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View Structure Prediction Details

Protein: mcl1
Organism: Schizosaccharomyces pombe
Length: 815 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mcl1.

Description E-value Query
Range
Subject
Range
gi|186464325, gi... - gi|23128981|ref|ZP_00110817.1| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi|18668187...
632.0 [0..6] [664..1165]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
616.0 [0..2] [661..895]
gi|148658115, gi... - gi|148658115|ref|YP_001278320.1| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi|1485702...
613.0 [0..2] [680..768]
gi|75701503, gi|... - gi|75907778|ref|YP_322074.1| ribosome assembly protein 4 (RSA4) [Anabaena variabilis ATCC 29413], gi...
598.0 [0..4] [658..1035]
gi|115443476, gi... - gi|115443476|ref|XP_001218545.1| hypothetical protein ATEG_09923 [Aspergillus terreus NIH2624], gi|1...
575.0 [0..6] [627..641]
gi|110168368, gi... - gi|71673858|ref|ZP_00671606.1| G-protein beta WD-40 repeat [Trichodesmium erythraeum IMS101], gi|716...
572.0 [0..6] [697..838]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGNRLVPRY AHTDGLTRLA YTRDGKFLLT VGSNQVIRKF QVGSDEEPDS IDNHQDPITG  60
   61 IAVAENYFCT CSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 83.39794
Match: 2gnqA
Description: No description for 2gnqA was found.

Predicted Domain #2
Region A:
Residues: [74-639]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DATVCVYPID SPTEHTLLAR TTLPIRDVAY SVDGNWIAIA SDETAVKVVS STDSSQIFSL  60
   61 RPAKASNKHV TYSPNGNFLA VSSCNGILYF YDTQTRELIK FLTNTIASLE AESEICSKAA 120
  121 WHPKNGTFAV ASTDHFVSVI SPDDWLPLYK LLPKENHSGV TDISWSSNGM YIAASFKKGG 180
  181 ILIWDTQSHE VVVELPYSTV VALAWQPFEN VLSFTTNQGI LYSCPDVIPK SILKEENDPT 240
  241 KPLTSSKSKN RTSKELDDLF GSDDEQSQNV NDLDGNSANE ENEFINHDGL DSSLDLDGDS 300
  301 YMVDENDLNL AKKRKQKALI DRTTTIENGS SKRRLLQASI HKPVHTGSTP WQGNRRYLCL 360
  361 NLVGFIWTVQ QDAEHNTITV EFHDETTHRK YHFVDDQKFE MACLDHEGAL YASPATESSP 420
  421 GVIYYKAHVD WSRKSEWAMA LPMENESPVT ISLSSSVVLV CTSAGYVRVF SRQGFPISIH 480
  481 RSKHLPFVAC SSFQDTIITI ANDGLSSDGN SRLVYSIEDI SRDEMLQTGD GVALPPQGTL 540
  541 ESVFFSDVGD PYIYDSTGVL LVLMHW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.522879
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.10348788067437 bayes_pls_golite062009
nucleic acid binding 2.00420268007946 bayes_pls_golite062009
DNA binding 1.53482914288832 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 0.897833210520351 bayes_pls_golite062009
0.88172763425403 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
transcription repressor activity 0.624053529462119 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.57463592694759 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
telomerase activity 0.51194134550542 bayes_pls_golite062009
small conjugating protein ligase activity 0.48357253721614 bayes_pls_golite062009
transcription factor binding 0.469377587704245 bayes_pls_golite062009
DNA polymerase activity 0.428715007921149 bayes_pls_golite062009
transcription cofactor activity 0.245000508226811 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
RNA-directed DNA polymerase activity 0.18203222513175 bayes_pls_golite062009
hydrolase activity 0.181211933860468 bayes_pls_golite062009
histone binding 0.166694897714113 bayes_pls_golite062009
structural molecule activity 0.0936365746095786 bayes_pls_golite062009
RNA binding 0.0914092269020899 bayes_pls_golite062009
transcription corepressor activity 0.0676565515282608 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [640-815]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIPGQAKWIP VLDTNELERR KSRQESYWPV TVADNQFHCI LLKGASRYPY FPRPMFTEFD  60
   61 FRIPCNTNNP DASTSVPVLE ELQLRNKLFL TLLEDSIGDG DVTEDEKISI ARLEANIDKA 120
  121 LLQLIQKACL EERIERVYEL TKTLRRTTSI AAAQKIALHH SLTNVAEKIG NLLSNV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle