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Protein Overview: slx8

General Information:
Name(s) found: slx8 / SPBC3D6.11c [Sanger Pombe]
Description(s) found:
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  • pir||T40371 probable zinc finger protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|2117307|emb|CAB09120.1| SUMO-targeted ubiquitin-protein ligase E3 Slx8 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|20140564|sp|P87176.1|SLX8_SCHPO RecName: Full=E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8; AltName: Full=RING-dependent E3 ubiquitin-protein ligase slx8; AltName: Full=RING finger protein slx8; AltName: Full=Synthetic lethal of unknown fu [NCBI NR]
  • gi|19112315|ref|NP_595523.1| ubiquitin-protein ligase E3 Slx8 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • ubiquitin-protein ligase E3 Slx8 [Sanger Pombe]
  • Uncharacterized RING finger protein C3D6.11c - Schizosaccharomyces pombe (Fission yeast) [Swiss-Prot]
  • E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 OS=Schizosaccharomyces pombe GN=slx8 PE=1 SV=1 [Swiss-Prot]
  • ZINC FINGER PROTEIN; ZF-C3HC4 TYPE (RING FINGER); SIMILAR TO S. CEREVISIAE YER116C: P87176;Q9US65; [pompepVF.fasta]
  • PUTATIVE ZINC FINGER PROTEIN; SIMILAR TO YEAST YER116C: P87176;Q9US65; [pompepV13]
  • Hypothetical RING finger protein C3D6.11c in chromosome II [pompep4896]
  • |||zinc finger protein [pompepnew.fasta]
  • |slx8||zinc finger protein|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • putative zinc finger protein [Schizosaccharomyces pombe]gi|20140564|sp|P87176|YB1B_SCHPO Hypothetical RING finger protein C3D6.11c in chromosome IIgi|7493175|pir||T40371 probable zinc finger protein - fission yeast (Schizosaccharomyces pombe)gi|211730 [nrdb_11152004_Chlamydomonas]
  • (P87176) Hypothetical RING finger protein C3D6.11c in chromosome II [pompep4896_normal_reversed]
  • |slx8||SUMO-targeted ubiquitin-protein ligase E3 Slx8 |Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBC3D6.11c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC3D6.11c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=slx8 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 269 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    SUMO-targeted ubiquitin ligase complex [IPILink to PubMed article]
    Biological Process: DNA damage checkpoint [IMPLink to PubMed article]
    DNA recombination [IGILink to PubMed article]
    negative regulation of protein sumoylation [IMPLink to PubMed articleLink to PubMed article]
    protein ubiquitination [IDALink to PubMed articleLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed articleLink to PubMed article]
    zinc ion binding [ISSLink to PubMed article]
    protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPAHKRDTN VRNLSAPYNI PSQSARVAAG NAAINRRRSS PVENSPGNGF PVSEDATDYP  60
   61 SGTTSENESL PLNRAPRSLR EVASELAQEE TLPVETSDLN IDVESEVFDL EDINFQNDAD 120
  121 DINQRFTYNN HPASVENSLT NVNSIHAQPT TISDMIDLTD ETSYDPRKQK FEQGKNPSTT 180
  181 NAEIEKEEPS KKQVVPSSQR LADYKCVICL DSPENLSCTP CGHIFCNFCI LSALGTTAAT 240
  241 QKCPVCRRKV HPNKVICLEM MLGSQKKKS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] PSI-BLAST 8.522879 Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
    2 View Details [103..269] PSI-BLAST 5.39794 Crystal structure of the CHIP U-box E3 ubiquitin ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  10.2497392096259 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  10.0460587929138 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.99384576623969 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.6988425139962 bayes_pls_golite062009
  • ligase activity
    		•  3.92677358871643 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.93290256907934 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65245433674494 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  1.64302727579554 bayes_pls_golite062009
  • protein binding
    		•  1.5975811408548 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.40546445536977 bayes_pls_golite062009
  • DNA binding
    		•  1.36987440722489 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • transcription factor binding
    		•  0.87358980288412 bayes_pls_golite062009
  • transcription factor activity
    		•  0.679771179415046 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • SUMO polymer binding
    		•  0.492200528146501 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle