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View Structure Prediction Details

Protein: frs-2
Organism: Caenorhabditis elegans
Length: 591 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for frs-2.

Description E-value Query
Range
Subject
Range
SYFB_SHIFL - Phenylalanine--tRNA ligase beta subunit OS=Shigella flexneri GN=pheT PE=3 SV=1
gi|110615025, gi... - gi|110805477|ref|YP_688997.1| phenylalanyl-tRNA synthetase subunit beta [Shigella flexneri 5 str. 84...
gi|24112891, gi|... - gi|24112891|ref|NP_707401.1| phenylalanyl-tRNA synthetase subunit beta [Shigella flexneri 2a str. 30...
gi|30063020, gi|... - gi|30063020|ref|NP_837191.1| phenylalanyl-tRNA synthetase subunit beta [Shigella flexneri 2a str. 24...
522.0 [0..3] [590..96]

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Predicted Domain #1
Region A:
Residues: [1-591]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTVGIKKVI LDKHFKRVYS EKEFDELCFE YGLELDEITS EKAAVEKEQG TRAASDLNDQ  60
   61 EVYKIDIPAN RYDLLSVEGL ARAIRIFKQE IPSPAYKYAD VPKTGLQKII VKKETAQVRP 120
  121 FVVGAVLRDI SFDADSYASF IDLQDKLHQN ICRKRTLVAI GTHDLDTIQG PFEYRAEAPK 180
  181 DIKFKPLNQT KEYTAEELMT LYSTDSHLKA YLPIIQNHPV YPVIYDKNGV VCSMPPIING 240
  241 EHSKITLNTK NVFIEATATD KQKAFVVLDT IVTLFSQYCA KPFTIEQVEV VYEETGVKEL 300
  301 YPLLSYREMT VTTPEINTKI GINLKDEEMA TLLNKMSLKA EVAAKETLKI VVPPTRHDIL 360
  361 HACDIAEDVG VAFGYNNLIT KLPESNTVAV AFPINKLCDN LRIEIAAAGW TEALNFALCS 420
  421 RDDISSKLRQ PDALSHAVHI GNPKTLEFQV ARTSLLPGLL KTLSSNRDMP LPLKLFELQD 480
  481 VIVKDSNTDV GARNERRLAA VYYNRAAGFE IIQGFLDRIM RMLNVNPARD GTGYYIEADE 540
  541 NSTYFPGRCA KIIGPKGVVL GHIGALHPEV ITSFGLTLPC GAVEINVEPF L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 111.0
Match: 1b70B
Description: Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phenylalanine-tRNA ligase activity 13.8919118344182 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 12.5698315343202 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 12.5698315343202 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 12.5592545638101 bayes_pls_golite062009
ligase activity 6.92073480193262 bayes_pls_golite062009
structural constituent of ribosome 2.90150581291897 bayes_pls_golite062009
glycine-tRNA ligase activity 2.61548498770105 bayes_pls_golite062009
structural molecule activity 2.54582212334303 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
serine-tRNA ligase activity 2.07594942154162 bayes_pls_golite062009
catalytic activity 1.99372273395202 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
histidine-tRNA ligase activity 1.72215103383322 bayes_pls_golite062009
translation initiation factor activity 1.27539679024898 bayes_pls_golite062009
transcription regulator activity 0.973820663472435 bayes_pls_golite062009
binding 0.951197041515827 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
nucleic acid binding 0.864670700044417 bayes_pls_golite062009
ribonuclease activity 0.702449673647117 bayes_pls_golite062009
DNA binding 0.621789297870471 bayes_pls_golite062009
nuclease activity 0.29926900436997 bayes_pls_golite062009
transcription factor activity 0.265631643816467 bayes_pls_golite062009
sequence-specific DNA binding 0.21650406007586 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle