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View Structure Prediction Details

Protein: hlh-2
Organism: Caenorhabditis elegans
Length: 399 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hlh-2.

Description E-value Query
Range
Subject
Range
gi|40788981 - gi|40788981|dbj|BAA74928.2| KIAA0905 protein [Homo sapiens]
188.0 [0..10] [373..819]

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Predicted Domain #1
Region A:
Residues: [1-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPNSQLTS ATTVATAAIA QPQVMLPNAY DYPYNIDPTT IQMPDYWSGY HLNPYPPMQT  60
   61 TDIDYSSAFL PTHPPTETPA SVAAPTSATS DIKPIHATSS TSTTAPSTAP APTSTTDVLE 120
  121 LKPTTAPATN SAETSAIVAP QPLTNLTAPI DAMSSMYTWP QTYPGYLPPS EDNKASEAV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [180-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPYISIPPTY TFGADPSVAD FSSYQQQLAG QPNGLGGDTN LVDYNHQFPP AGMSPHFDPN  60
   61 GYPGMTGMPP GSSASSVRND KSASRATSRR RVQGPPSSGI PTRHSSSSRL S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [291-399]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNESMSDDKD TDRRSQNNAR ERVRVRDINS AFKELGRMCT QHNQNTERNQ TKLGILHNAV  60
   61 SVITQLEEQV RQRNMNPKVM AGMKRKPDDD KMKMLDDNAP SAQFGHPRF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.82
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.52515734914199 bayes_pls_golite062009
DNA binding 3.21016883589545 bayes_pls_golite062009
nucleic acid binding 3.15909910956342 bayes_pls_golite062009
transcription factor activity 2.90093125513881 bayes_pls_golite062009
binding 2.29757014970031 bayes_pls_golite062009
protein binding 1.81946124321514 bayes_pls_golite062009
transcription activator activity 1.77806752347571 bayes_pls_golite062009
sequence-specific DNA binding 1.22261023465971 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09856580825267 bayes_pls_golite062009
transcription factor binding 0.435480522052453 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.194129578991214 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle