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View Structure Prediction Details

Protein: srs2
Organism: Schizosaccharomyces pombe
Length: 887 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for srs2.

Description E-value Query
Range
Subject
Range
gi|56418810, gi|... - gi|56418810|ref|YP_146128.1| ATP-dependent DNA helicase [Geobacillus kaustophilus HTA426], gi|563786...
522.0 [0..5] [739..6]
gi|2625021 - gi|2625021|gb|AAC46278.1| DNA helicase II [Serratia marcescens]
522.0 [0..2] [739..1]
gi|77978540, gi|... - gi|77978540|ref|ZP_00833968.1| COG0210: Superfamily I DNA and RNA helicases [Yersinia intermedia ATC...
522.0 [0..2] [739..1]
gi|238784730, gi... - gi|77957811|ref|ZP_00821857.1| COG0210: Superfamily I DNA and RNA helicases [Yersinia bercovieri ATC...
520.0 [0..2] [739..1]
gi|77960551, gi|... - gi|77960551|ref|ZP_00824417.1| COG0210: Superfamily I DNA and RNA helicases [Yersinia mollaretii ATC...
519.0 [0..2] [738..1]
gi|238722527, gi... - gi|77973633|ref|ZP_00829179.1| COG0210: Superfamily I DNA and RNA helicases [Yersinia frederiksenii ...
518.0 [0..2] [739..1]
gi|85060320, gi|... - gi|85060320|ref|YP_456022.1| DNA-dependent helicase II [Sodalis glossinidius str. 'morsitans'], gi|8...
517.0 [0..2] [739..1]
gi|83590844, gi|... - gi|83590844|ref|YP_430853.1| ATP-dependent DNA helicase PcrA [Moorella thermoacetica ATCC 39073], gi...
514.0 [0..1] [738..1]
gi|75177773 - gi|75177773|ref|ZP_00697838.1| COG0210: Superfamily I DNA and RNA helicases [Shigella boydii BS512]
514.0 [0..2] [739..19]
gi|75238266 - gi|75238266|ref|ZP_00722265.1| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli E11001...
gi|75197699 - gi|75197699|ref|ZP_00707769.1| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli HS]
513.0 [0..2] [739..19]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METKSSYLKF LNEEQRISVQ SPHKYTQILA GPGSGKTRVL TARVAYLLQK NHIAAEDLII  60
   61 ATFTNKAANE IKLRIEAIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 145.0
Match: 1pjrA
Description: STRUCTURE OF DNA HELICASE
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [80-887]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNSEASKLIS GTFHSIAYKY LVKYGKHIGL SSNWLIADRN DTQAIMKRLL DSLKKAKNPI  60
   61 ASGIRGQELT PQNALNRITK LKSNGLLVKP GMDQLSLING LEEPPKELQS HQSVELYRLY 120
  121 QTSLWKNNLA DFDDLLLNFI LLLQKQPDCV RNIKHILIDE FQDTSKIQYF LVKLLALQNS 180
  181 DITIVGDPDQ SIYGFRSAEI RNLNQMSEDF EGTQVLHLER NYRSAKPILE LALSIISQDK 240
  241 SRPKKGLKSN HISSLKPHYR LFETNNKESY WIAREIKRIV GSCPELIFYN DIAILVRSSS 300
  301 LTRSLEHALS ELGVPYRMVG VNKFFDREEI RDLIAYLRVL ANKDSTSLIR VINVPPRNIG 360
  361 KTKIDRIIFE SERRGLTFWQ TLNEVKNENI LLSQRNDKSF LKSLKSFLCS ISKLENRYLS 420
  421 NGHSATLSDL LLGILSEIKY YEYLVRKNKE TVEEKWENVM ELVQQSDNIS CIFYELDYKI 480
  481 STIVLLQNFL TQIALVNEEQ KEGESQKVTI STLHAAKGLE WPVVFLPCLC ENIIPHSRSD 540
  541 DLDEERRLLY VGATRAQALL YLSSFKSVTG MFADMQNSDN VQDVSPFLKG EEMKRWVMES 600
  601 EIVFNEKIAS EIGTILGRKS YGKITNLSGI GSNANHNGTK FENLGFQCCR VLAEAELKKR 660
  661 ERVKSVNDYN KDETNFRKHN AKRSKTDIRS WFEKKQPIDS DVEISEPSRS ASIMVANKDL 720
  721 NDRSFETVNR IVSTRASTTN ASFMSSVRQN LGRGPSTKDQ VINRTLREGH QDVVQHTDLN 780
  781 QSNTKVASAR PAGSRKRLGV RLRVSRML

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.0
Match: 1w36B
Description: RecBCD:DNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pyrophosphatase activity 2.53588566650824 bayes_pls_golite062009
binding 2.05253348982328 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.54436515966471 bayes_pls_golite062009
DNA clamp loader activity 1.51134988628578 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
helicase activity 1.16085745407703 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
transcription regulator activity 0.748437190903548 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
structure-specific DNA binding 0.720649395550746 bayes_pls_golite062009
ATP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
double-stranded DNA binding 0.58862275163252 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.554103179498056 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.514720057139153 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.514459558493013 bayes_pls_golite062009
microtubule motor activity 0.489468237062011 bayes_pls_golite062009
bubble DNA binding 0.223451465608504 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.22150712609541 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
DNA polymerase activity 4.95561462330096E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle