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The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+. The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase
Acc: GO:0050983
Aspect: Biological Process
Desc: The chemical reactions resulting in the breakdown of spermidine to form deoxyhypusine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+.
Synonyms:
  • (4-aminobutyl)lysine synthase activity
  • spermidine breakdown to deoxyhypusine, using deoxyhypusine synthase
  • spermidine degradation to deoxyhypusine, using deoxyhypusine synthase
  • [eIF-5A]-deoxyhypusine synthase activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0050983 - spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle