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Protein Overview: usp-14

General Information:
Name(s) found: usp-14 / CE15615 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00006856 locus:usp-14 Ubiquitin carboxyl-terminal hydrolase 14 status:Confirmed UniProt:Q17361 protein_id:CAB03876.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 489 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein modification process [IEALink to PubMed article]
    ubiquitin-dependent protein catabolic process [IEALink to PubMed article]
    Molecular Function: ubiquitin thiolesterase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL GDDDWEGITI  60
   61 KENMTIMMMG SVGEIPKPPT VLEKKQANRD KQAEEISALY PCGLANLGNT CYFNSCVQML 120
  121 KEVNELVLKP AEEMRIREHN DRLCHNLATL FNSLRDKDRA LRSKGEPIKP FAAILTLSDS 180
  181 FPQFEKFKQQ DANECLVSIM SNVTRIYGLS GWNIESLFRI QTETTMKCLE SDEVSEKKVE 240
  241 RNNQLTCYVN QDVRFLQTGI KAGFEEEMTR NSEELNRDAK WQKNTQISRL PKYLTVNINR 300
  301 FFYKESTKTN AKILKSVQFP MQLDTYDLCS QELKDKLVAR RADIKLEEDA KLERELRKKV 360
  361 LDKEQGDKIF DDGVALPTAF EDDAGSNNSG FYDLKGIITH KGRSSQDGHY VAWMRSSEDG 420
  421 KWRLFDDEHV TVVDEEAILK TSGGGDWHSA YVLLYEARVI KQFPELPPAP VPTEVAADTA 480
  481 EPMEVSEKQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] PSI-BLAST 10.30103 Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14)
    2 View Details [83..489] PSI-BLAST 45.522879 Structure of USP14, a proteasome-associated deubiquitinating enzyme

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  3.22676362920771 bayes_pls_golite062009
  • hydrolase activity
    		•  2.77871378503369 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.46621820231139 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.24025972049145 bayes_pls_golite062009
  • binding
    		•  2.19381585790185 bayes_pls_golite062009
  • protein tag
    		•  1.93603588492737 bayes_pls_golite062009
  • protein binding
    		•  1.84908810286528 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.54640383227873 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.58905960362002 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.536856055841234 bayes_pls_golite062009
  • kinase activity
    		•  0.506057697290914 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.410719674374641 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.383121378043805 bayes_pls_golite062009
  • protein kinase activity
    		•  0.325253662829604 bayes_pls_golite062009
  • transferase activity
    		•  0.236208643697075 bayes_pls_golite062009
  • DNA binding
    		•  0.0840213088061073 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0485636215870291 bayes_pls_golite062009
    2
    Term Confidence Notes
  • peptidase activity
    		•  7.38847948226412 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  7.21002260103248 bayes_pls_golite062009
  • endopeptidase activity
    		•  6.57191549077589 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.91394445088241 bayes_pls_golite062009
  • hydrolase activity
    		•  4.82615927403291 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  4.1832081096766 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.96735553959103 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.3276268995308 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.854677025220204 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.495951820083869 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.467924587720185 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439226369799415 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.168761518285256 bayes_pls_golite062009
  • transferase activity
    		•  0.0852393573521809 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle