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Protein Overview: SPBC106.12c

General Information:
Name(s) found: SPBC106.12c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • THO complex subunit [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 274 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    THO complex [ISSLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [ISSLink to PubMed article]
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [ISSLink to PubMed article]
    regulation of RNA elongation from RNA polymerase II promoter [ISSLink to PubMed article]
    mRNA processing [ISSLink to PubMed article]
    Molecular Function: RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEKSLDEI INERTNGFDH KHSRRRGSQN RISKKSRLTY KFKRASKEHN SSPDDGPWQH  60
   61 DLDQEQDAHP RTTHLQKRQH SENRFGVRVE NLHYQVLEKD VLSLFENFHP IRVIMNYDRA 120
  121 GRSEGSCDVY FETSQDAEDA QKTLQSTNLK GSEIQISKKS PPSLFDRISD MPHSARKPSR 180
  181 SSRSNRGFNR SSKKDDRSFR SSSKKSSNNS ISHEDLDKEL DEYAMSFHAA STVSSHSSQD 240
  241 FTPSIANAHE KNEPVAPSKD SNLTEEMDLQ MEAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] PSI-BLAST 33.09691 Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)
    2 View Details [174..274] PSI-BLAST 13.0 Polypyrimidine tract-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.15097136329571 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.92126426323641 bayes_pls_golite062009
  • mRNA binding
    		•  4.05281507540116 bayes_pls_golite062009
  • binding
    		•  3.64400841800969 bayes_pls_golite062009
    		• 3.4479220904723 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.98418556946403 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.36691748240059 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription factor activity
    		•  1.07843408116687 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.961194066054671 bayes_pls_golite062009
  • snRNA binding
    		•  0.73428616955527 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.632534695085793 bayes_pls_golite062009
  • transporter activity
    		•  0.628672636801176 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • hydrolase activity
    		•  0.520121701073354 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.505106991526286 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.440554367505651 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.383589644462932 bayes_pls_golite062009
  • structural molecule activity
    		•  0.187199936070111 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.182749906784328 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.096231856558874 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.059732432409948 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0510390778764699 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0484248928275733 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle