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Protein Overview: pot1

General Information:
Name(s) found: pot1 / SPAC26H5.06 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • telomere end-binding protein Pot1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 555 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    telosome [ICLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: chromosome segregation [IMPLink to PubMed article]
    telomere maintenance via telomerase [IMPLink to PubMed article]
    telomere capping [IDALink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    single-stranded telomeric DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK DFTPSRQSLH  60
   61 GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ VGQPLLLHQI TLRSYRDRTQ 120
  121 GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE 180
  181 LLSTSSARQN QTGLSYPSVS FSLLSQITPH QRCSFYAQVI KTWYSDKNFT LYVTDYTENE 240
  241 LFFPMSPYTS SSRWRGPFGR FSIRCILWDE HDFYCRNYIK EGDYVVMKNV RTKIDHLGYL 300
  301 ECILHGDSAK RYNMSIEKVD SEEPELNEIK SRKRLYVQNC QNGIEAVIEK LSQSQQSENP 360
  361 FIAHELKQTS VNEITAHVIN EPASLKLTTI STILHAPLQN LLKPRKHRLR VQVVDFWPKS 420
  421 LTQFAVLSQP PSSYVWMFAL LVRDVSNVTL PVIFFDSDAA ELINSSKIQP CNLADHPQMT 480
  481 LQLKERLFLI WGNLEERIQH HISKGESPTL AAEDVETPWF DIYVKEYIPV IGNTKDHQSL 540
  541 TFLQKRWRGF GTKIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] PSI-BLAST 56.0 Crystal structure of Pot1 (protection of telomere)- ssDNA complex
    2 View Details [197..356] FFAS03 3.15 Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)
    3 View Details [357..445] MSA 2.03399 View MSA. No confident structure predictions are available.
    4 View Details [446..555] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • single-stranded telomeric DNA binding
    		•  7.13197590913268 bayes_pls_golite062009
  • telomeric DNA binding
    		•  7.07761964836826 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  6.44640500235314 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.27576062206528 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.06066809614422 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.0183551365402 bayes_pls_golite062009
  • binding
    		•  2.63617204791771 bayes_pls_golite062009
  • DNA binding
    		•  2.56243510083541 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.13063800565247 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  1.99143471576874 bayes_pls_golite062009
  • structural molecule activity
    		•  1.9177190829469 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.12203697857261 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.756094573447167 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.638831894247026 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.62994126331969 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.491028860958185 bayes_pls_golite062009
  • translation regulator activity
    		•  0.31332179848255 bayes_pls_golite062009
  • exonuclease activity
    		•  0.28313884527829 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.263197317040851 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.21650406007586 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.2080607201312 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.10868826895563 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.10868826895563 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0591886273075271 bayes_pls_golite062009
  • protein binding
    		•  0.0528188351789111 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.0179535526984695 bayes_pls_golite062009
  • helicase activity
    		•  0.0121541775159524 bayes_pls_golite062009
    2
    Term Confidence Notes
  • telomeric DNA binding
    		•  6.80354805962079 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  6.768584842828 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  6.18497827074251 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.06958664528424 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.74795067107907 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  2.64392934015868 bayes_pls_golite062009
  • binding
    		•  2.55343783977289 bayes_pls_golite062009
  • DNA binding
    		•  2.39520356118846 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.93610624899943 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  1.78477061484084 bayes_pls_golite062009
  • structural molecule activity
    		•  1.75354740531381 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.03434608237928 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.786603442061911 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.633347054314125 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.451086694866543 bayes_pls_golite062009
  • nuclease activity
    		•  0.344602655860014 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.327087435405429 bayes_pls_golite062009
  • exonuclease activity
    		•  0.123437412322173 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.112654475341878 bayes_pls_golite062009
  • protein binding
    		•  0.0856707433885143 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0739391344707232 bayes_pls_golite062009
  • translation regulator activity
    		•  0.0701407719982948 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.0194971183869158 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle