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View Structure Prediction Details

Protein: app-1
Organism: Caenorhabditis elegans
Length: 616 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for app-1.

Description E-value Query
Range
Subject
Range
gi|148725981, gi... - gi|47085707|ref|NP_998145.1| X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [Danio rerio], gi...
561.0 [0..3] [616..6]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTALEKLAKL RSLFHSERVL ALTSSKPMVA YLLPSTDAHH SEYLADYDFR VKFLSGFSGS  60
   61 NAYVVVTDRE ALLWTDGRYF TQAGNQLDSN SWKLMKQGQP DSITVVDWLV RELERGSVIG 120
  121 FDPTLSTFDA GSKTFKRLKA AGLQPVSIPG NLVDEFWTDR PRLAGE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.75
Match: 1chmA
Description: Creatinase; Creatinase, catalytic (C-terminal) domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [167-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVVVLDVEDT GLTTSKKVEN LREKLKQKKC DAAVFTLLDD VMWLLNIRGS DIPYNPLAYS  60
   61 YLFVAMREIH VFIDNEKLDE KSRAHFHKSN VSIHPYGEVY SWISNWLKAK EASKEPHMVY 120
  121 LTPETNYAIG SIIGEENSMV DTSLVQTAKA TKNDHEMQGM RNSHLRDSAA LVEFLCWLEK 180
  181 ELLSGKRYTE IELADKIDHL RSLQDKYVTL SFDTISAVGD HAALPHYKPL GESGNRKAAA 240
  241 NQVFLLDSGA HYGDGTTDVT RTVWYTNPPK EFILHNTLVL KGHINLARAK FPDGIYGSRL 300
  301 DTLTRDALWK LGLDFEHGTG HGVGHYLNVH EGPIGIGHRS VPTGGELHAS QVLTIEPGFY 360
  361 AKEKYGIRIE NCYETVEAVV MSKAQNFLTF KSLTLVPIQT SIVDKSLLIE EEINWLNQYH 420
  421 ARVLKEVGEH LQKRGKTDEL KWLAEACKPI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.522879
Match: 1pv9A
Description: Prolidase from Pyrococcus furiosus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 2.60615909541559 bayes_pls_golite062009
transcription regulator activity 2.3228898238998 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.18503136472662 bayes_pls_golite062009
nucleic acid binding 2.09388149606759 bayes_pls_golite062009
DNA binding 1.92799814679615 bayes_pls_golite062009
binding 1.4562583231987 bayes_pls_golite062009
hydrolase activity 1.43646476372001 bayes_pls_golite062009
transcription factor activity 1.22693836163332 bayes_pls_golite062009
aminopeptidase activity 0.89399203910285 bayes_pls_golite062009
exopeptidase activity 0.762255574851485 bayes_pls_golite062009
metallopeptidase activity 0.629480947971878 bayes_pls_golite062009
protein binding 0.170797254754318 bayes_pls_golite062009
catalytic activity 0.148551873544128 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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