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View Structure Prediction Details

Protein: SPAC12G12.16c
Organism: Schizosaccharomyces pombe
Length: 496 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC12G12.16c.

Description E-value Query
Range
Subject
Range
gi|157745509 - gi|157745509|ref|XP_001667851.1| Hypothetical protein CBG14945 [Caenorhabditis briggsae AF16]
FEN1_CAEBR - Flap endonuclease 1 OS=Caenorhabditis briggsae GN=crn-1 PE=3 SV=1
296.0 [0..138] [484..3]
gi|26345786 - gi|26345786|dbj|BAC36544.1| unnamed protein product [Mus musculus]
291.0 [0..138] [484..3]
FEN1A_DANRE - Flap endonuclease 1 OS=Danio rerio GN=fen1 PE=2 SV=1
290.0 [0..138] [484..3]
FEN1_CHICK - Flap endonuclease 1 OS=Gallus gallus GN=FEN1 PE=2 SV=1
290.0 [0..138] [484..3]
FEN1_XIPMA - Flap endonuclease 1 OS=Xiphophorus maculatus GN=fen1 PE=2 SV=1
290.0 [0..138] [484..3]
gi|85094661 - gi|85094661|ref|XP_959932.1| hypothetical protein [Neurospora crassa OR74A]
gi|28921389, gi|... - gi|32421241|ref|XP_331064.1| hypothetical protein [Neurospora crassa], gi|28921389|gb|EAA30696.1| hy...
290.0 [0..137] [492..579]
gi|62859561 - gi|62859561|ref|NP_001017005.1| flap structure specific endonuclease 1 [Xenopus (Silurana) tropicali...
289.0 [0..138] [484..3]
FEN1_RAT - Flap endonuclease 1 OS=Rattus norvegicus GN=Fen1 PE=2 SV=1
289.0 [0..138] [484..3]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVHGLLPII RKVASEGIRW LQPEFFSKYY PVLAVDGNLL LYRFFRSPNT PLHTNYQHVL  60
   61 WALKLSRYCR KLKTSPIVVF DNLKPNDFKA EEHEKRSLIS SQIVNQRQVV QEQMYFLCNL 120
  121 KNCLIDNNFP TGNFYYE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.35
Match: 1a76A
Description: FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
deoxyribonuclease activity 2.73550697470983 bayes_pls_golite062009
endodeoxyribonuclease activity 2.71246687883519 bayes_pls_golite062009
flap endonuclease activity 2.57978498366847 bayes_pls_golite062009
exonuclease activity 2.5547866916853 bayes_pls_golite062009
5'-3' exonuclease activity 1.89867863692111 bayes_pls_golite062009
nuclease activity 1.55313849436792 bayes_pls_golite062009
exodeoxyribonuclease activity 1.51267299365568 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.49423176639724 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.46099479323619 bayes_pls_golite062009
hydrolase activity 1.35135691094584 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.29436272977333 bayes_pls_golite062009
catalytic activity 1.27951740231695 bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity 0.909711005599461 bayes_pls_golite062009
binding 0.829502253184465 bayes_pls_golite062009
endonuclease activity 0.819522430383345 bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity 0.755216908246722 bayes_pls_golite062009
nucleic acid binding 0.663928021509711 bayes_pls_golite062009
DNA binding 0.607628194622979 bayes_pls_golite062009
5'-flap endonuclease activity 0.483195709033192 bayes_pls_golite062009
damaged DNA binding 0.352293351244824 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.250836277698583 bayes_pls_golite062009
protein binding 0.235717056815183 bayes_pls_golite062009
structure-specific DNA binding 0.195644127216695 bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.0488381805790525 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [138-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGPLLSQIGK LLFDLRSLNE RDNPFHAQNN AENLENATFV RLIVDKLNDR EKTLMIQEKK  60
   61 NHLIHSLRQL LAFSEINDFP SEIRSYLEFI LSNLDLECLT LCLKIIKGIL TLDELQKAIK 120
  121 LKQTELDKLE RRLYRPSPQN IFEIFEILKI LGIPASFSPI GVEAEAFASA ISQNNLAYAV 180
  181 ATQDTDVLLL GSSMISNFLD LNDNFHLPLQ IMDPRKIAQE LNLTFDGFQD YCLMCGTDFT 240
  241 SRIPKIGPVR ALKLIRYYGN AFDVLKALNV EEKYIIPTDY IKKFLTAKKL FTDLPSNNEL 300
  301 FSFIHNIPKE FLHLSDSTYL DLEKQVLRIF NVQIEELDAK TPWYYHYELE KDVKSTYEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.0
Match: 1ul1X
Description: Crystal structure of the human FEN1-PCNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
flap endonuclease activity 3.33299970358696 bayes_pls_golite062009
endodeoxyribonuclease activity 3.29138075959109 bayes_pls_golite062009
deoxyribonuclease activity 3.25110450559975 bayes_pls_golite062009
exodeoxyribonuclease activity 2.0005433655378 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.9833086883205 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.91303769651266 bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity 1.57727010389968 bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity 1.37762008199118 bayes_pls_golite062009
endonuclease activity 1.29708459961264 bayes_pls_golite062009
5'-flap endonuclease activity 1.1643154824625 bayes_pls_golite062009
exonuclease activity 1.09514726884404 bayes_pls_golite062009
5'-3' exonuclease activity 0.933238209682018 bayes_pls_golite062009
binding 0.835604503331911 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 0.793329973341495 bayes_pls_golite062009
nucleic acid binding 0.745035954521053 bayes_pls_golite062009
DNA binding 0.712460398759799 bayes_pls_golite062009
damaged DNA binding 0.632303740950726 bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.620251812982006 bayes_pls_golite062009
catalytic activity 0.60409960326459 bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity 0.547465794501352 bayes_pls_golite062009
structure-specific DNA binding 0.325190032018196 bayes_pls_golite062009
protein binding 0.236485289446406 bayes_pls_golite062009
hydrolase activity 0.0396334299858469 bayes_pls_golite062009

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