YRC Public Data Repository - Protein Structure Prediction

Protein:	pot1
Organism:	Schizosaccharomyces pombe
Length:	555 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pot1.

Description	E-value	Query Range	Subject Range
gi\|7491013 - gi\|7491013\|pir\|\|T38425 hypothetical protein SPAC26H5.06 - fission yeast (Schizosaccharomyces pombe)	640.0	[0..24]	[555..4]
gi\|33412002 - gi\|33412002\|emb\|CAE00179.1\| Pot1-like protein [Emericella nidulans]	502.0	[0..25]	[554..8]
gi\|39971491, gi\|... - gi\|39971491\|ref\|XP_367136.1\| hypothetical protein MGG_07061 [Magnaporthe grisea 70-15], gb\|EAA56706....	458.0	[0..39]	[554..33]
gi\|45385171 - gi\|45385171\|gb\|AAS59561.1\| Pot1-like protein [Arabidopsis thaliana]	455.0	[0..28]	[555..9]
gi\|16944476 - gi\|16944476\|emb\|CAD11392.1\| conserved hypothetical protein [Neurospora crassa]	448.0	[0..16]	[554..67]
gi\|85098690 - gi\|85098690\|ref\|XP_960651.1\| hypothetical protein ( (AL513442) conserved hypothetical protein [Neuro... gi\|28922163, gi\|... - gi\|32412522\|ref\|XP_326741.1\| hypothetical protein ( (AL513442) conserved hypothetical protein [Neuro...	446.0	[0..16]	[554..56]

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Predicted Domain #1

Region A:
Residues: [1-196]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK DFTPSRQSLH  60
   61 GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ VGQPLLLHQI TLRSYRDRTQ 120
  121 GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE 180
  181 LLSTSSARQN QTGLSY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.0
Match:	1qzgA
Description:	Crystal structure of Pot1 (protection of telomere)- ssDNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
single-stranded telomeric DNA binding	7.13197590913268	bayes_pls_golite062009
telomeric DNA binding	7.07761964836826	bayes_pls_golite062009
telomerase inhibitor activity	6.44640500235314	bayes_pls_golite062009
nucleic acid binding	3.27576062206528	bayes_pls_golite062009
structure-specific DNA binding	3.06066809614422	bayes_pls_golite062009
single-stranded DNA binding	3.0183551365402	bayes_pls_golite062009
binding	2.63617204791771	bayes_pls_golite062009
DNA binding	2.56243510083541	bayes_pls_golite062009
structural constituent of ribosome	2.13063800565247	bayes_pls_golite062009
DEAD/H-box RNA helicase binding	1.99143471576874	bayes_pls_golite062009
structural molecule activity	1.9177190829469	bayes_pls_golite062009
DNA helicase activity	1.12203697857261	bayes_pls_golite062009
transcription regulator activity	0.756094573447167	bayes_pls_golite062009
DNA-dependent ATPase activity	0.638831894247026	bayes_pls_golite062009
ribonuclease activity	0.62994126331969	bayes_pls_golite062009
nuclease activity	0.57381531077345	bayes_pls_golite062009
nucleotidyltransferase activity	0.491028860958185	bayes_pls_golite062009
translation regulator activity	0.31332179848255	bayes_pls_golite062009
exonuclease activity	0.28313884527829	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.263197317040851	bayes_pls_golite062009
sequence-specific DNA binding	0.21650406007586	bayes_pls_golite062009
translation initiation factor activity	0.2080607201312	bayes_pls_golite062009
RNA polymerase activity	0.10868826895563	bayes_pls_golite062009
DNA-directed RNA polymerase activity	0.10868826895563	bayes_pls_golite062009
transcription factor activity	0.0591886273075271	bayes_pls_golite062009
protein binding	0.0528188351789111	bayes_pls_golite062009
ATP-dependent DNA helicase activity	0.0179535526984695	bayes_pls_golite062009
helicase activity	0.0121541775159524	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [197-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSVSFSLLSQ ITPHQRCSFY AQVIKTWYSD KNFTLYVTDY TENELFFPMS PYTSSSRWRG  60
   61 PFGRFSIRCI LWDEHDFYCR NYIKEGDYVV MKNVRTKIDH LGYLECILHG DSAKRYNMSI 120
  121 EKVDSEEPEL NEIKSRKRLY VQNCQNGIEA VIEKLSQSQQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.15
Match:	1xjvA
Description:	Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
telomeric DNA binding	6.80354805962079	bayes_pls_golite062009
single-stranded telomeric DNA binding	6.768584842828	bayes_pls_golite062009
telomerase inhibitor activity	6.18497827074251	bayes_pls_golite062009
nucleic acid binding	3.06958664528424	bayes_pls_golite062009
structure-specific DNA binding	2.74795067107907	bayes_pls_golite062009
single-stranded DNA binding	2.64392934015868	bayes_pls_golite062009
binding	2.55343783977289	bayes_pls_golite062009
DNA binding	2.39520356118846	bayes_pls_golite062009
structural constituent of ribosome	1.93610624899943	bayes_pls_golite062009
DEAD/H-box RNA helicase binding	1.78477061484084	bayes_pls_golite062009
structural molecule activity	1.75354740531381	bayes_pls_golite062009
DNA helicase activity	1.03434608237928	bayes_pls_golite062009
transcription regulator activity	0.786603442061911	bayes_pls_golite062009
DNA-dependent ATPase activity	0.633347054314125	bayes_pls_golite062009
nucleotidyltransferase activity	0.451086694866543	bayes_pls_golite062009
nuclease activity	0.344602655860014	bayes_pls_golite062009
ribonuclease activity	0.327087435405429	bayes_pls_golite062009
exonuclease activity	0.123437412322173	bayes_pls_golite062009
sequence-specific DNA binding	0.112654475341878	bayes_pls_golite062009
protein binding	0.0856707433885143	bayes_pls_golite062009
transcription factor activity	0.0739391344707232	bayes_pls_golite062009
translation regulator activity	0.0701407719982948	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.0194971183869158	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [357-445]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SENPFIAHEL KQTSVNEITA HVINEPASLK LTTISTILHA PLQNLLKPRK HRLRVQVVDF  60
   61 WPKSLTQFAV LSQPPSSYVW MFALLVRDV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [446-555]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNVTLPVIFF DSDAAELINS SKIQPCNLAD HPQMTLQLKE RLFLIWGNLE ERIQHHISKG  60
   61 ESPTLAAEDV ETPWFDIYVK EYIPVIGNTK DHQSLTFLQK RWRGFGTKIV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: