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Protein Overview: mcm6

General Information:
Name(s) found: mcm6 / SPBC211.04c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • MCM complex subunit Mcm6 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 892 amino acids

    Gene Ontology:
    Cellular Component: replication fork [RCALink to PubMed article]
    pre-replicative complex [ICLink to PubMed article]
    nuclear chromatin [IDALink to PubMed article]
    DNA replication preinitiation complex [IC]
    cytosol [IDALink to PubMed article]
    MCM complex [IDALink to PubMed article]
    Biological Process: DNA replication initiation [IDALink to PubMed article]
    S phase of mitotic cell cycle [ICLink to PubMed article]
    DNA strand elongation involved in DNA replication [TASLink to PubMed article]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    ATP-dependent DNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLASQGNN ASTPAYRYGF QTSEVGDRPT VSMPSQPESS AMLEDDGMVK RKPFAAIGEA  60
   61 IPKVIDTTGE SVREAFEEFL LSFSDDRVAG GDALPSASQE KYYVQQIHGL AMYEIHTVYV 120
  121 DYKHLTSYND VLALAIVEQY YRFSPFLLRA LQKLIEKFEP EYYRSSLSRE NASLSPNFKA 180
  181 SDKTFALAFY NLPFRSTIRD LRTDRIGRLT TITGTVTRTS EVRPELAQGT FICEECHTVV 240
  241 SNVEQAFRYT EPTQCPNELC ANKRSWRLNI SQSSFQDWQK VRIQENSNEI PTGSMPRTLD 300
  301 VILRGDIVER AKAGDKCAFT GILIAVPDVS QLGIPGVKPE AYRDSRNFGG RDADGVTGLK 360
  361 SLGVRDLTYK LSFLACMVQP DDANDKSGAD VRGDGSQGIE EQDEFLQSLS QEEIDDLRAM 420
  421 VHSDHIYSRL TNSLAPSVYG HEIIKKGILL QLMGGVHKLT PEGINLRGDL NICIVGDPST 480
  481 SKSQFLKYVC NFLPRAIYTS GKASSAAGLT AAVVKDEETG DFTIEAGALM LADNGICAID 540
  541 EFDKMDLSDQ VAIHEAMEQQ TISIAKAGIQ ATLNARTSIL AAANPIGGRY NRKTTLRNNI 600
  601 NMSAPIMSRF DLFFVVLDEC NESVDRHLAK HIVDIHRLRD DAMQPEFSTE QLQRYIRYAR 660
  661 TFKPKLNTES CAEIVKKYKQ LRMDDAQGAG KNSYRITVRQ LESMIRLSEA IARANCVDDI 720
  721 TPAFVNEAYS LLRQSIIHVE RDDIEVEEDD AEAQELENDN TNTTNGNDNV SSEEALQKPK 780
  781 VKITYDKYVS IMNGILQVLR QRSTEGVDGV PAGDLVQSYL ELREDQFHTE EDIIYEVGLV 840
  841 RKVLTRLVHE SIIMEIQNLT DSAVRLPFEE RVFSIHPNCD IDALLSNGDV PN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..693] PSI-BLAST 61.09691 Crystal Structure Analysis of ClpB
    2 View Details [694..892] PSI-BLAST 46.09691 EDTA treated

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  4.91429252297969 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  4.80695929076807 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.66107861968804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.53142082854758 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.52938239070386 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.52887308780164 bayes_pls_golite062009
  • nucleotide binding
    		•  1.52746968836881 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.47858140861683 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.35938517416356 bayes_pls_golite062009
  • ATP binding
    		•  1.23942044024113 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.21044170258803 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.20315703345493 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.19481945569892 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • kinase activity
    		•  1.11120928120082 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.05408274676326 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.908046791062776 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • structural molecule activity
    		•  0.86514677273731 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.8469248456592 bayes_pls_golite062009
  • motor activity
    		•  0.61636596887462 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.421921195209539 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.406600732518248 bayes_pls_golite062009
  • protein kinase activity
    		•  0.351308564667977 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • transferase activity
    		•  0.175269600441384 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.156278588350022 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13366911641814 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0272673919333979 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0223627159838333 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle