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Protein Overview: sir-2.1

General Information:
Name(s) found: sir-2.1 / CE06302 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00004800 locus:sir-2.1 NAD-dependent protein deacetylase sir-2.1 status:Partially_confirmed UniProt:Q21921 protein_id:CAA94364.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 607 amino acids

    Gene Ontology:
    Cellular Component: chromatin silencing complex [IEALink to PubMed article]
    Biological Process: determination of adult lifespan [IMPLink to PubMed article]
    protein amino acid deacetylation [IDALink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    chromatin silencing [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    deacetylase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDSGNDSE VAVTHGEVQE ITEENPEIGS MHITQETDIS DAPETNTDSS RQRTESTTSV  60
   61 SSESWQNNDE MMSNLRRAQR LLDDGATPLQ IIQQIFPDFN ASRIATMSEN AHFAILSDLL 120
  121 ERAPVRQKLT NYNSLADAVE LFKTKKHILV LTGAGVSVSC GIPDFRSKDG IYARLRSEFP 180
  181 DLPDPTAMFD IRYFRENPAP FYNFAREIFP GQFVPSVSHR FIKELETSGR LLRNYTQNID 240
  241 TLEHQTGIKR VVECHGSFSK CTCTRCGQKY DGNEIREEVL AMRVAHCKRC EGVIKPNIVF 300
  301 FGEDLGREFH QHVTEDKHKV DLIVVIGSSL KVRPVALIPH CVDKNVPQIL INRESLPHYN 360
  361 ADIELLGNCD DIIRDICFSL GGSFTELITS YDSIMEQQGK TKSQKPSQNK RQLISQEDFL 420
  421 NICMKEKRND DSSDEPTLKK PRMSVADDSM DSEKNNFQEI QKHKSEDDDD TRNSDDILKK 480
  481 IKHPRLLSIT EMLHDNKCVA ISAHQTVFPG AECSFDLETL KLVRDVHHET HCESSCGSSC 540
  541 SSNADSEANQ LSRAQSLDDF VLSDEDRKNT IHLDLQRADS CDGDFQYELS ETIDPETFSH 600
  601 LCEEMRI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] deduced N/A No confident structure predictions are available.
    2 View Details [114..388] PSI-BLAST 68.09691 Sirt2 histone deacetylase
    3 View Details [389..607] MSA 8.149996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein deacetylase activity
    		•  9.15022242957651 bayes_pls_golite062009
  • histone deacetylase activity
    		•  9.04876491350231 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • deacetylase activity
    		•  8.11496387956068 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  6.02509672218091 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  5.83127897351395 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  5.29340754009793 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  4.51070381823692 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.4896257195243 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • histone binding
    		•  1.71445510915336 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • nucleosome binding
    		•  1.5125174755597 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  1.11434618720209 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  0.0099486881187274 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle