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View Structure Prediction Details

Protein: itt1
Organism: Schizosaccharomyces pombe
Length: 435 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for itt1.

Description E-value Query
Range
Subject
Range
gi|46125333, gi|... - gi|46125333|ref|XP_387220.1| hypothetical protein FG07044.1 [Gibberella zeae PH-1], gi|42553760|gb|E...
240.0 [0..3] [433..122]
gi|114602433 - gi|114602433|ref|XP_001152699.1| PREDICTED: ring finger protein 14 isoform 8 [Pan troglodytes]
232.0 [0..6] [421..53]
gi|148225442, gi... - gi|54038664|gb|AAH84251.1| LOC495084 protein [Xenopus laevis], gi|148225442|ref|NP_001088253.1| hypo...
230.0 [0..6] [421..1]
gi|57042714, gi|... - gi|73949443|ref|XP_849246.1| PREDICTED: similar to RING finger protein 14 (Androgen receptor-associa...
229.0 [0..6] [423..1]
RNF14_MOUSE - E3 ubiquitin-protein ligase RNF14 OS=Mus musculus GN=Rnf14 PE=1 SV=2
228.0 [0..6] [423..1]
gi|48145521 - gi|48145521|emb|CAG32983.1| RNF14 [Homo sapiens]
227.0 [0..6] [421..1]
gi|109079101, gi... - gi|109079103|ref|XP_001095249.1| PREDICTED: ring finger protein 14 isoform 4 [Macaca mulatta], gi|10...
227.0 [0..6] [421..1]
gi|197097758 - gi|197097758|ref|NP_001125890.1| ring finger protein 14 [Pongo abelii]
gi|55729565 - gi|55729565|emb|CAH91513.1| hypothetical protein [Pongo abelii]
227.0 [0..6] [421..1]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEVEVESDN KHLVADELIA LQSIYPEIHL DGNNYGRLNI PVNTESDYFL SFKSPDESTL  60
   61 TDTIVVRHFP DLVMEFFLPE AYPFNSPPTF FLKSSWLPLK QKRVLTSSLI KLWNEIHDCV 120
  121 LFDAIEHVRS IATIAFHLPT EMVFPGGFDD LKKEILAF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 2ebmA
Description: No description for 2ebmA was found.

Predicted Domain #2
Region A:
Residues: [159-239]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKNAKLLEFQ IRKFQCNVCF DEFNGTDCFQ LTRCGHVSCQ SCLRDYYTMC IQEGMFSQIK  60
   61 CIDLDCGKDA PVLTLKELES I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 1wimA
Description: Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.65442784325159 bayes_pls_golite062009
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription activator activity 1.45530270292081 bayes_pls_golite062009
ligase activity 1.36029325773279 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
sequence-specific DNA binding 0.926364718530146 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.24963159801049 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [240-325]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVQLTNRYK ELEEKRRYEN DSNIIFCPRS FCQGPSKRDP GQKLAICQKC DFAFCSFCQA  60
   61 TWHGDLSPCK LEGDSKKLVE MYLNYQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 2jmoA
Description: No description for 2jmoA was found.

Predicted Domain #4
Region A:
Residues: [326-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENEPEKALEL EKRYGKRIID RLVEQVKNDE EAEKWVLLNG QRCPTCDRVV ERIDGCCHMN  60
   61 CLCGTHFCFL CGAYLMEQNP YKHFNDPVSS CYGMLFASAA EKQRFSENWT 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle