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Protein Overview: nep2

General Information:
Name(s) found: nep2 / SPBC32H8.02c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • nedd8 protease Nep2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 415 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: [NOT]protein sumoylation [IMPLink to PubMed article]
    [NOT]protein desumoylation [IMPLink to PubMed article]
    proteolysis [ICLink to PubMed article]
    protein deneddylation [IDALink to PubMed article]
    Molecular Function: NEDD8-specific protease activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSNSIFTKE IDSEAVKKSS NLRPPSTGSS NSNGSDTASP KKKKKGFFRS LFGSSSSGSK  60
   61 SCGSPFTRIW LEYFEVSLRK NDVDHFRPGY WILDTNIDFF YEIMLRQVLL KRPKEESQQI 120
  121 YLLRPAMVFF LAQAPNPLEI ESALPPAMFD ASFIFLPIND TNECGIESGS HWSLLVVSVE 180
  181 KGLGWYYDSM SNGNTNDCNL AIKNLGILLK KEFRVRHMKT PQQINDCDCG LHVCENTRIL 240
  241 MYRLLQKPYV PKVDMNLDHS VVDSVRLRKA LMEVITSLLA AYGSKVPKPS ETHTDPEKDK 300
  301 KIFSKICKTE ELLELPTLSA VTSDSAQPHS LPASMPSSQP QSRSESLPLT HPNSEPNPKL 360
  361 DSQPNSSPVR RPSLIKVKTA STSVLPTSIL QRPPSIVPRP ETAAIQHTQQ SIEIH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..262] PSI-BLAST 39.09691 Structure of human Senp2 in complex with SUMO-1
    2 View Details [263..415] FFAS03 1.34 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.52987342617304 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  3.91170685383331 bayes_pls_golite062009
  • peptidase activity
    		•  3.28868056127375 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.01472402774099 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • hydrolase activity
    		•  2.29464693834116 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.26699762664334 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.16768752586311 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.3276268995308 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  1.01104209091599 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439226369799415 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • DNA binding
    		•  0.168761518285256 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.144331158319621 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle