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Protein Overview: myh1

General Information:
Name(s) found: myh1 / SPAC26A3.02 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • adenine DNA glycosylase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 461 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ICLink to PubMed article][IDALink to PubMed article]
    Biological Process: DNA damage checkpoint [IGILink to PubMed article]
    DNA repair [ICLink to PubMed article]
    base-excision repair [ICLink to PubMed article]
    cellular response to UV [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    iron ion binding [IEA]
    endonuclease activity [IEA]
    oxidized base lesion DNA N-glycosylase activity [TASLink to PubMed article]
    purine-specific mismatch base pair DNA N-glycosylase activity [IMPLink to PubMed article]
    DNA N-glycosylase activity [IDALink to PubMed article]
    4 iron, 4 sulfur cluster binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSNHSLDL HSYTQLEVER FRESLIQFYD KTKRILPWRK KECIPPSEDS PLEDWEQPVQ  60
   61 RLYEVLVSEI MLQQTRVETV KRYYTKWMET LPTLKSCAEA EYNTQVMPLW SGMGFYTRCK 120
  121 RLHQACQHLA KLHPSEIPRT GDEWAKGIPG VGPYTAGAVL SIAWKQPTGI VDGNVIRVLS 180
  181 RALAIHSDCS KGKANALIWK LANELVDPVR PGDFNQALME LGAITCTPQS PRCSVCPISE 240
  241 ICKAYQEQNV IRDGNTIKYD IEDVPCNICI TDIPSKEDLQ NWVVARYPVH PAKTKQREER 300
  301 ALVVIFQKTD PSTKEKFFLI RKRPSAGLLA GLWDFPTIEF GQESWPKDMD AEFQKSIAQW 360
  361 ISNDSRSLIK KYQSRGRYLH IFSHIRKTSH VFYAIASPDI VTNEDFFWIS QSDLEHVGMC 420
  421 ELGLKNYRAA LEIKKRKVTS LSNFKEPKLT SARRIVTKAE C

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..461] PSI-BLAST 75.69897 MutY adenine glycosylase in complex with DNA containing an abasic site

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.71152530486175 bayes_pls_golite062009
  • MutLbeta complex binding
    		•  3.54991362477413 bayes_pls_golite062009
  • MutSbeta complex binding
    		•  3.54991362477413 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  2.49872706126491 bayes_pls_golite062009
  • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
    		•  2.21048599823382 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.00388798014411 bayes_pls_golite062009
  • hydrolase activity
    		•  1.97832429767892 bayes_pls_golite062009
  • DNA binding
    		•  1.70910448624199 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.5832578018127 bayes_pls_golite062009
  • catalytic activity
    		•  1.49075808737475 bayes_pls_golite062009
  • binding
    		•  1.39782212043388 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  1.32985950765371 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  1.2016453685638 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.06392208444166 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.06383943982125 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.953912155797942 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.879508131574476 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.85419760398899 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.68578837518217 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.661651574677137 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.57099109384393 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.546676461152337 bayes_pls_golite062009
  • transcription factor activity
    		•  0.181268475863531 bayes_pls_golite062009
  • protein binding
    		•  0.114897414738363 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0676784802238829 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.00783582682768413 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle