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Protein Overview: srs2

General Information:
Name(s) found: srs2 / SPAC4H3.05 [Sanger Pombe]
Description(s) found:
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  • pir||T38885 probable ATP-dependent DNA helicase (EC 3.6.1.-) - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19115253|ref|NP_594341.1| ATP-dependent DNA helicase, UvrD subfamily [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1723281|sp|Q10213.1|SRS2_SCHPO RecName: Full=ATP-dependent DNA helicase srs2 [NCBI NR]
  • gi|1184018|emb|CAA93344.1| ATP-dependent DNA helicase, UvrD subfamily [Schizosaccharomyces pombe] [NCBI NR]
  • ATP-dependent DNA helicase, UvrD subfamily [Sanger Pombe]
  • ATP-dependent DNA helicase srs2 OS=Schizosaccharomyces pombe GN=srs2 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE ATP-DEPENDENT DNA HELICASE REQUIRED FOR MAINTENANCE OF NORMAL LEVELS OF RESISTANCE TO DNA DAMAGE, AND FOR SUPPRESSION OF MITOTIC RECOMBINATION: Q10213; [pompepVF.fasta]
  • Probable ATP-dependent DNA helicase C4H3.05 (EC 3.6.1.-) [pompep4896]
  • |srs2||UVRD helicase [pompepnew.fasta]
  • ATP-dependent DNA helicase srs2 (EC 3.6.1.-) [4896.FASTAC]
  • |srs2||DNA helicase|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative UvrD/REP ATP-dependent DNA helicase (EC 3.6.1.-) [Schizosaccharomyces pombe]gi|1184018|emb|CAA93344.1| SPAC4H3.05 [Schizosaccharomyces pombe]gi|7492414|pir||T38885 probable ATP-dependent DNA helicase (EC 3.6.1.-) - fission yeast (Schizosaccharo [nrdb_11152004_Chlamydomonas]
  • |srs2||ATP-dependent DNA helicase, UvrD subfamily|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q10213) Probable ATP-dependent DNA helicase C4H3.05 (EC 3.6.1.-) [pompep4896_normal_reversed]
  • hypothetical protein SPAC4H3.05 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC4H3.05 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • ATP-dependent DNA helicase srs2 [nr-271106-contam.fasta]
  • ATP-dependent DNA helicase srs2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=srs2 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 887 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    spindle [IDALink to PubMed article]
    Biological Process: recombinational repair [IGILink to PubMed article][IMPLink to PubMed article]
    cellular response to UV [IMPLink to PubMed article]
    replication fork processing [TASLink to PubMed article]
    postreplication repair [IGILink to PubMed article]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    ATP-dependent DNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METKSSYLKF LNEEQRISVQ SPHKYTQILA GPGSGKTRVL TARVAYLLQK NHIAAEDLII  60
   61 ATFTNKAANE IKLRIEAILG NSEASKLISG TFHSIAYKYL VKYGKHIGLS SNWLIADRND 120
  121 TQAIMKRLLD SLKKAKNPIA SGIRGQELTP QNALNRITKL KSNGLLVKPG MDQLSLINGL 180
  181 EEPPKELQSH QSVELYRLYQ TSLWKNNLAD FDDLLLNFIL LLQKQPDCVR NIKHILIDEF 240
  241 QDTSKIQYFL VKLLALQNSD ITIVGDPDQS IYGFRSAEIR NLNQMSEDFE GTQVLHLERN 300
  301 YRSAKPILEL ALSIISQDKS RPKKGLKSNH ISSLKPHYRL FETNNKESYW IAREIKRIVG 360
  361 SCPELIFYND IAILVRSSSL TRSLEHALSE LGVPYRMVGV NKFFDREEIR DLIAYLRVLA 420
  421 NKDSTSLIRV INVPPRNIGK TKIDRIIFES ERRGLTFWQT LNEVKNENIL LSQRNDKSFL 480
  481 KSLKSFLCSI SKLENRYLSN GHSATLSDLL LGILSEIKYY EYLVRKNKET VEEKWENVME 540
  541 LVQQSDNISC IFYELDYKIS TIVLLQNFLT QIALVNEEQK EGESQKVTIS TLHAAKGLEW 600
  601 PVVFLPCLCE NIIPHSRSDD LDEERRLLYV GATRAQALLY LSSFKSVTGM FADMQNSDNV 660
  661 QDVSPFLKGE EMKRWVMESE IVFNEKIASE IGTILGRKSY GKITNLSGIG SNANHNGTKF 720
  721 ENLGFQCCRV LAEAELKKRE RVKSVNDYNK DETNFRKHNA KRSKTDIRSW FEKKQPIDSD 780
  781 VEISEPSRSA SIMVANKDLN DRSFETVNRI VSTRASTTNA SFMSSVRQNL GRGPSTKDQV 840
  841 INRTLREGHQ DVVQHTDLNQ SNTKVASARP AGSRKRLGVR LRVSRML

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] PSI-BLAST 145.0 STRUCTURE OF DNA HELICASE
    2 View Details [80..887] PSI-BLAST 42.0 RecBCD:DNA complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • pyrophosphatase activity
    		•  2.53588566650824 bayes_pls_golite062009
  • binding
    		•  2.05253348982328 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.54436515966471 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  1.51134988628578 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • helicase activity
    		•  1.16085745407703 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA binding
    		•  0.967303417236485 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.748437190903548 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.720649395550746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.59513742813869 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.58862275163252 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.554103179498056 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.514720057139153 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.514459558493013 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.489468237062011 bayes_pls_golite062009
  • bubble DNA binding
    		•  0.223451465608504 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.22150712609541 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.95561462330096E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle