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Protein Overview: itt1

General Information:
Name(s) found: itt1 / SPAC1002.14 [Sanger Pombe]
Description(s) found:
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  • gi|74698421|sp|Q9US46.1|ITT1_SCHPO RecName: Full=E3 ubiquitin-protein ligase itt1; AltName: Full=RING finger protein itt1 [NCBI NR]
  • gi|6689271|emb|CAB65614.1| ubiquitin-protein ligase E3 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114414|ref|NP_593502.1| ubiquitin-protein ligase E3 (predicted) [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • ubiquitin-protein ligase E3 [Sanger Pombe]
  • E3 ubiquitin-protein ligase itt1 OS=Schizosaccharomyces pombe GN=itt1 PE=2 SV=1 [Swiss-Prot]
  • ZINC FINGER PROTEIN; ZF-C3HC4 TYPE (RING FINGER); SIMILAR TO S. CEREVISIAE YML068W: Q9US46; [pompepVF.fasta]
  • CONSERVED HYPOTHETICAL C3HC4 TYPE ZINC FINGER PROTEIN; SIMILAR TO S. CEREVISIAE YML068W: Q9US46; [pompepV13]
  • Conserved hypothetical C3HC4 type zinc finger protein, similar to yeast YML068W [pompep4896]
  • |itt1||zinc finger protein [pompepnew.fasta]
  • Zinc finger protein; zf-C3HC4 type (RING finger); ubiquitin-protein ligase (E3) (Predicted); IBR domains; RWD domain; similar to S. cerevisiae YML068W; involved in translation termination (Inhibition) (Predicted) (PMID 11570975) [4896.FASTAC]
  • |itt1||zinc finger protein|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • zinc finger protein; zf-C3HC4 type (RING finger); ubiquitin-protein ligase (E3) (predicted); IBR domains; RWD domain; similar to S. cerevisiae YML068W; involved in translation termination (inhibition) (predicted) (PMID 11570975) [Schizosaccharomyces pombe [nrdb_11152004_Chlamydomonas]
  • (Q9US46) Conserved hypothetical C3HC4 type zinc finger protein, similar to yeast YML068W [pompep4896_normal_reversed]
  • |itt1||ubiquitin-protein ligase E3 |Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPAC1002.14 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC1002.14 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • E3 ubiquitin-protein ligase itt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=itt1 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 435 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of translational termination [ISSLink to PubMed article]
    protein ubiquitination [ISSLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [ISSLink to PubMed article]
    zinc ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEVEVESDN KHLVADELIA LQSIYPEIHL DGNNYGRLNI PVNTESDYFL SFKSPDESTL  60
   61 TDTIVVRHFP DLVMEFFLPE AYPFNSPPTF FLKSSWLPLK QKRVLTSSLI KLWNEIHDCV 120
  121 LFDAIEHVRS IATIAFHLPT EMVFPGGFDD LKKEILAFDK NAKLLEFQIR KFQCNVCFDE 180
  181 FNGTDCFQLT RCGHVSCQSC LRDYYTMCIQ EGMFSQIKCI DLDCGKDAPV LTLKELESIV 240
  241 GVQLTNRYKE LEEKRRYEND SNIIFCPRSF CQGPSKRDPG QKLAICQKCD FAFCSFCQAT 300
  301 WHGDLSPCKL EGDSKKLVEM YLNYQENEPE KALELEKRYG KRIIDRLVEQ VKNDEEAEKW 360
  361 VLLNGQRCPT CDRVVERIDG CCHMNCLCGT HFCFLCGAYL MEQNPYKHFN DPVSSCYGML 420
  421 FASAAEKQRF SENWT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 17.69897 No description for 2ebmA was found.
    2 View Details [159..239] PSI-BLAST 6.045757 Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4
    3 View Details [240..325] PSI-BLAST 4.39794 No description for 2jmoA was found.
    4 View Details [326..435] MSA 6.614995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.65442784325159 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.55686022186257 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.59153177011595 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • transcription activator activity
    		•  1.45530270292081 bayes_pls_golite062009
  • ligase activity
    		•  1.36029325773279 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.926364718530146 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.90321253993065 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.350170315296021 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.24963159801049 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle