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Protein Overview: app-1

General Information:
Name(s) found: app-1 / CE14560 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00000155 locus:app-1 status:Confirmed UniProt:O44750 protein_id:CCD70128.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 616 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: proteolysis [IEALink to PubMed article]
    creatine metabolic process [IEALink to PubMed article]
    Molecular Function: metalloexopeptidase activity [IEALink to PubMed article]
    creatinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTALEKLAKL RSLFHSERVL ALTSSKPMVA YLLPSTDAHH SEYLADYDFR VKFLSGFSGS  60
   61 NAYVVVTDRE ALLWTDGRYF TQAGNQLDSN SWKLMKQGQP DSITVVDWLV RELERGSVIG 120
  121 FDPTLSTFDA GSKTFKRLKA AGLQPVSIPG NLVDEFWTDR PRLAGEPVVV LDVEDTGLTT 180
  181 SKKVENLREK LKQKKCDAAV FTLLDDVMWL LNIRGSDIPY NPLAYSYLFV AMREIHVFID 240
  241 NEKLDEKSRA HFHKSNVSIH PYGEVYSWIS NWLKAKEASK EPHMVYLTPE TNYAIGSIIG 300
  301 EENSMVDTSL VQTAKATKND HEMQGMRNSH LRDSAALVEF LCWLEKELLS GKRYTEIELA 360
  361 DKIDHLRSLQ DKYVTLSFDT ISAVGDHAAL PHYKPLGESG NRKAAANQVF LLDSGAHYGD 420
  421 GTTDVTRTVW YTNPPKEFIL HNTLVLKGHI NLARAKFPDG IYGSRLDTLT RDALWKLGLD 480
  481 FEHGTGHGVG HYLNVHEGPI GIGHRSVPTG GELHASQVLT IEPGFYAKEK YGIRIENCYE 540
  541 TVEAVVMSKA QNFLTFKSLT LVPIQTSIVD KSLLIEEEIN WLNQYHARVL KEVGEHLQKR 600
  601 GKTDELKWLA EACKPI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] FFAS03 2.75 Creatinase; Creatinase, catalytic (C-terminal) domain
    2 View Details [167..616] PSI-BLAST 74.522879 Prolidase from Pyrococcus furiosus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  2.60615909541559 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3228898238998 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.18503136472662 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09388149606759 bayes_pls_golite062009
  • DNA binding
    		•  1.92799814679615 bayes_pls_golite062009
  • binding
    		•  1.4562583231987 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43646476372001 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22693836163332 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.89399203910285 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.762255574851485 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.629480947971878 bayes_pls_golite062009
  • protein binding
    		•  0.170797254754318 bayes_pls_golite062009
  • catalytic activity
    		•  0.148551873544128 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle