	11.1753684044644	bayes_pls_golite062009
passive transmembrane transporter activity	11.0903806681397	bayes_pls_golite062009
channel activity	11.0903806681397	bayes_pls_golite062009
gated channel activity	11.0397691626728	bayes_pls_golite062009
substrate-specific channel activity	10.9375522860542	bayes_pls_golite062009
ligand-gated channel activity	9.34902726749692	bayes_pls_golite062009
ligand-gated ion channel activity	9.34902726749692	bayes_pls_golite062009
amine binding	9.11982124959723	bayes_pls_golite062009
chloride channel regulator activity	9.10587892909341	bayes_pls_golite062009
ion transmembrane transporter activity	7.22265353460749	bayes_pls_golite062009
cation transmembrane transporter activity	7.19173677417054	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	6.7875346065164	bayes_pls_golite062009
transmembrane receptor activity	5.4080353535498	bayes_pls_golite062009
receptor activity	5.11329651194787	bayes_pls_golite062009
transporter activity	5.11262082564788	bayes_pls_golite062009
transmembrane transporter activity	5.03439798256257	bayes_pls_golite062009
substrate-specific transporter activity	4.91314874981447	bayes_pls_golite062009
neurotransmitter binding	4.25797760547212	bayes_pls_golite062009
neurotransmitter receptor activity	4.15404686068319	bayes_pls_golite062009
signal transducer activity	4.12549692767753	bayes_pls_golite062009
molecular transducer activity	4.12549692767753	bayes_pls_golite062009
adenylate cyclase binding	3.30190657223613	bayes_pls_golite062009
binding	2.4916526322278	bayes_pls_golite062009
beta-amyloid binding	2.25766805801029	bayes_pls_golite062009
	1.68370717591127	bayes_pls_golite062009
channel regulator activity	1.66978990310631	bayes_pls_golite062009
protein binding	1.45740893920165	bayes_pls_golite062009
G-protein coupled receptor activity	1.42422063123689	bayes_pls_golite062009
serotonin binding	1.33584589886834	bayes_pls_golite062009
serotonin-activated cation-selective channel activity	1.31324203158511	bayes_pls_golite062009
toxin binding	1.03329843925063	bayes_pls_golite062009
drug binding	0.64715018605883	bayes_pls_golite062009
kinase binding	0.365355763029699	bayes_pls_golite062009
protein kinase binding	0.350601457777817	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..350]	PSI-BLAST	74.69897	Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
2	View Details	[351..474]	PSI-BLAST	37.0	Acetylcholine receptor protein, beta chain

Protein Overview: eat-2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: