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Protein Overview: dhs-16

General Information:
Name(s) found: dhs-16 / CE08067 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00000979 locus:dhs-16 3 beta-hydroxysteroid dehydrogenase dhs-16 status:Confirmed UniProt:O16881 protein_id:CCD64121.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 388 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: estrogen biosynthetic process [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    Molecular Function: estradiol 17-beta-dehydrogenase activity [IEALink to PubMed article]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    3-hydroxybutyrate dehydrogenase activity [IEALink to PubMed article]
    2-deoxy-D-gluconate 3-dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLELIYILPL LCFVYFLFRR FVLENFYVES SGKYVMITGC DSGFGRLLAT SLLDKHVNVF  60
   61 AACFTQQGMA SLHSEWKLKK GPKGQLYTLQ LDVTSQASVD SAKSFVTKIL KEQNSKLWGL 120
  121 VNNAGIFSIH GPDDWCSVDE YASSLNVNTL GAVRMCHAFV PLIKKSRGRI VTMGSTAGRL 180
  181 HGLYVAPYVT AKFAVEAYMD CLRLEMRPFG VSVHILEPGC FKTELLNNDA QRMRIQKIWN 240
  241 SLSVETKEEY GEDYRNDFER AWEAGVNVVA NPNIGWVVDC YSHALFSWWP RLRYCPGWDA 300
  301 IFMFIPLSIF PTALQDWILA GLYKLNPGPS LTPAVLVKNK KRRSAIQWIQ FLSQIAIIPL 360
  361 LYTIFFVKNT QKQTVETSTH HHNVTVSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 35.39794 HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  4.1750549780559 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  4.06671791262953 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  3.70115036051018 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  3.56748749904419 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • ethanol binding
    		•  2.01597876952325 bayes_pls_golite062009
  • retinol binding
    		•  1.92497267707609 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • retinoid binding
    		•  1.72614743805853 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.61095405873981 bayes_pls_golite062009
  • alcohol binding
    		•  1.51091775360793 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.29098300860169 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.22416351603098 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  1.05577641583555 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.977681939875779 bayes_pls_golite062009
  • all-trans retinal binding
    		•  0.968189751942231 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.955727553358398 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.905392379451071 bayes_pls_golite062009
  • electron carrier activity
    		•  0.851536992751213 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.839863523675468 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.788034697021177 bayes_pls_golite062009
  • 11-beta-hydroxysteroid dehydrogenase activity
    		•  0.617411823427239 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.51503848775098 bayes_pls_golite062009
  • C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
    		•  0.408483170177369 bayes_pls_golite062009
  • transporter activity
    		•  0.386201011167897 bayes_pls_golite062009
  • binding
    		•  0.355184540089764 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.263379781250632 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.261132005311306 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.234886340849206 bayes_pls_golite062009
  • signal transducer activity
    		•  0.220014544038474 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.220014544038474 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.216422278300306 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.15639913603713 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.135469305070471 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.111812117473399 bayes_pls_golite062009
  • receptor activity
    		•  0.0665855982136239 bayes_pls_golite062009
  • ion channel activity
    		•  0.0487923057681532 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0238273626039303 bayes_pls_golite062009
  • gated channel activity
    		•  0.015794644474568 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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