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Protein Overview: cyn-3

General Information:
Name(s) found: cyn-3 / CE20374 [WormBase]
Description(s) found:
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  • WBGene00000879 locus:cyn-3 Peptidyl-prolyl cis-trans isomerase 3 status:Confirmed UniProt:P52011 protein_id:CAA21762.1 [WormBase]
  • gi|9257006|pdb|1DYW|A Chain A, Biochemical And Structural Characterization Of A Divergent Loop Cyclophilin From Caenorhabditis Elegans [NCBI NR]
  • pir||T27373 peptidylprolyl isomerase (EC 5.2.1.8) Y75B12B.5 [similarity] - Caenorhabditis elegans [NCBI NR]
  • gi|3881312|emb|CAA21762.1| C. elegans protein Y75B12B.5, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17559074|ref|NP_506751.1| CYclophyliN family member (cyn-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|1706248|sp|P52011.1|CYP3_CAEEL RecName: Full=Peptidyl-prolyl cis-trans isomerase 3; Short=PPIase; Short=Rotamase; AltName: Full=Cyclophilin-3 [NCBI NR]
  • gi|15988249|pdb|1E8K|A Chain A, Cyclophilin 3 Complexed With Dipeptide Ala-Pro [NCBI NR]
  • gi|11514370|pdb|1E3B|A Chain A, Cyclophilin 3 From C.Elegans Complexed With Aup(Et)3 [NCBI NR]
  • gi|1109668|gb|AAC47129.1| cyclophilin isoform 3 [NCBI NR]
  • Peptidyl-prolyl cis-trans isomerase 3 OS=Caenorhabditis elegans GN=cyn-3 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE20374 WBGene00000879 locus:cyn-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed SW:P52011 protein_id:CAA21762.1 [wormpep150.fasta]
  • 20374 WBGene00000879 locus:cyp-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed SW:P52011 protein_id:CAA21762.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CYcloPhilin, peptidyl-prolyl cis-trans isomerase (18.6 kD) (cyp-3) [Caenorhabditis elegans]gi|3881312|emb|CAA21762.1| Hypothetical protein Y75B12B.5 [Caenorhabditis elegans]gi|15988249|pdb|1E8K|A Chain A, Cyclophilin 3 Complexed With Dipeptide Ala-Prog [nrdb_11152004_Chlamydomonas]
  • CE20374 WBGene00000879 locus:cyp-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed SW:P52011 protein_id:CAA21762.1 [wormpep132.fasta]
  • 20374 WBGene00000879 locus:cyn-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed SW:P52011 protein_id:CAA21762.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:cyp-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed SW:P52011 protein_id:CAA21762.1 [wormpep115.fasta.reversed]
  • CE20374 locus:cyp-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed SW:P52011 protein_id:CAA21762.1 [wormpep80.hongbin]
  • CE20374 WBGene00000879 locus:cyn-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed UniProt:P52011 protein_id:CAA21762.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE20374 WBGene00000879 locus:cyn-3 Peptidyl-prolyl cis-trans isomerases status:Confirmed UniProt:P52011 protein_id:CAA21762.1| [wormORF-contam.fasta]
  • cyclophilin isoform 3 [nr-271106-contam.fasta]
  • Chain A, Cyclophilin 3 From C.Elegans Complexed With Aup(Et)3 [nr-271106-contam.fasta]
  • Chain A, Biochemical And Structural Characterization Of A Divergent Loop Cyclophilin From Caenorhabditis Elegans [nr-271106-contam.fasta]
  • Peptidyl-prolyl cis-trans isomerase 3 (PPIase) (Rotamase) (Cyclophilin-3) [nr-271106-contam.fasta]
  • CYclophyliN family member (cyn-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Chain A, Cyclophilin 3 Complexed With Dipeptide Ala-Pro [nr-271106-contam.fasta]
  • Hypothetical protein Y75B12B.5 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE20374 WBGene00000879 locus:cyn-3 status:Confirmed UniProt:P52011 protein_id:CAA21762.1 Peptidyl-prolyl cis-trans isomerase 3 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 173 amino acids

    Gene Ontology:
    Cellular Component: cell [IDALink to PubMed article]
    Biological Process: protein folding [IEALink to PubMed article][ISSLink to PubMed article]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRSKVFFDI TIGGKASGRI VMELYDDVVP KTAGNFRALC TGENGIGKSG KPLHFKGSKF  60
   61 HRIIPNFMIQ GGDFTRGNGT GGESIYGEKF PDENFKEKHT GPGVLSMANA GPNTNGSQFF 120
  121 LCTVKTEWLD GKHVVFGRVV EGLDVVKAVE SNGSQSGKPV KDCMIADCGQ LKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 66.39794 Cyclophilin (eukaryotic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.46018233647024 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.130251391659493 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle