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Protein Overview: raf1

General Information:
Name(s) found: raf1 / SPCC613.12c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • Rik1-associated factor Raf1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 638 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [TASLink to PubMed article]
    nucleus [IDALink to PubMed articleLink to PubMed article]
    CLRC ubiquitin ligase complex [IDALink to PubMed article]
    nuclear centromeric heterochromatin [ICLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: meiotic telomere clustering [IMPLink to PubMed article]
    positive regulation of histone H3-K9 methylation [IMPLink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    negative regulation of histone H3-K4 methylation [IMPLink to PubMed article]
    regulation of mating type switching [IMPLink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    meiotic sister chromatid cohesion, centromeric [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed article]
    chromatin silencing by small RNA [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNSSPRVKR RTDTQYLHSV SSKLPKVDFD TNNEEFFEEE FEIYDPFYRA ELPCPKPSLS  60
   61 ISKHSIAKVP SNVNKRLELQ LLLTSGTFLP NSRPYLSERV RKHTHLLSNS ITGDDKPSLI 120
  121 HVDFTPEECF ILQEAKLKFG PVNSVQFNDA YSTHISPKLP GRAYEDCQKF EIDNPSLSPV 180
  181 DKHGAIILRT YKKNKKLLPD YLKSFYNAGS SYFQREQVHQ LMDGESVFFL KPWKHFNETS 240
  241 GDTVCVAYNP LCEKFALGST AQDGAYNRLG NLWIGDFHSE TIQSLESHYK LNQVGEKEYS 300
  301 TISDLCFSKG NLFLYTGAFD NAVKVWDMEG NLCGIFNAPT DYIHKLALSD DDLLAVACKN 360
  361 GYGYLLSTDN STGEILTSAN LIYPEALEKG YSASLIEFSN FLGRSSDKVI IGYDSFHTSN 420
  421 NRGCLALFDA STASFVQKFN TADEAFTSLY MHPSQVGFVA SSNTLSNGRV YYLDTRMYKV 480
  481 CLNFTTTQKD INHATISNSG ILVTSSGTDN QTFVWDSRKP DKPLSLLKHG KTKMIHFDGA 540
  541 NEEEVDAGIN MAQWQPKGNL FVTGGSDGIV KVWDLRLNNP FIQNFTEMNS AITYGGFSED 600
  601 ASKLTVCCVG GDVNMYSLGN DNGNKFGEFR IIENRLLT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..638] PSI-BLAST 32.221849 Actin interacting protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  4.19952434162673 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  4.18507211043146 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  3.22476183756271 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.85632145559025 bayes_pls_golite062009
  • ligase activity
    		•  1.82531515493699 bayes_pls_golite062009
  • dynein binding
    		•  1.74989209255308 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.56129742850468 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.35170368882651 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.15313682561559 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • transporter activity
    		•  0.284701931503833 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.00335766408304172 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle