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Protein Overview: CE01907

General Information:
Name(s) found: CE01907 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00017393 Neprilysin status:Partially_confirmed UniProt:Q09946 protein_id:AAA68297.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 658 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: neprilysin activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKDQSSMLF FKDPENKNKN HVSHVEIGVP DPIEELQKLQ NRPEPCTVLA VITTLVILVL  60
   61 LIFALGALGL HDISAFKWEP KPQKALRIML DLPCQTKECV KYSAELLELM DSSVNPCENF 120
  121 HHHEKPDHRK AVNVVRRMLS KCAMGKTEEI HQVGRLSSII LPGLPFPLLN NSWTKPSDPI 180
  181 STSNSSTTYS YPFLTKILAH IILHNPDDAG FVGIKPSSDS EFSLFVVKPF SPVLTNFKFR 240
  241 NMYDILKRNA PESSTNGMID LEFDRQRQLN DVIKLQTKLE KIEFKADPEV VNLTEIQRQM 300
  301 PIIDWKRLID SWIPNGYAHL KEKVYGFNTS YYEEINAIIS STPSETIYNF LFLRFSFKFL 360
  361 RTEVASDLED TCLHQLSTTI PGKIVLYGSE EPEALNLLNG MLHTIKDQLK RSLATLKWMD 420
  421 SRGIEEAQKK FNKTKTVFGF TGEDLIDELV GKITPESNYI STLQNVLLWQ TRNMFKSVAE 480
  481 NNVTVFLNSE VFYSVEKNEI TISRALLHYP FMSANLPNYT NFATIASKIL PQMIHIFDER 540
  541 GRFYDSDGNH RNWWNTETER YFQIIVQCFD GMMQNVFGVS VSIGWNAYDS TKEPYATLPG 600
  601 IQQSSDEALF FYSMVKTMCT SDPDNVNEAL ASVPQFNSAF KCNNGTKMNP PTKCKLAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] deduced N/A No confident structure predictions are available.
    2 View Details [88..658] PSI-BLAST 142.0 Neutral endopeptidase (neprilysin)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.28121680160474 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.08393764313441 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.43815730024908 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.31358550762457 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.97707057855866 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  1.67079277233897 bayes_pls_golite062009
  • binding
    		•  1.35913617532168 bayes_pls_golite062009
  • hydrolase activity
    		•  1.04791095565584 bayes_pls_golite062009
  • receptor binding
    		•  1.03740562606541 bayes_pls_golite062009
  • bradykinin receptor binding
    		•  0.901852083543819 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.63315176426931 bayes_pls_golite062009
  • integrin binding
    		•  0.57684135424992 bayes_pls_golite062009
  • protein binding
    		•  0.430901196209551 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.21514043665594 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle