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Protein Overview: twk-42

General Information:
Name(s) found: twk-42 / CE16550 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00006692 locus:twk-42 status:Confirmed UniProt:O45891 protein_id:CAB04923.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: potassium ion transport [IEALink to PubMed article]
    Molecular Function: potassium channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFWNLVAVNY ERYHLHHLVK IGVLIVYSFL GAGLFVLCEA ENEKSLKHED NMRVLRTSIA  60
   61 AKQVFVQRLQ NMYSGNGSSS EFSETKLRRV LSEYDAAMGI SIDSKMKTRW DIWGGLYYAG 120
  121 TIYTTIGYGD LAAETIWGRI CTMLYAMIGI PIVINILNDW GNMLFYFVDH FWQNIGRQWI 180
  181 QSLRQKLRRR KVQSLEEGSI DKTPLMETSS TPPSPQNPNG TRPIPLLLVL IVLFFWMIQC 240
  241 VAYFAYFENW TLFESVYFFF ISMTTIGFGD FTPSHTVAVG GIVFILGGLS VVSMCINVIQ 300
  301 MQLEFIFNQI VQRIENDFKN TLSVAAEESR KKSIGVSEFG SIDPSKKKTM RTDGNVAEKY 360
  361 SENMEMGNKL LMRFMSNHQK KMLNEKFDER AKMRNSGTQT TSQIKVASVQ TAERYEQTWD 420
  421 EDPEEEQPKS RINTRRLYIY NTGE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 28.39794 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    2 View Details [205..362] PSI-BLAST 8.39794 Potassium channel-related protein MthK
    3 View Details [363..444] PSI-BLAST 12.0 No description for 2q0aA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • gated channel activity
    		•  3.02922750313971 bayes_pls_golite062009
  • cation channel activity
    		•  2.94795475328816 bayes_pls_golite062009
  • ion channel activity
    		•  2.92517027953204 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.90797425893528 bayes_pls_golite062009
  • channel activity
    		•  2.90605645481108 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.90605645481108 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  2.46500195029269 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  2.39180319175421 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  2.38401306733581 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  2.12500575522444 bayes_pls_golite062009
  • potassium channel activity
    		•  2.05844710617957 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.04160103714032 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  1.70106533585704 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  1.70106533585704 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.62726569397176 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.59831301460606 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.28878465000518 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.28367401046165 bayes_pls_golite062009
  • transporter activity
    		•  0.976097741742567 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  0.16997695945551 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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