YRC Public Data Repository - Protein Structure Prediction

Protein:	brc1
Organism:	Schizosaccharomyces pombe
Length:	878 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for brc1.

Description	E-value	Query Range	Subject Range
gi\|85085755 - gi\|85085755\|ref\|XP_957563.1\| hypothetical protein ( (AL356172) conserved hypothetical protein [Neuro... gi\|28918656, gi\|... - gi\|32405260\|ref\|XP_323243.1\| hypothetical protein ( (AL356172) conserved hypothetical protein [Neuro...	354.0	[0..15]	[869..7]
gi\|46128045, gi\|... - gi\|46128045\|ref\|XP_388576.1\| hypothetical protein FG08400.1 [Gibberella zeae PH-1], gi\|42548309\|gb\|E...	344.0	[0..19]	[874..5]
gi\|39973643, gi\|... - gi\|39973643\|ref\|XP_368212.1\| hypothetical protein MGG_01032 [Magnaporthe grisea 70-15], gb\|EAA49374....	343.0	[0..11]	[868..1]
gi\|67526405, gi\|... - gi\|67526405\|ref\|XP_661264.1\| hypothetical protein AN3660.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	338.0	[0..13]	[874..6]
gi\|116202497, gi... - gi\|88177651\|gb\|EAQ85119.1\| hypothetical protein CHGG_09133 [Chaetomium globosum CBS 148.51], gi\|1162...	317.0	[0..16]	[868..8]
gi\|70993506, gi\|... - gi\|70993506\|ref\|XP_751600.1\| DNA repair protein Rtt107 [Aspergillus fumigatus Af293], gi\|66849234\|gb... gi\|159125473 - gi\|159125473\|gb\|EDP50590.1\| BRCT domain protein [Aspergillus fumigatus A1163]	312.0	[0..17]	[868..9]
gi\|83764751 - gi\|83764751\|dbj\|BAE54895.1\| unnamed protein product [Aspergillus oryzae] gi\|169764851 - gi\|169764851\|ref\|XP_001816897.1\| hypothetical protein [Aspergillus oryzae RIB40]	303.0	[0..13]	[873..5]
gi\|45187728, gi\|... - gi\|45187728\|ref\|NP_983951.1\| ADL145Cp [Ashbya gossypii ATCC 10895], gi\|44982489\|gb\|AAS51775.1\| ADL14... gi\|44982489 - gi\|44982489\|gb\|AAS51775.1\| ADL145Cp [Ashbya gossypii ATCC 10895]	290.0	[0..14]	[873..3]
orf19.1445, orf1... - ESC4 CGDID:CAL0004594 Assembly 19, Contig19-10119 (11560, 8849) CDS, reverse complemented, translate... gi\|46444326, gi\|... - gi\|68466882\|ref\|XP_722356.1\| hypothetical protein CaO19.9020 [Candida albicans SC5314], gi\|68466599\|...	273.0	[0..18]	[871..1]
gi\|37359872 - gi\|37359872\|dbj\|BAC97914.1\| mKIAA0259 protein [Mus musculus]	268.0	[0..7]	[860..599]

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Predicted Domain #1

Region A:
Residues: [1-86]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKIKLLNVK TPNHYTIIFK VVAYYSALQP NQNELRKKEL FIKNDGKALS FPYDWKLATH  60
   61 VICDDFSSPN VQEGSKRSLR LAKTNW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	21.39794
Match:	1wf6A
Description:	The third BRCA1 C-terminus (BRCT) domain of Similar to S.pombe rad4+/cut5+ product
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
damaged DNA binding	2.78264840479873	bayes_pls_golite062009
DNA binding	2.7698198756738	bayes_pls_golite062009
nucleic acid binding	2.61633684028078	bayes_pls_golite062009
transcription regulator activity	2.5081824552293	bayes_pls_golite062009
binding	2.39904249850929	bayes_pls_golite062009
sequence-specific DNA binding	1.41538783957147	bayes_pls_golite062009
telomeric DNA binding	1.26128385496855	bayes_pls_golite062009
protein binding	1.25126059595954	bayes_pls_golite062009
transcription activator activity	0.855915697559548	bayes_pls_golite062009
transcription factor binding	0.79968459369401	bayes_pls_golite062009
structure-specific DNA binding	0.436014478237905	bayes_pls_golite062009
catalytic activity	0.17721113579921	bayes_pls_golite062009
double-stranded DNA binding	0.163902958036495	bayes_pls_golite062009
transcription repressor activity	0.00883892441550604	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [87-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRDCVDKNTL LNYSFYSCNP YLLFKGICAS SCQIDSYQSS LIDDALETFG GRFSKGLMKS  60
   61 MTHLFTYSGM GAKCKKVLDK PSLSIKLIHP QWLLDCLQFG QLIDQDPYLF PNPSYKKNDS 120
  121 SISKAEPTSL FRNVLHGKRI YFSNDLNLPT NFRHSLQKFS VGIGAKIAES INDCDIFIGL 180
  181 KRDTIEFNLA SNKNTTIGTI SWLLNLFVLG SWKSPLLNAL HYPFPSVGFL KDQMVAVTNY 240
  241 TDAARIYLEK LLLACGATYT KDLKPTNTLL IAASSYGQKY GAAKVWNIPT VHHSWLYSSF 300
  301 K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.39794
Match:	2owoA
Description:	No description for 2owoA was found.

Predicted Domain #3

Region A:
Residues: [388-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLSSQAFTDF PVPLDDSYMD FIFPCPLNVE KGSFEDTLKS SLTKGNSEVL LDDLSDPSVS  60
   61 SIKGNKTNEE L

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [459-650]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKEFKSTSDN FGKHIILTSS FSNQSADKGS SLAAEDDRND EGSTITGVNR ELQDEGRLEI  60
   61 DAKSSKTNTP PSPLLVGTPS KESLKEASSD DELPVLATKL VDNVIKEKSP LSLTPKVVVP 120
  121 SHKETYTDEK KLIDELDRVN PLNSSQLLRS KRKSAATALS MLQNVIMPDV LAFEREKKRR 180
  181 QTHRSVSSGE VS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [651-878]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RESSESRNTN AKASKRVYIT FTGYDKKPSI DNLKKLDMSI TSNPSKCTHL IAPRILRTSK  60
   61 FLCSIPYGPC VVTMDWINSC LKTHEIVDEE PYLLNDPEKE LELGCTLESA LKRARAQGPS 120
  121 LLEDYVVYLT SKTVAPENVP AVISIVKSNG GVCSTLNVYN KRLARHLEDG NVVLITCNED 180
  181 SHIWTNFLDN ASQNKTIFLQ NYDWLIKTVL RQEIDVNDRI ADEFARAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.0
Match:	2azmA
Description:	Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: