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View Structure Prediction Details

Protein: dis3
Organism: Schizosaccharomyces pombe
Length: 970 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dis3.

Description E-value Query
Range
Subject
Range
gi|109501948 - gi|109501948|ref|XP_224449.4| PREDICTED: similar to KIAA1008 [Rattus norvegicus]
1026.0 [0..2] [969..55]
gi|145018949, gi... - gi|39975321|ref|XP_369051.1| hypothetical protein MGG_00193 [Magnaporthe grisea 70-15], gb|EAA48535....
1021.0 [0..4] [969..1]
gi|85111130 - gi|85111130|ref|XP_963787.1| mitotic control protein dis3 [Neurospora crassa OR74A]
gi|32420115, gi|... - gi|32420115|ref|XP_330501.1| hypothetical protein [Neurospora crassa], gi|28925520|gb|EAA34551.1| mi...
1019.0 [0..6] [969..32]
gi|19923416, gi|... - gi|19923416|ref|NP_055768.2| KIAA1008 [Homo sapiens], gi|189054486|dbj|BAG37259.1| unnamed protein p...
1001.0 [0..16] [969..1]
gi|114650043 - gi|114650043|ref|XP_509678.2| PREDICTED: KIAA1008 [Pan troglodytes]
1000.0 [0..16] [969..1]
gi|42545807, gi|... - gi|46108604|ref|XP_381360.1| hypothetical protein FG01184.1 [Gibberella zeae PH-1], gi|42545807|gb|E...
998.0 [0..4] [969..1]

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Predicted Domain #1
Region A:
Residues: [1-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVSGLKRP QSSEKNHRDR VFVRATRGKV QKVVREQYLR NDIPCQSRAC PLCRSKLPKD  60
   61 SRGNVLEPIL SEKPMFLEKF GHHYLIPDSN IFYHCIDALE HPNNFFDVII LQTVFSEISS 120
  121 KSIPLYNRMK RLCQEKTKRF TPFSNEFFVD TFVERLDDES ANDRNDRAIR NAASWFASHL 180
  181 ASLGIKIVLL TDDRENARLA AEQGIQVSTL KDYVQYLPDS EILLDMVSAI ADAIASKEQV 240
  241 ESGTKNVYEL HWSMSRLLAC IKNGEVHKGL INISTYNYLE GSVVVPGY

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.81
Match: 2dokA
Description: No description for 2dokA was found.

Predicted Domain #2
Region A:
Residues: [289-970]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPVLVSGRE NLNRAVQGDI VCIQILPQDQ WKTEAEEIAD DDEDVVVSTA AEPDSARIND  60
   61 LELITKRNAH PTAKVVGILK RNWRPYVGHV DNATIAQSKG GSQQTVLLTP MDRRVPKIRF 120
  121 RTRQAPRLVG RRIVVAIDLW DASSRYPEGH FVRDLGEMET KEAETEALLL EYDVQHRPFP 180
  181 KAVLDCLPEE GHNWKVPADK THPLWKNRKD FRDKLICSID PPGCQDIDDA LHACVLPNGN 240
  241 YEVGVHIADV THFVKPNTSM DSEAASRGTT VYLVDKRIDM LPMLLGTDLC SLRPYVERFA 300
  301 FSCIWEMDEN ANIIKVHFTK SVIASKEAFS YADAQARIDD QKMQDPLTQG MRVLLKLSKI 360
  361 LKQKRMDEGA LNLASPEVRI QTDNETSDPM DVEIKQLLET NSLVEEFMLL ANISVAQKIY 420
  421 DAFPQTAVLR RHAAPPLTNF DSLQDILRVC KGMHLKCDTS KSLAKSLDEC VDPKEPYFNT 480
  481 LLRILTTRCM LSAEYFCSGT FAPPDFRHYG LASPIYTHFT SPIRRYADVL AHRQLAAAID 540
  541 YETINPSLSD KSRLIEICNG INYRHRMAQM AGRASIEYYV GQALKGGVAE EDAYVIKVFK 600
  601 NGFVVFIARF GLEGIVYTKS LSSVLEPNVE YVEDEYKLNI EIRDQPKPQT VQIQMFQQVR 660
  661 VRVTTVRDEH SGKQKVQITL VY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 138.0
Match: 2ix0A
Description: No description for 2ix0A was found.

Predicted functions:

Term Confidence Notes
ribonuclease activity 7.42330864261751 bayes_pls_golite062009
exoribonuclease activity 6.76241588209982 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 6.73428326869965 bayes_pls_golite062009
3'-5'-exoribonuclease activity 5.13367897180134 bayes_pls_golite062009
3'-5' exonuclease activity 3.51306349336452 bayes_pls_golite062009
nucleic acid binding 3.194200758646 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3.07263153665399 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.73968547121328 bayes_pls_golite062009
DNA binding 2.71213098011194 bayes_pls_golite062009
exonuclease activity 2.66053639652924 bayes_pls_golite062009
RNA binding 2.41160981373213 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 2.04350689362549 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 2.04350689362549 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 2.04218282227834 bayes_pls_golite062009
structural constituent of ribosome 2.02605441840546 bayes_pls_golite062009
structure-specific DNA binding 1.81524862921454 bayes_pls_golite062009
structural molecule activity 1.81283970647925 bayes_pls_golite062009
single-stranded DNA binding 1.62996999055328 bayes_pls_golite062009
1.5765009871268 bayes_pls_golite062009
exoribonuclease II activity 1.18248519339188 bayes_pls_golite062009
telomeric DNA binding 1.15591101342538 bayes_pls_golite062009
ligase activity 1.06979791212194 bayes_pls_golite062009
transcription regulator activity 0.996884322431837 bayes_pls_golite062009
hydrolase activity 0.724860465280978 bayes_pls_golite062009
single-stranded telomeric DNA binding 0.586976595520399 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.504302440847948 bayes_pls_golite062009
mRNA binding 0.4162128308402 bayes_pls_golite062009
sequence-specific DNA binding 0.32084431704638 bayes_pls_golite062009
transcription factor activity 0.298729064067577 bayes_pls_golite062009
translation regulator activity 0.22908707234671 bayes_pls_golite062009
chromatin binding 0.1876135725713 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.179682348023561 bayes_pls_golite062009
protein binding 0.152645195799531 bayes_pls_golite062009
translation initiation factor activity 0.11625379846973 bayes_pls_golite062009
RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.0740938021136293 bayes_pls_golite062009

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