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Protein Overview: frs-2

General Information:
Name(s) found: frs-2 / CE20708 [WormBase]
Description(s) found:
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  • WBGene00001498 locus:fars-3 Phenylalanine--tRNA ligase beta subunit status:Confirmed UniProt:Q19713 protein_id:CAA90360.1 [WormBase]
  • pir||T21245 hypothetical protein F22B5.9 - Caenorhabditis elegans [NCBI NR]
  • gi|3876233|emb|CAA90360.1| C. elegans protein F22B5.9, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17533403|ref|NP_495785.1| phenylalanyl (F) tRNA Synthetase family member (frs-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|12229986|sp|Q19713.2|SYFB_CAEEL RecName: Full=Phenylalanyl-tRNA synthetase beta chain; AltName: Full=Phenylalanine--tRNA ligase beta chain; Short=PheRS [NCBI NR]
  • Phenylalanine--tRNA ligase beta subunit OS=Caenorhabditis elegans GN=frs-2 PE=3 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE20708 WBGene00001498 locus:frs-2 phenylalanyl-tRNA synthetase status:Confirmed SW:Q19713 protein_id:CAA90360.1 [wormpep150.fasta]
  • 20708 WBGene00001498 locus:frs-2 phenylalanyl-tRNA synthetase status:Confirmed SW:Q19713 protein_id:CAA90360.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • phenylalanyl (F) tRNA Synthetase (66.1 kD) (frs-2) [Caenorhabditis elegans]gi|3876233|emb|CAA90360.1| Hypothetical protein F22B5.9 [Caenorhabditis elegans]gi|7499637|pir||T21245 hypothetical protein F22B5.9 - Caenorhabditis elegansgi|12229986|sp|Q19713 [nrdb_11152004_Chlamydomonas]
  • locus:frs-2 phenylalanyl-tRNA synthetase status:Partially_confirmed SW:Q19713 protein_id:CAA90360.1 [wormpep115.fasta.reversed]
  • CE20708 locus:frs-2 phenylalanyl-tRNA synthetase status:Partially_confirmed SW:Q19713 protein_id:CAA90360.1 [wormpep80.hongbin]
  • CE20708 WBGene00001498 locus:frs-2 phenylalanyl-tRNA synthetase status:Confirmed UniProt:SYFB_CAEEL protein_id:CAA90360.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE20708 WBGene00001498 locus:frs-2 phenylalanyl-tRNA synthetase status:Confirmed UniProt:SYFB_CAEEL protein_id:CAA90360.1| [wormORF-contam.fasta]
  • phenylalanyl (F) tRNA Synthetase family member (frs-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS) [nr-271106-contam.fasta]
  • Hypothetical protein F22B5.9 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE20708 WBGene00001498 locus:frs-2 phenylalanyl-tRNA synthetase status:Confirmed UniProt:Q19713 protein_id:CAA90360.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE20708 WBGene00001498 locus:fars-3 phenylalanyl-tRNA synthetase status:Confirmed UniProt:Q19713 protein_id:CAA90360.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE20708 WBGene00001498 locus:fars-3 status:Confirmed UniProt:Q19713 protein_id:CAA90360.1 Phenylalanine--tRNA ligase beta subunit [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 591 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    phenylalanyl-tRNA aminoacylation [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    phenylalanine-tRNA ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTVGIKKVI LDKHFKRVYS EKEFDELCFE YGLELDEITS EKAAVEKEQG TRAASDLNDQ  60
   61 EVYKIDIPAN RYDLLSVEGL ARAIRIFKQE IPSPAYKYAD VPKTGLQKII VKKETAQVRP 120
  121 FVVGAVLRDI SFDADSYASF IDLQDKLHQN ICRKRTLVAI GTHDLDTIQG PFEYRAEAPK 180
  181 DIKFKPLNQT KEYTAEELMT LYSTDSHLKA YLPIIQNHPV YPVIYDKNGV VCSMPPIING 240
  241 EHSKITLNTK NVFIEATATD KQKAFVVLDT IVTLFSQYCA KPFTIEQVEV VYEETGVKEL 300
  301 YPLLSYREMT VTTPEINTKI GINLKDEEMA TLLNKMSLKA EVAAKETLKI VVPPTRHDIL 360
  361 HACDIAEDVG VAFGYNNLIT KLPESNTVAV AFPINKLCDN LRIEIAAAGW TEALNFALCS 420
  421 RDDISSKLRQ PDALSHAVHI GNPKTLEFQV ARTSLLPGLL KTLSSNRDMP LPLKLFELQD 480
  481 VIVKDSNTDV GARNERRLAA VYYNRAAGFE IIQGFLDRIM RMLNVNPARD GTGYYIEADE 540
  541 NSTYFPGRCA KIIGPKGVVL GHIGALHPEV ITSFGLTLPC GAVEINVEPF L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..591] PSI-BLAST 111.0 Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phenylalanine-tRNA ligase activity
    		•  13.8919118344182 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  12.5698315343202 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  12.5698315343202 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  12.5592545638101 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.90150581291897 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.61548498770105 bayes_pls_golite062009
  • structural molecule activity
    		•  2.54582212334303 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.07594942154162 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.973820663472435 bayes_pls_golite062009
  • binding
    		•  0.951197041515827 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.864670700044417 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.702449673647117 bayes_pls_golite062009
  • DNA binding
    		•  0.621789297870471 bayes_pls_golite062009
  • nuclease activity
    		•  0.29926900436997 bayes_pls_golite062009
  • transcription factor activity
    		•  0.265631643816467 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.21650406007586 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle