YRC Public Data Repository - Protein Structure Prediction

Protein:	rpn6
Organism:	Schizosaccharomyces pombe
Length:	421 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rpn6.

Description	E-value	Query Range	Subject Range
gi\|49093802, gi\|... - gi\|67527965\|ref\|XP_661829.1\| hypothetical protein AN4225.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	226.0	[0..3]	[407..7]
gi\|90302859, gi\|... - gi\|90302859\|gb\|EAS32490.1\| hypothetical protein CIMG_03514 [Coccidioides immitis RS], gi\|119186933\|r...	209.0	[0..2]	[420..7]
gi\|66848011, gi\|... - gi\|70991060\|ref\|XP_750379.1\| proteasome regulatory particle subunit (RpnF) [Aspergillus fumigatus A...	208.0	[0..4]	[420..55]
gi\|91090690 - gi\|91090690\|ref\|XP_974687.1\| PREDICTED: similar to CG10149-PA, isoform A [Tribolium castaneum]	207.0	[0..1]	[418..214]
gi\|169623421, gi... - gi\|169623421\|ref\|XP_001805118.1\| hypothetical protein SNOG_14950 [Phaeosphaeria nodorum SN15], gi\|11...	204.0	[0..12]	[420..14]
gi\|83766797 - gi\|83766797\|dbj\|BAE56937.1\| unnamed protein product [Aspergillus oryzae] gi\|169768938 - gi\|169768938\|ref\|XP_001818939.1\| hypothetical protein [Aspergillus oryzae RIB40]	203.0	[0..4]	[420..8]
gi\|109488638 - gi\|109488638\|ref\|XP_220754.3\| PREDICTED: similar to 26S proteasome non-ATPase regulatory subunit 11 ...	203.0	[0..1]	[418..78]
gi\|88176336, gi\|... - gi\|88176336\|gb\|EAQ83804.1\| hypothetical protein CHGG_10208 [Chaetomium globosum CBS 148.51], gi\|1162...	200.0	[0..12]	[420..13]
gi\|125590511, gi... - gi\|50924558\|ref\|XP_472639.1\| OSJNBa0058G03.7 [Oryza sativa (japonica cultivar-group)], gi\|38344584\|e...	199.0	[0..12]	[420..18]

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Predicted Domain #1

Region A:
Residues: [1-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKSSLELA NNAVKSNDIE KAIDLYKEVL NKGVSKDEKV ANEQEQALTN LSDLYVRENR  60
   61 HNDLAQLVQQ SRPLMANFSK AKSAKIVRTL IDKFSGEKKS LPLQIEVAND CIKWAIKEKR 120
  121 TFLRQALETK LISLYYDNSS YTDAINLINT LLSELKRMDD KMLLTEVHLL ESKVYHAIRN 180
  181 IPKARASLTA AKTSANAVYC PPMLQGNLDL QSGILHADDM DFKTAYSYFY EAYEGFTSLD 240
  241 DDKKALSSLK YMLLSQIMLN SVSEVKSLLT GKHAIRYAGR DIEAMRAIAQ AHENRSLADF 300
  301 EKALQDYKPE LAS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1w3bA
Description:	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.78419126863783	bayes_pls_golite062009
binding	2.71974493738804	bayes_pls_golite062009
transcription regulator activity	2.36571535004008	bayes_pls_golite062009
DNA binding	1.95874073664777	bayes_pls_golite062009
nucleic acid binding	1.72745783719415	bayes_pls_golite062009
protein binding	1.6279032205159	bayes_pls_golite062009
transcription repressor activity	1.41858884169884	bayes_pls_golite062009
transcription factor activity	1.21805666483342	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.532407342912695	bayes_pls_golite062009
transcription factor binding	0.518146612491969	bayes_pls_golite062009
small conjugating protein ligase activity	0.476530460247536	bayes_pls_golite062009
enzyme binding	0.44905827271946	bayes_pls_golite062009
unfolded protein binding	0.38161635991367	bayes_pls_golite062009
transcription cofactor activity	0.30464889749774	bayes_pls_golite062009
transcription activator activity	0.0593768116971065	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [314-421]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPIIRSHLSS LYDNLLEQNL LRVVEPFSRV EVSHIAELIG LSTVQVEGKL SQMILDKIFY  60
   61 GILDQGSGCL IVYDEPQQDK TYEAALEVIK NMGTVVDLLI ENKASALL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.0
Match:	1ufmA
Description:	Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	5.55329976718261	bayes_pls_golite062009
DNA binding	5.08959163553491	bayes_pls_golite062009
nucleic acid binding	4.69183445184264	bayes_pls_golite062009
transcription factor activity	4.33152142980289	bayes_pls_golite062009
transcription repressor activity	3.85678231380989	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.60738445921725	bayes_pls_golite062009
sequence-specific DNA binding	2.48053910222825	bayes_pls_golite062009
transcription activator activity	2.37668609508629	bayes_pls_golite062009
hydrolase activity	2.30467124306022	bayes_pls_golite062009
structural constituent of ribosome	1.46680509390433	bayes_pls_golite062009
specific transcriptional repressor activity	0.96257232341735	bayes_pls_golite062009
transcription factor binding	0.85714789329232	bayes_pls_golite062009
protein binding	0.753698599635855	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.66743181561551	bayes_pls_golite062009
transcription corepressor activity	0.322180400748724	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.181186586600235	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.136726704233672	bayes_pls_golite062009
small conjugating protein ligase activity	0.118016217031359	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.0360186926687502	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: