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Protein Overview: mcm7

General Information:
Name(s) found: mcm7 / SPBC25D12.03c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • MCM complex subunit Mcm7 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 760 amino acids

    Gene Ontology:
    Cellular Component: replication fork [RCALink to PubMed article]
    pre-replicative complex [ICLink to PubMed article]
    DNA replication preinitiation complex [IC]
    MCM complex [IDALink to PubMed article]
    Biological Process: DNA replication initiation [IDALink to PubMed article]
    S phase of mitotic cell cycle [ICLink to PubMed article]
    DNA strand elongation involved in DNA replication [TASLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    ATP-dependent DNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALPTIDLKI PEYEECQHKI TDFLSHFKQE QVQDGQQNQD ISMSDAGDEP FLKSKYMDIL  60
   61 QKISNRESNV INVDLNDLYE FDPSDTQLLH NIESNAKRFV ELFSQCADAL MPPPTVEINY 120
  121 RNEVLDVIMQ QRVQRNENID PEHKGFPPEL TRGYDLYFRP VTRNKKPFSV RDLRGENLGS 180
  181 LLTVRGIVTR TSDVKPSLTV NAYTCDRCGY EVFQEIRQKT FLPMSECPSD ECKKNDAKGQ 240
  241 LFMSTRASKF LPFQEVKIQE LTNQVPIGHI PRSLTVHLYG AITRSVNPGD IVDISGIFLP 300
  301 TPYTGFRAMR AGLLTDTYLE CHYVSQIIKN YTNIEKTPQS EAAIAELNQG GNVYEKLAKS 360
  361 IAPEIYGHED VKKALLLLLV GGVTKELGDG MRIRGDINIC LTGDPGVAKS QLLKYISKVA 420
  421 PRGVYTTGRG SSGVGLTAAV MRDPVTDEMV LEGGALVLAD NGICCIDEFD KMDESDRTAI 480
  481 HEVMEQQTIS ISKAGITTTL NARTSILAAA NPLYGRYNPK VAPIHNINLP AALLSRFDIL 540
  541 FLILDTPSRE TDEHLAQHVT YVHMHNEQPK MDFEPLDPNM IRHYISSARQ YRPVVPKDVC 600
  601 DYVTGAYVQL RQNQKRDEAN ERQFAHTTPR TLLAILRMGQ ALARLRFSNR VEIGDVDEAL 660
  661 RLMSVSKSSL YDDLDPSSHD TTITSKIYKI IRDMLNSIPD VEGNERSLTL RAIRERVLAK 720
  721 GFTEDHLINT IQEYTDLGVL LTTNNGQTIM FLDPDLHMEN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..618] PSI-BLAST 38.69897 N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
    2 View Details [619..670] PSI-BLAST 22.69897 No description for 2qp9X was found.
    3 View Details [671..760] PSI-BLAST 50.69897 Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  4.91429252297969 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  4.80695929076807 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.66107861968804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.63960194106079 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.61735400124552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.60404584546501 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.20315703345493 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.05408274676326 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.8469248456592 bayes_pls_golite062009
  • kinase activity
    		•  0.641541011250583 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.584453361662212 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.406600732518248 bayes_pls_golite062009
  • protein kinase activity
    		•  0.351308564667977 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.26252931460003 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.243902356228423 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.156278588350022 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13366911641814 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  0.0642842984371965 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0223627159838333 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle