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View Structure Prediction Details

Protein: myh1
Organism: Schizosaccharomyces pombe
Length: 461 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for myh1.

Description E-value Query
Range
Subject
Range
gi|3628759, gi|1... - gi|3628759|gb|AAC36207.1| A/G-specific adenine DNA glycosylase [Schizosaccharomyces pombe], pir||T43...
406.0 [0..1] [461..1]
MUTYH_MOUSE - Adenine DNA glycosylase OS=Mus musculus GN=Mutyh PE=2 SV=2
348.0 [0..10] [449..55]
gi|119627404, gi... - gi|6691529|dbj|BAA89340.1| hMYHbeta1 [Homo sapiens], gi|119627404|gb|EAX06999.1| mutY homolog (E. co...
347.0 [0..10] [449..67]
gi|114556221, gi... - gi|114556225|ref|XP_001155712.1| PREDICTED: mutY homolog isoform 7 [Pan troglodytes], gi|114556223|r...
346.0 [0..10] [449..56]

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Predicted Domain #1
Region A:
Residues: [1-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSNHSLDL HSYTQLEVER FRESLIQFYD KTKRILPWRK KECIPPSEDS PLEDWEQPVQ  60
   61 RLYEVLVSEI MLQQTRVETV KRYYTKWMET LPTLKSCAEA EYNTQVMPLW SGMGFYTRCK 120
  121 RLHQACQHLA KLHPSEIPRT GDEWAKGIPG VGPYTAGAVL SIAWKQPTGI VDGNVIRVLS 180
  181 RALAIHSDCS KGKANALIWK LANELVDPVR PGDFNQALME LGAITCTPQS PRCSVCPISE 240
  241 ICKAYQEQNV IRDGNTIKYD IEDVPCNICI TDIPSKEDLQ NWVVARYPVH PAKTKQREER 300
  301 ALVVIFQKTD PSTKEKFFLI RKRPSAGLLA GLWDFPTIEF GQESWPKDMD AEFQKSIAQW 360
  361 ISNDSRSLIK KYQSRGRYLH IFSHIRKTSH VFYAIASPDI VTNEDFFWIS QSDLEHVGMC 420
  421 ELGLKNYRAA LEIKKRKVTS LSNFKEPKLT SARRIVTKAE C

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 75.69897
Match: 1rrsA
Description: MutY adenine glycosylase in complex with DNA containing an abasic site
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA-(apurinic or apyrimidinic site) lyase activity 3.71152530486175 bayes_pls_golite062009
MutLbeta complex binding 3.54991362477413 bayes_pls_golite062009
MutSbeta complex binding 3.54991362477413 bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity 2.49872706126491 bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity 2.21048599823382 bayes_pls_golite062009
damaged DNA binding 2.00388798014411 bayes_pls_golite062009
hydrolase activity 1.97832429767892 bayes_pls_golite062009
DNA binding 1.70910448624199 bayes_pls_golite062009
alkylbase DNA N-glycosylase activity 1.5832578018127 bayes_pls_golite062009
catalytic activity 1.49075808737475 bayes_pls_golite062009
binding 1.39782212043388 bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity 1.32985950765371 bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity 1.2016453685638 bayes_pls_golite062009
nucleic acid binding 1.06392208444166 bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity 1.06383943982125 bayes_pls_golite062009
transcription regulator activity 0.953912155797942 bayes_pls_golite062009
uracil DNA N-glycosylase activity 0.879508131574476 bayes_pls_golite062009
structure-specific DNA binding 0.85419760398899 bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity 0.68578837518217 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 0.661651574677137 bayes_pls_golite062009
double-stranded DNA binding 0.57099109384393 bayes_pls_golite062009
pyrophosphatase activity 0.546676461152337 bayes_pls_golite062009
transcription factor activity 0.181268475863531 bayes_pls_golite062009
protein binding 0.114897414738363 bayes_pls_golite062009
carbon-oxygen lyase activity 0.0676784802238829 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.00783582682768413 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle