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Protein Overview: krs-1

General Information:
Name(s) found: krs-1 / CE04861 [WormBase]
Description(s) found:
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  • WBGene00002238 locus:kars-1 Lysine--tRNA ligase status:Confirmed UniProt:Q22099 protein_id:CCD69180.1 [WormBase]
  • pir||T16780 hypothetical protein T02G5.9 - Caenorhabditis elegans [NCBI NR]
  • gi|2501024|sp|Q22099.1|SYK_CAEEL RecName: Full=Lysyl-tRNA synthetase; AltName: Full=Lysine--tRNA ligase; Short=LysRS [NCBI NR]
  • gi|17535927|ref|NP_495453.1| lysyl (K) tRNA Synthetase family member (krs-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|1086773|gb|AAA82396.1| Lysyl (k) trna synthetase protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • Lysine--tRNA ligase OS=Caenorhabditis elegans GN=krs-1 PE=3 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE04861 WBGene00002238 locus:krs-1 lysyl-tRNA synthetase status:Confirmed SW:Q22099 protein_id:AAA82396.1 [wormpep150.fasta]
  • 04861 WBGene00002238 locus:krs-1 lysyl-tRNA synthetase status:Confirmed SW:Q22099 protein_id:AAA82396.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • lysyl (K) tRNA Synthetase (65.1 kD) (krs-1) [Caenorhabditis elegans]gi|1086773|gb|AAA82396.1| Lysyl (k) trna synthetase protein 1, isoform a [Caenorhabditis elegans]gi|7437595|pir||T16780 hypothetical protein T02G5.9 - Caenorhabditis elegansgi|2501024| [nrdb_11152004_Chlamydomonas]
  • locus:krs-1 lysyl-tRNA synthetase status:Confirmed SW:Q22099 protein_id:AAA82396.1 [wormpep115.fasta.reversed]
  • CE04861 locus:krs-1 lysyl-tRNA synthetase status:Confirmed [wormpep80.hongbin]
  • CE04861 WBGene00002238 locus:krs-1 lysyl-tRNA synthetase status:Confirmed UniProt:SYK_CAEEL protein_id:AAA82396.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE04861 WBGene00002238 locus:krs-1 lysyl-tRNA synthetase status:Confirmed UniProt:SYK_CAEEL protein_id:AAA82396.1| [wormORF-contam.fasta]
  • lysyl (K) tRNA Synthetase family member (krs-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Lysyl (k) trna synthetase protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Lysyl-tRNA synthetase (Lysine--tRNA ligase) (LysRS) [nr-271106-contam.fasta]
  • CE04861 WBGene00002238 locus:krs-1 lysyl-tRNA synthetase status:Confirmed UniProt:Q22099 protein_id:AAA82396.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE04861 WBGene00002238 locus:kars-1 lysyl-tRNA synthetase status:Confirmed UniProt:Q22099 protein_id:CCD69180.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE04861 WBGene00002238 locus:kars-1 status:Confirmed UniProt:Q22099 protein_id:CCD69180.1 Lysine--tRNA ligase [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    asparaginyl-tRNA aminoacylation [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    lysyl-tRNA aminoacylation [IEALink to PubMed article]
    aspartyl-tRNA aminoacylation [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed article]
    translation [IEALink to PubMed article]
    tRNA aminoacylation for protein translation [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    nucleic acid binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    aminoacyl-tRNA ligase activity [IEALink to PubMed article]
    lysine-tRNA ligase activity [IEALink to PubMed article]
    asparagine-tRNA ligase activity [IEALink to PubMed article]
    aspartate-tRNA ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPEAKLSK NEQKRLAKQA KKEQERLEKD AAKLNVAVAD APKVVREADP SDPQEYFNMR  60
   61 VRMIEARRAA GDNPFPHKFN VTISLTDFIT KYTPLEKEQV VEEIVSVAGR IHSKRESGSK 120
  121 LVFYDIHGEG THIQIMANAK FHTGDVDFVT LHDRIKRGDI VGFTGRATRT KAGELSLIPN 180
  181 EILQLTPCLH MLPHSHFGLK DKELRFRKRY LDLILNPRVK DNFVIRSKII TFLRRYLDNL 240
  241 GFLEVETPIM NQIAGGATAK PFITHHNDLD MNLFLRVAPE LYHKMLVVGG IDRVYEVGRL 300
  301 FRNEGIDLTH NPEFTTCEFY MAYADYEDVI QLTEDLLSSM VMSIKGTYKI EYHPNGPNTE 360
  361 PVYEVDFTPP FKRVHMYDGL AEKLGATLPD PSTLHTEEAR EVFDKLCRDN NVDCSAPRTT 420
  421 ARLLDKLVGE YLESTFISPT FLIGHPQIMS PLAKWHRSIP GLTERFELFA VTREIANAYT 480
  481 ELNDPITQRQ RFEQQAKDKD AGDDEAQMID ETFCNALEYG LPPTGGWGMG IDRLSMILTD 540
  541 NNNIKEVLLF PAMRPEDGTE KKTDFDAPTT LA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..572] PSI-BLAST 142.0 Lysyl-tRNA synthetase (LysRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lysine-tRNA ligase activity
    		•  11.0047124677093 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  5.29805946490109 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  3.80084837437429 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  3.4145644216516 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.90150581291897 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.61548498770105 bayes_pls_golite062009
  • structural molecule activity
    		•  2.54582212334303 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  2.52223115725965 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67362693618722 bayes_pls_golite062009
  • binding
    		•  1.54403712698597 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48056625237411 bayes_pls_golite062009
  • DNA binding
    		•  1.44496421928708 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • transcription factor activity
    		•  0.825973629967327 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.77755643935497 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.702449673647117 bayes_pls_golite062009
  • nuclease activity
    		•  0.29926900436997 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle