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Protein Overview: SPAC12G12.16c

General Information:
Name(s) found: SPAC12G12.16c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • nuclease, XP-G family [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 496 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: DNA repair [ISSLink to PubMed article]
    Molecular Function: magnesium ion binding [IEA]
    DNA binding [IEA]
    endonuclease activity [IEA]
    nuclease activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVHGLLPII RKVASEGIRW LQPEFFSKYY PVLAVDGNLL LYRFFRSPNT PLHTNYQHVL  60
   61 WALKLSRYCR KLKTSPIVVF DNLKPNDFKA EEHEKRSLIS SQIVNQRQVV QEQMYFLCNL 120
  121 KNCLIDNNFP TGNFYYEIGP LLSQIGKLLF DLRSLNERDN PFHAQNNAEN LENATFVRLI 180
  181 VDKLNDREKT LMIQEKKNHL IHSLRQLLAF SEINDFPSEI RSYLEFILSN LDLECLTLCL 240
  241 KIIKGILTLD ELQKAIKLKQ TELDKLERRL YRPSPQNIFE IFEILKILGI PASFSPIGVE 300
  301 AEAFASAISQ NNLAYAVATQ DTDVLLLGSS MISNFLDLND NFHLPLQIMD PRKIAQELNL 360
  361 TFDGFQDYCL MCGTDFTSRI PKIGPVRALK LIRYYGNAFD VLKALNVEEK YIIPTDYIKK 420
  421 FLTAKKLFTD LPSNNELFSF IHNIPKEFLH LSDSTYLDLE KQVLRIFNVQ IEELDAKTPW 480
  481 YYHYELEKDV KSTYEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] FFAS03 3.35 FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
    2 View Details [138..496] PSI-BLAST 75.0 Crystal structure of the human FEN1-PCNA complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • deoxyribonuclease activity
    		•  2.73550697470983 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  2.71246687883519 bayes_pls_golite062009
  • flap endonuclease activity
    		•  2.57978498366847 bayes_pls_golite062009
  • exonuclease activity
    		•  2.5547866916853 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  1.89867863692111 bayes_pls_golite062009
  • nuclease activity
    		•  1.55313849436792 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  1.51267299365568 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.49423176639724 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.46099479323619 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35135691094584 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.29436272977333 bayes_pls_golite062009
  • catalytic activity
    		•  1.27951740231695 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  0.909711005599461 bayes_pls_golite062009
  • binding
    		•  0.829502253184465 bayes_pls_golite062009
  • endonuclease activity
    		•  0.819522430383345 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  0.755216908246722 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.663928021509711 bayes_pls_golite062009
  • DNA binding
    		•  0.607628194622979 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  0.483195709033192 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.352293351244824 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.250836277698583 bayes_pls_golite062009
  • protein binding
    		•  0.235717056815183 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.195644127216695 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.0488381805790525 bayes_pls_golite062009
    2
    Term Confidence Notes
  • flap endonuclease activity
    		•  3.33299970358696 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.91303769651266 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  1.57727010389968 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  1.37762008199118 bayes_pls_golite062009
  • endonuclease activity
    		•  1.29708459961264 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.1643154824625 bayes_pls_golite062009
  • exonuclease activity
    		•  1.09514726884404 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.933238209682018 bayes_pls_golite062009
  • binding
    		•  0.835604503331911 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  0.793329973341495 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.745035954521053 bayes_pls_golite062009
  • DNA binding
    		•  0.712460398759799 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.632303740950726 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.620251812982006 bayes_pls_golite062009
  • catalytic activity
    		•  0.60409960326459 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  0.547465794501352 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.325190032018196 bayes_pls_golite062009
  • protein binding
    		•  0.236485289446406 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0396334299858469 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle