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Protein Overview: wee-1.3

General Information:
Name(s) found: wee-1.3 / CE14884 [WormBase]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • WBGene00006940 locus:wee-1.3 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 status:Confirmed UniProt:O18209 protein_id:CAB16484.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 677 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: oocyte construction [IMPLink to PubMed article]
    oocyte maturation [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDTEGNSSM DSIRNGQSSP LPQVTPRLPQ IPMMMRETPL STKRERQAIT PRFRRPAPKM  60
   61 IKTMPPTRSI WSVRKESVPL LVTPQGPKPL ESPKYDHTNA QSFFEQVFQI DEIIGRGSFG 120
  121 EVFAARCRED SQLYAVKVSL APIRQHSISK YREAESHMII PPHKNLVKFY RAWEETGRLY 180
  181 IQTELCDQSL LKYCTEKHAL PEDEIWNIFV DLLQAVHHLH SNDMIHDDIK PENIFLTKDM 240
  241 ICKLGDFGLV INLKNPNDVK SAEEGDSKYL APEVLNGRPT KSSDIFSLGM TILEATTDLD 300
  301 VPSNGDSWHQ IRNGQIPDRF FAGISTDLRS LIALMLDSDP RIRPTSRDLL DHPVIKKKLM 360
  361 KRGTYVKCIS ILNGFFYAFS AVLVWVMAFF SVLFHPIVRF HAAIKDRQSE ICAQFVNNQQ 420
  421 HTPIQTPETS KVYLESLTGV AVRQASQIVS PFDFSDDENP PNAQRRLFTG AVPCRLNFDN 480
  481 DQDDDEEQAT CSSSNSSAIE PQLDEPESPP RMNDVIDKLG KRGTPRSARR NLTFNRHRQV 540
  541 AASVAPKSSL NHYNHHTGSG DGFSNNSLIP ISDQERTEKY LRMRLTEQQL DWADQNNVID 600
  601 EAPPPMSCPP RIRRSIRDLP RMPVLNFNVL DEPSNKPTVD HHTILEQSES PRRRLNRGAK 660
  661 PVPRNRMMSF GSSGDEV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 64.0 No description for 2f2uA was found.
    2 View Details [103..545] PSI-BLAST 57.0 G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
    3 View Details [546..677] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.36057410204148 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.19402106948268 bayes_pls_golite062009
  • signal transducer activity
    		•  2.19402106948268 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.63027742934354 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.56273222498928 bayes_pls_golite062009
  • receptor activity
    		•  1.41608387998871 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.27740808551012 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16307073947901 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.1208666000428 bayes_pls_golite062009
  • transporter activity
    		•  1.07717671444596 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.07139311422871 bayes_pls_golite062009
  • DNA binding
    		•  1.02122968429273 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.96468055729151 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.93867354225509 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.913202195807197 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.892190761383429 bayes_pls_golite062009
  • GTPase activity
    		•  0.882015031334975 bayes_pls_golite062009
  • transcription factor activity
    		•  0.825932471558326 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.674782902132236 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.563658782051893 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • tubulin binding
    		•  0.488928950975855 bayes_pls_golite062009
  • actin binding
    		•  0.464111806616899 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.421857062825531 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • microtubule binding
    		•  0.196718452862042 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.121723516604948 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.06299133151516 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.06299133151516 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle