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Protein Overview: hlh-2

General Information:
Name(s) found: hlh-2 / CE06191 [WormBase]
Description(s) found:
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  • WBGene00001949 locus:hlh-2 status:Confirmed UniProt:G5EEG9 protein_id:CAA95837.1 [WormBase]
  • pir||T18853 probable transcription factor - Caenorhabditis elegans [NCBI NR]
  • gi|71989325|ref|NP_001021581.1| Helix Loop Helix family member (hlh-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|3878580|emb|CAA95837.1| C. elegans protein M05B5.5a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|3873917|emb|CAA95787.1| C. elegans protein M05B5.5a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_492034.1| helix Loop Helix containing protein, neuronal transcription factor E12/47 homolog, a partner of bHLH LIN-32 and HLH-3 (43.2 kD) (hlh-2) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE06191 WBGene00001949 locus:hlh-2 transcription factor E2-A like status:Confirmed TR:Q17588 protein_id:CAA95837.1 [wormpep150.fasta]
  • 06191 WBGene00001949 locus:hlh-2 transcription factor E2-A like status:Confirmed TR:Q17588 protein_id:CAA95837.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • helix Loop Helix containing protein, neuronal transcription factor E12/47 homolog, a partner of bHLH LIN-32 and HLH-3 (43.2 kD) (hlh-2) [Caenorhabditis elegans]gi|3878580|emb|CAA95837.1| Hypothetical protein M05B5.5a [Caenorhabditis elegans]gi|3873917|e [nrdb_11152004_Chlamydomonas]
  • locus:hlh-2 transcription factor E2-A like status:Confirmed TR:Q17588 protein_id:CAA95837.1 [wormpep115.fasta.reversed]
  • CE06191 locus:hlh-2 transcription factor E2-A like status:Confirmed TR:Q17588 protein_id:CAA95787.1 [wormpep80.hongbin]
  • CE06191 WBGene00001949 locus:hlh-2 transcription factor E2-A like status:Confirmed UniProt:Q17588_CAEEL protein_id:CAA95837.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE06191 WBGene00001949 locus:hlh-2 transcription factor E2-A like status:Confirmed UniProt:Q17588_CAEEL protein_id:CAA95837.1| [wormORF-contam.fasta]
  • Hypothetical protein M05B5.5a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Helix Loop Helix family member (hlh-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE06191 WBGene00001949 locus:hlh-2 transcription factor E2-A like status:Confirmed UniProt:Q17588 protein_id:CAA95837.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE06191 WBGene00001949 locus:hlh-2 transcription factor E2-A like status:Confirmed UniProt:G5EEG9 protein_id:CAA95837.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE06191 WBGene00001949 locus:hlh-2 status:Confirmed UniProt:G5EEG9 protein_id:CAA95837.1 [wormpep246-ecoli-contam.fasta]
  • Helix Loop Helix OS=Caenorhabditis elegans GN=hlh-2 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 399 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: tail morphogenesis [IMPLink to PubMed article]
    positive regulation of vulval development [IMPLink to PubMed article]
    vulval development [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    gonad morphogenesis [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of programmed cell death [IGILink to PubMed article][IMPLink to PubMed article]
    tail tip morphogenesis [IGILink to PubMed article][IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    neuron development [IGILink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IGILink to PubMed articleLink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    regulation of transcription [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    gonad development [IMPLink to PubMed articleLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    cell fate specification [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    neuroblast fate specification [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein homodimerization activity [IPILink to PubMed articleLink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed articleLink to PubMed article]
    transcription regulator activity [IEALink to PubMed article]
    sequence-specific DNA binding [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPNSQLTS ATTVATAAIA QPQVMLPNAY DYPYNIDPTT IQMPDYWSGY HLNPYPPMQT  60
   61 TDIDYSSAFL PTHPPTETPA SVAAPTSATS DIKPIHATSS TSTTAPSTAP APTSTTDVLE 120
  121 LKPTTAPATN SAETSAIVAP QPLTNLTAPI DAMSSMYTWP QTYPGYLPPS EDNKASEAVN 180
  181 PYISIPPTYT FGADPSVADF SSYQQQLAGQ PNGLGGDTNL VDYNHQFPPA GMSPHFDPNG 240
  241 YPGMTGMPPG SSASSVRNDK SASRATSRRR VQGPPSSGIP TRHSSSSRLS DNESMSDDKD 300
  301 TDRRSQNNAR ERVRVRDINS AFKELGRMCT QHNQNTERNQ TKLGILHNAV SVITQLEEQV 360
  361 RQRNMNPKVM AGMKRKPDDD KMKMLDDNAP SAQFGHPRF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179] MSA 3.172991 View MSA. No confident structure predictions are available.
    2 View Details [180..290] MSA 3.173981 View MSA. No confident structure predictions are available.
    3 View Details [291..399] FFAS03 1.82 Myc prot-oncogene protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  3.52515734914199 bayes_pls_golite062009
  • DNA binding
    		•  3.21016883589545 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.15909910956342 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90093125513881 bayes_pls_golite062009
  • binding
    		•  2.29757014970031 bayes_pls_golite062009
  • protein binding
    		•  1.81946124321514 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77806752347571 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.22261023465971 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.09856580825267 bayes_pls_golite062009
  • transcription factor binding
    		•  0.435480522052453 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.194129578991214 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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