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Protein Overview: rpn6

General Information:
Name(s) found: rpn6 / SPAC23G3.11 [Sanger Pombe]
Description(s) found:
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  • gi|6912028|emb|CAB72236.1| 19S proteasome regulatory subunit Rpn6 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|20978741|sp|Q9P7S2.1|RPN6_SCHPO RecName: Full=Probable 26S proteasome regulatory subunit rpn6 [NCBI NR]
  • gi|19114023|ref|NP_593111.1| 19S proteasome regulatory subunit Rpn6 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|11280490|pir||T50185 26S proteasome regulatory subunit [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • 19S proteasome regulatory subunit Rpn6 [Sanger Pombe]
  • Probable 26S proteasome regulatory subunit rpn6 OS=Schizosaccharomyces pombe GN=rpn6 PE=2 SV=1 [Swiss-Prot]
  • 19S PROTEASOME REGULATORY SUBUNIT: Q9P7S2; [pompepVF.fasta]
  • 19S PROTEASOME REGULATORY: Q9P7S2; [pompepV13]
  • Probable 26S proteasome regulatory subunit rpn6 [pompep4896]
  • |rpn6||19S proteasome regulatory subunit [pompepnew.fasta]
  • |rpn6||19S proteasome regulatory subunit|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • 26S proteasome regulatory subunit [Schizosaccharomyces pombe]gi|6912028|emb|CAB72236.1| SPAC23G3.11 [Schizosaccharomyces pombe]gi|20978741|sp|Q9P7S2|RPN6_SCHPO Probable 26S proteasome regulatory subunit rpn6gi|11280490|pir||T50185 26S proteasome regula [nrdb_11152004_Chlamydomonas]
  • (Q9P7S2) Probable 26S proteasome regulatory subunit rpn6 [pompep4896_normal_reversed]
  • |rpn6||19S proteasome regulatory subunit Rpn6 |Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC23G3.11 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC23G3.11 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Probable 26S proteasome regulatory subunit rpn6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rpn6 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 421 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    proteasome regulatory particle, base subcomplex [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of cell cycle [RCALink to PubMed article]
    mitotic cell cycle [IC]
    ubiquitin-dependent protein catabolic process [ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKSSLELA NNAVKSNDIE KAIDLYKEVL NKGVSKDEKV ANEQEQALTN LSDLYVRENR  60
   61 HNDLAQLVQQ SRPLMANFSK AKSAKIVRTL IDKFSGEKKS LPLQIEVAND CIKWAIKEKR 120
  121 TFLRQALETK LISLYYDNSS YTDAINLINT LLSELKRMDD KMLLTEVHLL ESKVYHAIRN 180
  181 IPKARASLTA AKTSANAVYC PPMLQGNLDL QSGILHADDM DFKTAYSYFY EAYEGFTSLD 240
  241 DDKKALSSLK YMLLSQIMLN SVSEVKSLLT GKHAIRYAGR DIEAMRAIAQ AHENRSLADF 300
  301 EKALQDYKPE LASDPIIRSH LSSLYDNLLE QNLLRVVEPF SRVEVSHIAE LIGLSTVQVE 360
  361 GKLSQMILDK IFYGILDQGS GCLIVYDEPQ QDKTYEAALE VIKNMGTVVD LLIENKASAL 420
  421 L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..313] PSI-BLAST 15.69897 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    2 View Details [314..421] PSI-BLAST 9.0 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.78419126863783 bayes_pls_golite062009
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36571535004008 bayes_pls_golite062009
  • DNA binding
    		•  1.95874073664777 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.72745783719415 bayes_pls_golite062009
  • protein binding
    		•  1.6279032205159 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.41858884169884 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21805666483342 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.532407342912695 bayes_pls_golite062009
  • transcription factor binding
    		•  0.518146612491969 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.476530460247536 bayes_pls_golite062009
  • enzyme binding
    		•  0.44905827271946 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.38161635991367 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30464889749774 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0593768116971065 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.69183445184264 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.48053910222825 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • hydrolase activity
    		•  2.30467124306022 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.46680509390433 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.181186586600235 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.136726704233672 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.118016217031359 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.0360186926687502 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle