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Protein Overview: pku70

General Information:
Name(s) found: pku70 / SPCC126.02c [Sanger Pombe]
Description(s) found:
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  • pir||T40906 probable ATP-dependent DNA helicase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74582874|sp|O94395.1|KU70_SCHPO RecName: Full=ATP-dependent DNA helicase II subunit 1; AltName: Full=ATP-dependent DNA helicase II subunit Ku70 [NCBI NR]
  • gi|4008550|emb|CAA22471.1| Ku domain protein Pku70 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075945|ref|NP_588445.1| Ku domain protein Pku70 [Schizosaccharomyces pombe] [NCBI NR]
  • Ku domain protein Pku70 [Sanger Pombe]
  • ATP-dependent DNA helicase II subunit 1 OS=Schizosaccharomyces pombe GN=pku70 PE=1 SV=1 [Swiss-Prot]
  • INVOLVED IN DNA DOUBLE-STRAND BREAK REPAIR AND TELOMERE MAINTENANCE: O94395; [pompepVF.fasta]
  • PROTEIN INVOLVED IN DNA DOUBLE-STRAND BREAK REPAIR AND TELOMERE MAINTENANCE: O94395; [pompepV13]
  • Putative ATP-dependent DNA helicase [pompep4896]
  • |pku70||involved in double strand break (DSB) repair [pompepnew.fasta]
  • SPCC126.02c protein (Pku70 protein) [4896.FASTAC]
  • |pku70||DNA helicase|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • putative ATP-dependent DNA helicase [Schizosaccharomyces pombe]gi|4008550|emb|CAA22471.1| SPCC126.02c [Schizosaccharomyces pombe]gi|7492415|pir||T40906 probable ATP-dependent DNA helicase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |pku70||Ku domain protein|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • (O94395) Putative ATP-dependent DNA helicase [pompep4896_normal_reversed]
  • |pku70||Ku domain protein Pku70|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPCC126.02c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPCC126.02c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • ATP-dependent DNA helicase II subunit 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pku70 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 607 amino acids

    Gene Ontology:
    Cellular Component: chromosome, telomeric region [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    DNA-dependent protein kinase-DNA ligase 4 complex [IEA]
    Biological Process: S phase of mitotic cell cycle [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    telomeric DNA binding [IDALink to PubMed article]
    protein heterodimerization activity [IPILink to PubMed article]
    ATP-dependent DNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENDEQIDET ENFAIGKYAI LFVIEVSPSM LDPVDEFTPS SLQMALICAY QLAAQRVITN  60
   61 PSDIMGVLLY GTESSTGRFA NQMMLLDIDP PDAERIKSLQ SFEKDFQFSK EKFKPCSCQV 120
  121 SLSSVLYHCS VIFTTKAENF EKRLFLITDN DHPAWDATER DIILQRAKDL RDLDIQVHPV 180
  181 FLDPPTHSFR INIFYSDFLY IVYGRQDVSN LVNRGQAQLQ HMLNMITALQ KPKRAHFHLK 240
  241 MDLGNDVRIG VEAFILLKRL ESAKTNWVYA KGERFAVAVP QSKQVSFATK KELKKDEIRR 300
  301 SYSYGGSSVV FGSDELNKVR SFEPPTLRII GFRDFSTLKP WHCLKPAVFL RPKDDEIIGS 360
  361 GAVFSAIHKK LLASNKIGIA WFVSRPNANP CFVAMLATPG SIHIRDDFEL PLGIFLVQLP 420
  421 TADDIRSLPP INPNPISMPS NLIETMQRIL RGMELRSYQP GKYNNPSLQW HYKVLQALAL 480
  481 DEEIPTDFVD NTLPKYKAIQ KRVGEYMGDV NNIVAEYRND ISDKNGIKEE EEDQGPIVKK 540
  541 ARIEKSGKPI FAEDDRLKQL YIEGVLDKEI KALKVSQLKD ILRDRGLRVS GKKADLLDNL 600
  601 TNYVKKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..607] PSI-BLAST 161.0 DNA binding C-terminal domain of ku70; Ku70 subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.64621483095491 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05720838352689 bayes_pls_golite062009
  • promoter binding
    		•  3.01492777192913 bayes_pls_golite062009
  • transcription activator activity
    		•  2.87080577911324 bayes_pls_golite062009
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • protein binding
    		•  2.58357303743968 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.08531850924748 bayes_pls_golite062009
  • DNA binding
    		•  1.91667917801679 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37299910766941 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • protein complex binding
    		•  0.94234534987624 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.914051610867509 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.73404855126602 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.720743494912414 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.64812784969409 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • structural molecule activity
    		•  0.375125487765613 bayes_pls_golite062009
  • receptor binding
    		•  0.234020194580985 bayes_pls_golite062009
  • transcription factor binding
    		•  0.184852480703492 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
  • identical protein binding
    		•  0.125363466534611 bayes_pls_golite062009
  • collagen binding
    		•  0.113837148027681 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0660601071978013 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle