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Protein Overview: mcl1

General Information:
Name(s) found: mcl1 / SPAPB1E7.02c [Sanger Pombe]
Description(s) found:
Found 16 descriptions.
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  • DNA polymerase alpha accessory factor Mcl1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 815 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    alpha DNA polymerase:primase complex [IDALink to PubMed article]
    nuclear chromosome [ISSLink to PubMed article]
    Biological Process: sister chromatid cohesion [TASLink to PubMed article]
    G1/S transition of mitotic cell cycle [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    regulation of DNA replication [TASLink to PubMed article]
    response to DNA damage stimulus [IGILink to PubMed article]
    DNA replication, removal of RNA primer [IGILink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    chromatin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNRLVPRY AHTDGLTRLA YTRDGKFLLT VGSNQVIRKF QVGSDEEPDS IDNHQDPITG  60
   61 IAVAENYFCT CSEDATVCVY PIDSPTEHTL LARTTLPIRD VAYSVDGNWI AIASDETAVK 120
  121 VVSSTDSSQI FSLRPAKASN KHVTYSPNGN FLAVSSCNGI LYFYDTQTRE LIKFLTNTIA 180
  181 SLEAESEICS KAAWHPKNGT FAVASTDHFV SVISPDDWLP LYKLLPKENH SGVTDISWSS 240
  241 NGMYIAASFK KGGILIWDTQ SHEVVVELPY STVVALAWQP FENVLSFTTN QGILYSCPDV 300
  301 IPKSILKEEN DPTKPLTSSK SKNRTSKELD DLFGSDDEQS QNVNDLDGNS ANEENEFINH 360
  361 DGLDSSLDLD GDSYMVDEND LNLAKKRKQK ALIDRTTTIE NGSSKRRLLQ ASIHKPVHTG 420
  421 STPWQGNRRY LCLNLVGFIW TVQQDAEHNT ITVEFHDETT HRKYHFVDDQ KFEMACLDHE 480
  481 GALYASPATE SSPGVIYYKA HVDWSRKSEW AMALPMENES PVTISLSSSV VLVCTSAGYV 540
  541 RVFSRQGFPI SIHRSKHLPF VACSSFQDTI ITIANDGLSS DGNSRLVYSI EDISRDEMLQ 600
  601 TGDGVALPPQ GTLESVFFSD VGDPYIYDST GVLLVLMHWR IPGQAKWIPV LDTNELERRK 660
  661 SRQESYWPVT VADNQFHCIL LKGASRYPYF PRPMFTEFDF RIPCNTNNPD ASTSVPVLEE 720
  721 LQLRNKLFLT LLEDSIGDGD VTEDEKISIA RLEANIDKAL LQLIQKACLE ERIERVYELT 780
  781 KTLRRTTSIA AAQKIALHHS LTNVAEKIGN LLSNV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] PSI-BLAST 83.39794 No description for 2gnqA was found.
    2 View Details [74..639] PSI-BLAST 54.522879 Actin interacting protein 1
    3 View Details [640..815] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10348788067437 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.00420268007946 bayes_pls_golite062009
  • DNA binding
    		•  1.53482914288832 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • transcription factor activity
    		•  0.897833210520351 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.624053529462119 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.57463592694759 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • telomerase activity
    		•  0.51194134550542 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.48357253721614 bayes_pls_golite062009
  • transcription factor binding
    		•  0.469377587704245 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.428715007921149 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.245000508226811 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • RNA-directed DNA polymerase activity
    		•  0.18203222513175 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0936365746095786 bayes_pls_golite062009
  • RNA binding
    		•  0.0914092269020899 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0676565515282608 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle