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View Structure Prediction Details

Protein: twk-42
Organism: Caenorhabditis elegans
Length: 444 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for twk-42.

Description E-value Query
Range		 Subject
Range
CNG_ICTPU - Cyclic nucleotide-gated cation channel OS=Ictalurus punctatus PE=2 SV=1
 190.0 [0..62] [444..119]

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Predicted Domain #1
Region A:
Residues: [1-204] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFWNLVAVNY ERYHLHHLVK IGVLIVYSFL GAGLFVLCEA ENEKSLKHED NMRVLRTSIA  60
   61 AKQVFVQRLQ NMYSGNGSSS EFSETKLRRV LSEYDAAMGI SIDSKMKTRW DIWGGLYYAG 120
  121 TIYTTIGYGD LAAETIWGRI CTMLYAMIGI PIVINILNDW GNMLFYFVDH FWQNIGRQWI 180
  181 QSLRQKLRRR KVQSLEEGSI DKTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.39794
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [205-362] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LMETSSTPPS PQNPNGTRPI PLLLVLIVLF FWMIQCVAYF AYFENWTLFE SVYFFFISMT  60
   61 TIGFGDFTPS HTVAVGGIVF ILGGLSVVSM CINVIQMQLE FIFNQIVQRI ENDFKNTLSV 120
  121 AAEESRKKSI GVSEFGSIDP SKKKTMRTDG NVAEKYSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.39794
Match: 1lnqA
Description: Potassium channel-related protein MthK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
gated channel activity 3.02922750313971 bayes_pls_golite062009
cation channel activity 2.94795475328816 bayes_pls_golite062009
ion channel activity 2.92517027953204 bayes_pls_golite062009
substrate-specific channel activity 2.90797425893528 bayes_pls_golite062009
channel activity 2.90605645481108 bayes_pls_golite062009
passive transmembrane transporter activity 2.90605645481108 bayes_pls_golite062009
voltage-gated cation channel activity 2.46500195029269 bayes_pls_golite062009
voltage-gated ion channel activity 2.39180319175421 bayes_pls_golite062009
voltage-gated channel activity 2.38401306733581 bayes_pls_golite062009
voltage-gated potassium channel activity 2.12500575522444 bayes_pls_golite062009
potassium channel activity 2.05844710617957 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.04160103714032 bayes_pls_golite062009
ligand-gated ion channel activity 1.70106533585704 bayes_pls_golite062009
ligand-gated channel activity 1.70106533585704 bayes_pls_golite062009
cation transmembrane transporter activity 1.62726569397176 bayes_pls_golite062009
ion transmembrane transporter activity 1.59831301460606 bayes_pls_golite062009
substrate-specific transporter activity 1.28878465000518 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.28367401046165 bayes_pls_golite062009
transporter activity 0.976097741742567 bayes_pls_golite062009
inward rectifier potassium channel activity 0.16997695945551 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [363-444] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NMEMGNKLLM RFMSNHQKKM LNEKFDERAK MRNSGTQTTS QIKVASVQTA ERYEQTWDED  60
   61 PEEEQPKSRI NTRRLYIYNT GE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 2q0aA
Description: No description for 2q0aA was found.
YRC Informatics Platform - Version 3.0
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