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Protein Overview: brc1

General Information:
Name(s) found: brc1 / SPBC582.05c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • BRCT domain protein Brc1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 878 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: DNA repair [ISSLink to PubMed article]
    chromosome organization [IGILink to PubMed article]
    regulation of DNA recombination [NASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKIKLLNVK TPNHYTIIFK VVAYYSALQP NQNELRKKEL FIKNDGKALS FPYDWKLATH  60
   61 VICDDFSSPN VQEGSKRSLR LAKTNWIRDC VDKNTLLNYS FYSCNPYLLF KGICASSCQI 120
  121 DSYQSSLIDD ALETFGGRFS KGLMKSMTHL FTYSGMGAKC KKVLDKPSLS IKLIHPQWLL 180
  181 DCLQFGQLID QDPYLFPNPS YKKNDSSISK AEPTSLFRNV LHGKRIYFSN DLNLPTNFRH 240
  241 SLQKFSVGIG AKIAESINDC DIFIGLKRDT IEFNLASNKN TTIGTISWLL NLFVLGSWKS 300
  301 PLLNALHYPF PSVGFLKDQM VAVTNYTDAA RIYLEKLLLA CGATYTKDLK PTNTLLIAAS 360
  361 SYGQKYGAAK VWNIPTVHHS WLYSSFKNLS SQAFTDFPVP LDDSYMDFIF PCPLNVEKGS 420
  421 FEDTLKSSLT KGNSEVLLDD LSDPSVSSIK GNKTNEELEK EFKSTSDNFG KHIILTSSFS 480
  481 NQSADKGSSL AAEDDRNDEG STITGVNREL QDEGRLEIDA KSSKTNTPPS PLLVGTPSKE 540
  541 SLKEASSDDE LPVLATKLVD NVIKEKSPLS LTPKVVVPSH KETYTDEKKL IDELDRVNPL 600
  601 NSSQLLRSKR KSAATALSML QNVIMPDVLA FEREKKRRQT HRSVSSGEVS RESSESRNTN 660
  661 AKASKRVYIT FTGYDKKPSI DNLKKLDMSI TSNPSKCTHL IAPRILRTSK FLCSIPYGPC 720
  721 VVTMDWINSC LKTHEIVDEE PYLLNDPEKE LELGCTLESA LKRARAQGPS LLEDYVVYLT 780
  781 SKTVAPENVP AVISIVKSNG GVCSTLNVYN KRLARHLEDG NVVLITCNED SHIWTNFLDN 840
  841 ASQNKTIFLQ NYDWLIKTVL RQEIDVNDRI ADEFARAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 21.39794 The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product
    2 View Details [87..387] PSI-BLAST 35.39794 No description for 2owoA was found.
    3 View Details [388..458] deduced N/A No confident structure predictions are available.
    4 View Details [459..650] deduced N/A No confident structure predictions are available.
    5 View Details [651..878] PSI-BLAST 41.0 Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • damaged DNA binding
    		•  2.78264840479873 bayes_pls_golite062009
  • DNA binding
    		•  2.7698198756738 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.61633684028078 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.5081824552293 bayes_pls_golite062009
  • binding
    		•  2.39904249850929 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.41538783957147 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.26128385496855 bayes_pls_golite062009
  • protein binding
    		•  1.25126059595954 bayes_pls_golite062009
  • transcription activator activity
    		•  0.855915697559548 bayes_pls_golite062009
  • transcription factor binding
    		•  0.79968459369401 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.436014478237905 bayes_pls_golite062009
  • catalytic activity
    		•  0.17721113579921 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.163902958036495 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.00883892441550604 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle