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Protein Overview: dld1

General Information:
Name(s) found: dld1 / SPAC1002.09c [Sanger Pombe]
Description(s) found:
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  • gi|6689266|emb|CAB65609.1| dihydrolipoamide dehydrogenase Dld1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114408|ref|NP_593496.1| dihydrolipoamide dehydrogenase Dld1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|13124714|sp|O00087.2|DLDH_SCHPO RecName: Full=Dihydrolipoyl dehydrogenase, mitochondrial; AltName: Full=Dihydrolipoamide dehydrogenase; Short=DLDH; Flags: Precursor [NCBI NR]
  • dihydrolipoamide dehydrogenase Dld1 [Sanger Pombe]
  • Dihydrolipoyl dehydrogenase, mitochondrial OS=Schizosaccharomyces pombe GN=dld1 PE=2 SV=2 [Swiss-Prot]
  • DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL ; SIMILAR TO S. CEREVISIAE LPD1: O00087;Q9US50; [pompepVF.fasta]
  • DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.8.1.4): O00087;Q9US50; [pompepV13]
  • Dihydrolipoamide dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (DLDH) [pompep4896]
  • |dld1|dldh|dihydrolipoamide dehydrogenase [pompepnew.fasta]
  • Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (DLDH) (Dihydrolipoamide dehydrogenase) [4896.FASTAC]
  • |dld1|dldh|dihydrolipoamide dehydrogenase (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • dihydrolipoamide dehydrogenase (predicted) [Schizosaccharomyces pombe]gi|19114408|ref|NP_593496.1| dihydrolipoamide dehydrogenase, mitochondrial precursor (EC 1.8.1.4) [Schizosaccharomyces pombe]gi|13124714|sp|O00087|DLDH_SCHPO Dihydrolipoyl dehydrogena [nrdb_11152004_Chlamydomonas]
  • |dld1|dldh|dihydrolipoamide dehydrogenase|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (O00087) Dihydrolipoamide dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (DLDH) [pompep4896_normal_reversed]
  • |dld1|dldh|dihydrolipoamide dehydrogenase Dld1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Dihydrolipoyl dehydrogenase, mitochondrial precursor (DLDH) (Dihydrolipoamide dehydrogenase) [nr-271106-contam.fasta]
  • SPAC1002.09c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC1002.09c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Dihydrolipoyl dehydrogenase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dld1 PE=2 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial pyruvate dehydrogenase complex [ISSLink to PubMed article]
    mitochondrial oxoglutarate dehydrogenase complex [ICLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    glycine cleavage complex [ISSLink to PubMed article]
    mitochondrial nucleoid [ISSLink to PubMed article]
    Biological Process: acetyl-CoA biosynthetic process from pyruvate [ISSLink to PubMed article]
    leucine catabolic process [ISSLink to PubMed article]
    valine catabolic process [ISSLink to PubMed article]
    L-serine biosynthetic process [ISSLink to PubMed article]
    glycine decarboxylation via glycine cleavage system [ISSLink to PubMed article]
    isoleucine catabolic process [ISSLink to PubMed article]
    2-oxoglutarate metabolic process [ICLink to PubMed article]
    Molecular Function: disulfide oxidoreductase activity [ISSLink to PubMed article]
    FAD binding [IEA]
    oxoglutarate dehydrogenase (succinyl-transferring) activity [ISSLink to PubMed article]
    pyruvate dehydrogenase (acetyl-transferring) activity [ISSLink to PubMed article]
    glycine dehydrogenase (decarboxylating) activity [ISSLink to PubMed article]
    dihydrolipoyl dehydrogenase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNSVIKRSA LCRFKFTCLQ VSECRPAQIE ISKRLYSAKA SGNGEYDLCV IGGGPGGYVA  60
   61 AIRGAQLGLK TICVEKRGTL GGTCLNVGCI PSKALLNNSH IYHTVKHDTK RRGIDVSGVS 120
  121 VNLSQMMKAK DDSVKSLTSG IEYLFKKNKV EYAKGTGSFI DPQTLSVKGI DGAADQTIKA 180
  181 KNFIIATGSE VKPFPGVTID EKKIVSSTGA LSLSEVPKKM TVLGGGIIGL EMGSVWSRLG 240
  241 AEVTVVEFLP AVGGPMDADI SKALSRIISK QGIKFKTSTK LLSAKVNGDS VEVEIENMKN 300
  301 NKRETYQTDV LLVAIGRVPY TEGLGLDKLG ISMDKSNRVI MDSEYRTNIP HIRVIGDATL 360
  361 GPMLAHKAED EGIAAVEYIA KGQGHVNYNC IPAVMYTHPE VAWVGITEQK AKESGIKYRI 420
  421 GTFPFSANSR AKTNMDADGL VKVIVDAETD RLLGVHMIGP MAGELIGEAT LALEYGASAE 480
  481 DVARVCHAHP TLSEATKEAM MAAWCGKSIH F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..511] PSI-BLAST 102.0 Dihydrolipoamide dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  8.42473605174108 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  8.07008457237017 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  7.86778387378753 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  7.84550673347799 bayes_pls_golite062009
  • lipoamide binding
    		•  7.21320397413054 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  6.68894387221662 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.56425883527182 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  6.2758493127081 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  6.2758493127081 bayes_pls_golite062009
  • oxoglutarate dehydrogenase (succinyl-transferring) activity
    		•  5.32373368820399 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  4.48151296542899 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.19923051777224 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.05603184984386 bayes_pls_golite062009
  • antioxidant activity
    		•  3.99666840824738 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.78622758776028 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  3.68406278988218 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.50748163367583 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  3.23754178295825 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
    		•  3.15456908604913 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  3.04300775355641 bayes_pls_golite062009
  • glutathione binding
    		•  2.84679371365652 bayes_pls_golite062009
  • glutathione-disulfide reductase activity
    		•  2.72350669229836 bayes_pls_golite062009
  • oxidoreductase activity, oxidizing metal ions
    		•  2.49798084628282 bayes_pls_golite062009
  • tubulin binding
    		•  2.40546880499445 bayes_pls_golite062009
  • catalytic activity
    		•  2.35839632763616 bayes_pls_golite062009
  • microtubule binding
    		•  2.30064869971937 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.23446140524739 bayes_pls_golite062009
  • peptide disulfide oxidoreductase activity
    		•  2.13269617402519 bayes_pls_golite062009
  • glutathione disulfide oxidoreductase activity
    		•  2.13269617402519 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.87417564758524 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  1.71836807554864 bayes_pls_golite062009
  • binding
    		•  1.50672625307126 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.42994468012845 bayes_pls_golite062009
  • protein binding
    		•  1.21627488765992 bayes_pls_golite062009
  • transporter activity
    		•  1.16027171869703 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.04563737396213 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.992020263296138 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.886337714694097 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.795364404071999 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.718226588475577 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • transferase activity
    		•  0.649374189439191 bayes_pls_golite062009
  • electron carrier activity
    		•  0.511623955786613 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
  • coenzyme binding
    		•  0.10945648874523 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle