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View Structure Prediction Details

Protein: dhs-16
Organism: Caenorhabditis elegans
Length: 388 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dhs-16.

Description E-value Query
Range		 Subject
Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...
 269.0 [0..28] [282..1]

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Predicted Domain #1
Region A:
Residues: [1-388] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLELIYILPL LCFVYFLFRR FVLENFYVES SGKYVMITGC DSGFGRLLAT SLLDKHVNVF  60
   61 AACFTQQGMA SLHSEWKLKK GPKGQLYTLQ LDVTSQASVD SAKSFVTKIL KEQNSKLWGL 120
  121 VNNAGIFSIH GPDDWCSVDE YASSLNVNTL GAVRMCHAFV PLIKKSRGRI VTMGSTAGRL 180
  181 HGLYVAPYVT AKFAVEAYMD CLRLEMRPFG VSVHILEPGC FKTELLNNDA QRMRIQKIWN 240
  241 SLSVETKEEY GEDYRNDFER AWEAGVNVVA NPNIGWVVDC YSHALFSWWP RLRYCPGWDA 300
  301 IFMFIPLSIF PTALQDWILA GLYKLNPGPS LTPAVLVKNK KRRSAIQWIQ FLSQIAIIPL 360
  361 LYTIFFVKNT QKQTVETSTH HHNVTVSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.39794
Match: 1fdsA
Description: HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 COMPLEXED WITH 17-BETA-ESTRADIOL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
retinol dehydrogenase activity 4.1750549780559 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 4.06671791262953 bayes_pls_golite062009
steroid dehydrogenase activity 3.70115036051018 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.56748749904419 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 2.94416173750168 bayes_pls_golite062009
ethanol binding 2.01597876952325 bayes_pls_golite062009
retinol binding 1.92497267707609 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
retinoid binding 1.72614743805853 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
isoprenoid binding 1.61095405873981 bayes_pls_golite062009
alcohol binding 1.51091775360793 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 1.29098300860169 bayes_pls_golite062009
fatty acid synthase activity 1.23679054027553 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.22416351603098 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 1.05577641583555 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 0.977681939875779 bayes_pls_golite062009
all-trans retinal binding 0.968189751942231 bayes_pls_golite062009
NADPH:quinone reductase activity 0.955727553358398 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.905392379451071 bayes_pls_golite062009
electron carrier activity 0.851536992751213 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.839863523675468 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.788034697021177 bayes_pls_golite062009
11-beta-hydroxysteroid dehydrogenase activity 0.617411823427239 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.604742541607263 bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity 0.532187027260366 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.51503848775098 bayes_pls_golite062009
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity 0.408483170177369 bayes_pls_golite062009
transporter activity 0.386201011167897 bayes_pls_golite062009
binding 0.355184540089764 bayes_pls_golite062009
transmembrane transporter activity 0.263379781250632 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.261132005311306 bayes_pls_golite062009
substrate-specific transporter activity 0.234886340849206 bayes_pls_golite062009
signal transducer activity 0.220014544038474 bayes_pls_golite062009
molecular transducer activity 0.220014544038474 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.216422278300306 bayes_pls_golite062009
enoyl-CoA hydratase activity 0.15639913603713 bayes_pls_golite062009
G-protein coupled receptor activity 0.135469305070471 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.111812117473399 bayes_pls_golite062009
receptor activity 0.0665855982136239 bayes_pls_golite062009
ion channel activity 0.0487923057681532 bayes_pls_golite062009
ion transmembrane transporter activity 0.0238273626039303 bayes_pls_golite062009
gated channel activity 0.015794644474568 bayes_pls_golite062009
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