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Protein Overview: CE02935

General Information:
Name(s) found: CE02935 [WormBase]
Description(s) found:
Found 16 descriptions.
SHOW ALL
  • WBGene00007143 Thiamine pyrophosphate enzymes status:Partially_confirmed UniProt:Q17475 protein_id:CAA91372.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 634 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: menaquinone biosynthetic process [IEALink to PubMed article]
    branched chain family amino acid biosynthetic process [IEALink to PubMed article]
    glyoxylate catabolic process [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    thiamin pyrophosphate binding [IEALink to PubMed article]
    acetolactate synthase activity [IEALink to PubMed article]
    2-oxoglutarate decarboxylase activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    FAD binding [IEALink to PubMed article]
    tartronate-semialdehyde synthase activity [IEALink to PubMed article]
    transferase activity [IEALink to PubMed article]
    carboxy-lyase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFLQKMFQS FCRVFGGRSV SLLVRRSQFS FAPQRGLISV IDKQQCRQIT DYSAKDSRIN  60
   61 SRKLRNHDGS NMDGASITAA ALKSQGVEYM FGVVGFPVIE VGMAAQAHGI KYIGCRNEQA 120
  121 AAYAAQAMGY LTGKPVALLV VSGPGILHAI GGLANATVNC WPVVCIGGTA DVDLENRGAF 180
  181 QEWSQQESVR NSCKHVSRPT SLHTIPAHIE KAVRCAMYGR PGAVYVDLPG NLVLTSTEEE 240
  241 ISFPPQVPLP APVSIPPIAE IEKAIDTLKS AKKPLVIVGK GAAWSERGAT QVQQFLTKSK 300
  301 LPWLATPGGK GVASDLHPRF IGQARSLALR EADTVFLIGA RFNWILHFGL PPRFQKDVKV 360
  361 VQIDICPEEF HQNVKTEVPL LGDIGETLAE LTPRLGDWTY DESTEWFKKL RENAEKNRAA 420
  421 VEKFVDDHST PLNYYAAYQP IREFLANNDV IVINEGANTM DIGRTMMPSR LPKRRLDAGT 480
  481 FGTMGVGHGF SLAAALWARD HSPKTKVLVV QGDSAFGFSA MELETIARYN LPVVTVIINN 540
  541 SGIYRGLLPE DDKAIEGDRT LALPVLSLTA ECRYEEMCKA FGGAGTVVRT VPEIKAALEK 600
  601 AFQKTDGPTV INALISTDSE RKPQADHWLT RSKM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..634] PSI-BLAST 96.522879 CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE IN COMPLEX WITH THE COFACTOR DERIVATIVE THIAMIN-2-THIAZOLONE DIPHOSPHATE AND ADENOSINE DIPHOSPHATE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  12.903449876837 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  12.3239025230705 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  5.28857071459273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.21233670052586 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  5.08663245333808 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.15444163802756 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.98546381612935 bayes_pls_golite062009
  • thiamin pyrophosphate binding
    		•  1.87247313698582 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.82969293063325 bayes_pls_golite062009
  • deoxyhypusine synthase activity
    		•  1.46517585302326 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.0611726850452 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.00103393476979 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.99977365092061 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.78591260444574 bayes_pls_golite062009
  • transketolase activity
    		•  0.762352619346583 bayes_pls_golite062009
  • binding
    		•  0.551586872853971 bayes_pls_golite062009
  • hydrolase activity
    		•  0.536729211484905 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.51426028502998 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.492590326775569 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.459800433209317 bayes_pls_golite062009
  • transferase activity
    		•  0.413024577830522 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  0.38348854354211 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  0.38348854354211 bayes_pls_golite062009
  • deacetylase activity
    		•  0.382228826641711 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.273969473413919 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.0424046736878951 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.50

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle