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Protein Overview: dis3

General Information:
Name(s) found: dis3 / SPBC26H8.10 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • 3'-5' exoribonuclease subunit Dis3 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 970 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic exosome (RNase complex) [ISSLink to PubMed article]
    nuclear exosome (RNase complex) [ISSLink to PubMed article]
    nucleus [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [ISSLink to PubMed article]
    Biological Process: mitotic sister chromatid segregation [IMPLink to PubMed article]
    mRNA catabolic process [ISSLink to PubMed article]
    regulation of growth [IEA]
    regulation of mitotic cell cycle [IMPLink to PubMed article]
    exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISS]
    positive regulation of Ran GTPase activity [IMPLink to PubMed article]
    Molecular Function: 3'-5'-exoribonuclease activity [ISSLink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    RNA binding [IEA]
    Ran GTPase binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVSGLKRP QSSEKNHRDR VFVRATRGKV QKVVREQYLR NDIPCQSRAC PLCRSKLPKD  60
   61 SRGNVLEPIL SEKPMFLEKF GHHYLIPDSN IFYHCIDALE HPNNFFDVII LQTVFSEISS 120
  121 KSIPLYNRMK RLCQEKTKRF TPFSNEFFVD TFVERLDDES ANDRNDRAIR NAASWFASHL 180
  181 ASLGIKIVLL TDDRENARLA AEQGIQVSTL KDYVQYLPDS EILLDMVSAI ADAIASKEQV 240
  241 ESGTKNVYEL HWSMSRLLAC IKNGEVHKGL INISTYNYLE GSVVVPGYNK PVLVSGRENL 300
  301 NRAVQGDIVC IQILPQDQWK TEAEEIADDD EDVVVSTAAE PDSARINDLE LITKRNAHPT 360
  361 AKVVGILKRN WRPYVGHVDN ATIAQSKGGS QQTVLLTPMD RRVPKIRFRT RQAPRLVGRR 420
  421 IVVAIDLWDA SSRYPEGHFV RDLGEMETKE AETEALLLEY DVQHRPFPKA VLDCLPEEGH 480
  481 NWKVPADKTH PLWKNRKDFR DKLICSIDPP GCQDIDDALH ACVLPNGNYE VGVHIADVTH 540
  541 FVKPNTSMDS EAASRGTTVY LVDKRIDMLP MLLGTDLCSL RPYVERFAFS CIWEMDENAN 600
  601 IIKVHFTKSV IASKEAFSYA DAQARIDDQK MQDPLTQGMR VLLKLSKILK QKRMDEGALN 660
  661 LASPEVRIQT DNETSDPMDV EIKQLLETNS LVEEFMLLAN ISVAQKIYDA FPQTAVLRRH 720
  721 AAPPLTNFDS LQDILRVCKG MHLKCDTSKS LAKSLDECVD PKEPYFNTLL RILTTRCMLS 780
  781 AEYFCSGTFA PPDFRHYGLA SPIYTHFTSP IRRYADVLAH RQLAAAIDYE TINPSLSDKS 840
  841 RLIEICNGIN YRHRMAQMAG RASIEYYVGQ ALKGGVAEED AYVIKVFKNG FVVFIARFGL 900
  901 EGIVYTKSLS SVLEPNVEYV EDEYKLNIEI RDQPKPQTVQ IQMFQQVRVR VTTVRDEHSG 960
  961 KQKVQITLVY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..288] FFAS03 4.81 No description for 2dokA was found.
    2 View Details [289..970] PSI-BLAST 138.0 No description for 2ix0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ribonuclease activity
    		•  7.42330864261751 bayes_pls_golite062009
  • exoribonuclease activity
    		•  6.76241588209982 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  6.73428326869965 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  5.13367897180134 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  3.51306349336452 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.194200758646 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  3.07263153665399 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.73968547121328 bayes_pls_golite062009
  • DNA binding
    		•  2.71213098011194 bayes_pls_golite062009
  • exonuclease activity
    		•  2.66053639652924 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  2.04350689362549 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  2.04350689362549 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  2.04218282227834 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.02605441840546 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • structural molecule activity
    		•  1.81283970647925 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • exoribonuclease II activity
    		•  1.18248519339188 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.15591101342538 bayes_pls_golite062009
  • ligase activity
    		•  1.06979791212194 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.996884322431837 bayes_pls_golite062009
  • hydrolase activity
    		•  0.724860465280978 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.586976595520399 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.504302440847948 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • translation regulator activity
    		•  0.22908707234671 bayes_pls_golite062009
  • chromatin binding
    		•  0.1876135725713 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.179682348023561 bayes_pls_golite062009
  • protein binding
    		•  0.152645195799531 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.11625379846973 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle