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View Structure Prediction Details

Protein: itt1
Organism: Schizosaccharomyces pombe
Length: 435 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for itt1.

Description E-value Query
Range		 Subject
Range
gi|46125333, gi|... - gi|46125333|ref|XP_387220.1| hypothetical protein FG07044.1 [Gibberella zeae PH-1], gi|42553760|gb|E...
 240.0 [0..3] [433..122]
gi|114602433 - gi|114602433|ref|XP_001152699.1| PREDICTED: ring finger protein 14 isoform 8 [Pan troglodytes]
 232.0 [0..6] [421..53]
gi|148225442, gi... - gi|54038664|gb|AAH84251.1| LOC495084 protein [Xenopus laevis], gi|148225442|ref|NP_001088253.1| hypo...
 230.0 [0..6] [421..1]
gi|57042714, gi|... - gi|73949443|ref|XP_849246.1| PREDICTED: similar to RING finger protein 14 (Androgen receptor-associa...
 229.0 [0..6] [423..1]
RNF14_MOUSE - E3 ubiquitin-protein ligase RNF14 OS=Mus musculus GN=Rnf14 PE=1 SV=2
 228.0 [0..6] [423..1]
gi|48145521 - gi|48145521|emb|CAG32983.1| RNF14 [Homo sapiens]
 227.0 [0..6] [421..1]
gi|109079101, gi... - gi|109079103|ref|XP_001095249.1| PREDICTED: ring finger protein 14 isoform 4 [Macaca mulatta], gi|10...
 227.0 [0..6] [421..1]
gi|197097758 - gi|197097758|ref|NP_001125890.1| ring finger protein 14 [Pongo abelii]
gi|55729565 - gi|55729565|emb|CAH91513.1| hypothetical protein [Pongo abelii]
 227.0 [0..6] [421..1]

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Predicted Domain #1
Region A:
Residues: [1-158] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEVEVESDN KHLVADELIA LQSIYPEIHL DGNNYGRLNI PVNTESDYFL SFKSPDESTL  60
   61 TDTIVVRHFP DLVMEFFLPE AYPFNSPPTF FLKSSWLPLK QKRVLTSSLI KLWNEIHDCV 120
  121 LFDAIEHVRS IATIAFHLPT EMVFPGGFDD LKKEILAF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 2ebmA
Description: No description for 2ebmA was found.

Predicted Domain #2
Region A:
Residues: [159-239] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKNAKLLEFQ IRKFQCNVCF DEFNGTDCFQ LTRCGHVSCQ SCLRDYYTMC IQEGMFSQIK  60
   61 CIDLDCGKDA PVLTLKELES I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 1wimA
Description: Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.65442784325159 bayes_pls_golite062009
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription activator activity 1.45530270292081 bayes_pls_golite062009
ligase activity 1.36029325773279 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
sequence-specific DNA binding 0.926364718530146 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.24963159801049 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [240-325] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGVQLTNRYK ELEEKRRYEN DSNIIFCPRS FCQGPSKRDP GQKLAICQKC DFAFCSFCQA  60
   61 TWHGDLSPCK LEGDSKKLVE MYLNYQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 2jmoA
Description: No description for 2jmoA was found.

Predicted Domain #4
Region A:
Residues: [326-435] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENEPEKALEL EKRYGKRIID RLVEQVKNDE EAEKWVLLNG QRCPTCDRVV ERIDGCCHMN  60
   61 CLCGTHFCFL CGAYLMEQNP YKHFNDPVSS CYGMLFASAA EKQRFSENWT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.495 0.479 regulation of translational termination a.3.1 Cytochrome c
View Download 0.287 0.041 regulation of translational termination a.74.1 Cyclin-like
View Download 0.303 0.031 regulation of translational termination d.129.1 TATA-box binding protein-like
View Download 0.247 0.021 regulation of translational termination a.64.1 Saposin
View Download 0.211 0.003 regulation of translational termination a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle