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Protein Overview: SPBC1271.04c

General Information:
Name(s) found: SPBC1271.04c [Sanger Pombe]
Description(s) found:
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  • gi|8928099|sp|O94337.2|DHYS_SCHPO RecName: Full=Probable deoxyhypusine synthase; Short=DHS [NCBI NR]
  • gi|6912225|emb|CAA22194.2| eIF-5A-deoxyhypusine synthase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19111938|ref|NP_595146.1| deoxyhypusine synthase [Schizosaccharomyces pombe] [NCBI NR]
  • deoxyhypusine synthase [Sanger Pombe]
  • Probable deoxyhypusine synthase OS=Schizosaccharomyces pombe GN=SPBC1271.04c PE=2 SV=2 [Swiss-Prot]
  • DEOXYHYPUSINE SYNTHASE: O94337; [pompepVF.fasta]
  • Probable deoxyhypusine synthase (EC 2.5.1.46) (DHS) [pompep4896]
  • |||deoxyhypusine synthase [pompepnew.fasta]
  • |||deoxyhypusine synthase|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • deoxyhypusine synthase [Schizosaccharomyces pombe]gi|6912225|emb|CAA22194.2| SPBC1271.04c [Schizosaccharomyces pombe]gi|8928099|sp|O94337|DHYS_SCHPO Probable deoxyhypusine synthase (DHS) [nrdb_11152004_Chlamydomonas]
  • (O94337) Probable deoxyhypusine synthase (EC 2.5.1.46) (DHS) [pompep4896_normal_reversed]
  • |||eIF-5A-deoxyhypusine synthase|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Probable deoxyhypusine synthase (DHS) [nr-271106-contam.fasta]
  • deoxyhypusine synthase [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC1271.04c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • |||eIF-5A-deoxyhypusine synthase |Schizosaccharomyces pombe|chr 2|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Probable deoxyhypusine synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1271.04c PE=3 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase [ICLink to PubMed article]
    regulation of translational elongation [IC]
    peptidyl-lysine modification to hypusine [ISSLink to PubMed article]
    Molecular Function: deoxyhypusine synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDESLAKDAV FVASSKPSDL TTEVVGPDFN KYDERKKAGG PGITVEELVE SYGKIGFQAT  60
   61 NLHDAVTIIN EMRNWRDPNP PEEKSDRATI FLGYTSNLIS SGVREVLRYL VQHKCVDVIV 120
  121 TTAGGVEEDI IKCLGPTYVG DFHLDGKNLR AKGLNRIGNL IVPNDNYCRF EEWIFPILNK 180
  181 MVEEQETLGT HWTPSSFIRR LGKEINDESS VLYWAYKNNI PIYSPALTDG SIGDMLYFHT 240
  241 YKATPRPLVL DIVADIRNMN THAVRANKSG IIILGGGVVK HHICNANLMR NGAEWSVYIN 300
  301 SANEFDGSDA GARPDEAVSW GKIRGDAKKV KVYGEVSLLF PLIVAATFAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] PSI-BLAST 153.0 CRYSTAL STRUCTURE OF THE NAD COMPLEX OF HUMAN DEOXYHYPUSINE SYNTHASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • deoxyhypusine synthase activity
    		•  4.8590235726137 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.51117258094456 bayes_pls_golite062009
  • protein deacetylase activity
    		•  2.11398191156761 bayes_pls_golite062009
  • DNA binding
    		•  2.09930834951157 bayes_pls_golite062009
  • histone deacetylase activity
    		•  2.08718650273166 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.00972611627502 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • protein binding
    		•  1.52593340148652 bayes_pls_golite062009
  • deacetylase activity
    		•  1.15111805612466 bayes_pls_golite062009
  • transcription factor binding
    		•  1.07103864164531 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0180828203704 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.516307124442946 bayes_pls_golite062009
  • transferase activity
    		•  0.483523935618287 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.42635585193838 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.23414654967509 bayes_pls_golite062009
  • hydrolase activity
    		•  0.169696911903799 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle