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Protein Overview: rut-PA

General Information:
Name(s) found: rut-PA / FBpp0073809 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene rutabaga is referred to in FlyBase by the symbol Dmel\rut (CG9533, FBgn0003301). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14683284..14719938. It has the cytological map location 12F4. It is reported to have molecular function</span>: adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: learning or memory; system process; synaptic transmission; memory; response to chemical stimulus; response to stress; cell-cell signaling; molting cycle, chitin-based cuticle; associative learning; determination of adult lifespan; anatomical structure development. 32 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: nervous system; organ system; anatomical structure; embryonic neuron; multi-cell-component structure; peripheral nervous system; embryonic nervous system; organism; adult brain; synapse; neuromuscular junction. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2248 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    membrane [IDA]
    integral to membrane [IEA]
    Biological Process: cAMP biosynthetic process [NAS][TAS]
    G-protein coupled receptor protein signaling pathway [TAS]
    neuromuscular synaptic transmission [IMP]
    molting cycle, chitin-based cuticle [IGI]
    determination of adult lifespan [IMP]
    synaptic transmission [IMP]
    olfactory learning [NAS][TAS]
    behavioral response to ethanol [IMP][NAS][TAS]
    learning [NAS]
    memory [IMP]
    conditioned taste aversion [IMP]
    learning or memory [IDA][IMP][NAS][TAS]
    mating behavior [TAS]
    response to oxidative stress [IMP]
    grooming behavior [NAS]
    response to heat [IMP]
    short-term memory [IMP]
    intracellular signaling pathway [IEA]
    axon extension [IMP]
    courtship behavior [TAS]
    cyclic nucleotide biosynthetic process [IDA]
    cAMP-mediated signaling [NAS]
    Molecular Function: calcium- and calmodulin-responsive adenylate cyclase activity [IDA][IMP][NAS][TAS]
    adenylate cyclase activity [NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHAVKATRG RPLNTLRFEN DELECLYQRY TLKLQRFSVL GVVALVFVLC GVMAALSLTF  60
   61 NNAATFHNIF NAIVCGLFAV VLVLLQCSVI KDHHLPTLCY GILLFTASIC VVSMPTLGSV 120
  121 FPVDTKEVMA EGVWQIVFVV FLAYAMMPLQ IWEAVAFGIA LPSVHISLTV YKIFTDALRY 180
  181 LEYNQLIANI VIFIGVNVAG LVVNIMMERA QRRTFLDTRN CIASRLEIQD ENEKLERLLL 240
  241 SVLPQHVAMQ MKNDILSPVA GQFHRIYIQK HENVSILFAD IVGFTVLSSQ CSAQELVRLL 300
  301 NELFGRFDQL AHDNHCLRIK ILGDCYYCVS GLPEPRKDHA KCAVEMGLDM IDAIATVVEA 360
  361 TDVILNMRVG IHTGRVLCGV LGLRKWQFDV WSNDVTLANH MESGGEPGRV HVTRATLDSL 420
  421 SGEYEVEAGH GDERSSYLRD HGVDTFFIVP PPHRRKPLML NTLGVRSAIG SRRKLSFRNV 480
  481 SNVVMQLLHT IKFSEPVPFS NIATGSFPSA ASALGGGVSV GGGGGGGGGG VARGSTCEAN 540
  541 SGNVQVSEKG SRKVIRLQKI LHATPPPHGM GYGSVVGSGG GVDSGISGGG GCVSGGIAGG 600
  601 GGVQVTVGTN PNSTASTISR IHRHNHKNNK SQSKVADKFK RPFRKRHSVA AHHQPTNRVN 660
  661 RFLSQAINAR SVDCDKSEHV DRLTLRFRQS DMEREYHKDF DLGFTTAMGC SLLLLILGAA 720
  721 LQVTALPRTL ILLLLFLFAF IWVSAILMLL LAVRLKWIIW DISESFSLRM AITIFTVILI 780
  781 YSVGQVNVFT CVSDHPCSGN GTTSFQNDSH RKCSLPQYVS LSAAFAFLSV SVFLRLPIIF 840
  841 KSLLVLGMGT IYGLFIELSH QNIFECYDNR VNASIPLHLI SLARIAIFMI AILVHGRLVE 900
  901 GTARLDFLWQ LQASQEKKEM DVLQESNKRI LHNLLPAHVA AHFLDAQFRN NMELYHQSYA 960
  961 KVGVIFASVP NFNEFYTEMD GSDQGLECLR LLNEIIADFD ELLKEDRFRG IDKIKTVGST1020
 1021 YMAVVGLIPE YKIQPNDPNS VRRHMTALIE YVKAMRHSLQ EINSHSYNNF MLRVGINIGP1080
 1081 VVAGVIGARK PQYDIWGNTV NVASRMDSTG VPGYSQVTQE VVDSLVGSHF EFRCRGTIKV1140
 1141 KGKGDMVTYF LCDSGNKSLN GEVRNAMSLP QSLHAPDYYM KVSQFPENRV NTDTYSKKEN1200
 1201 GHLYAGNGVE EQQLLLQHQH KQHDPLPLPA PPPPVHHHLH QQQQQRLNSK LQKQPIFMAN1260
 1261 GGLPNIRENG NGHNGEHQQQ QQQQQQHQQQ QQQQQQHGGF MVATTTPPAA VAVPLQPQHH1320
 1321 QLQFQHPHQH PLPSAVSVPV QHQILLHHQL QLQHQPVPSV MLREFNIIEN PTSGGRHQQM1380
 1381 EQLPPHHGSL DLSGMGMGVG AGVLGSDCFM MPRRDRERTY VPPLNQHGHH PPHHLHSNLN1440
 1441 LNQSQHPPSF TSLGYGQCRE SEPLLHASSV APVAKIMPMQ HAPKYEPPRY TSPHTMLSQQ1500
 1501 HQQQQQQQHQ HQQPQSQSAQ DQQTHPAQDP HPLQRQYAMY SQQPQLPPKP VLRTYMKPLP1560
 1561 KLPTDLEESR DMSSTDDLSS RPHSPSMSSS DESYSKTTEG EGEGDEDSPR MVNGGHLHHR1620
 1621 NGYHLPAGGL VNPLQWLYPC DIQVDPTSPV VDMAHLHDFE LSSTTESQGH HTNSNTTSNT1680
 1681 QHKGDSCNSF DFQKAAVGTA AGAAIATKSP FERELQRLLN ESSRARCLAT ATTTAGAIST1740
 1741 TDQTASNGSR ELSYSLSNGK LSSANGHGVG GSGSGSGSGS GSGSAVGNGS GGSGSSNGNL1800
 1801 SGGSGSNSNS GNNNSSHHKT EQQQNMDHEH LAGGKLLGSN SFMIAKHPVG LEAIKEITRN1860
 1861 KNPSESSQMQ TSDTESCEIL HENRNQMHVL AMLEMHTAKE LNGSHAHHGQ HHQQPQRTHR1920
 1921 QRPRSKELQY SHESLDGLDG AVQSQSQQRH QRYHHHHHHQ QRQQQQQRYN HVQEQEERDD1980
 1981 TEDNLADEEF EDDEVGRDVR QKRLQKSELN HKRSEVATEA GNHHDDEVEE EDDDDDEEED2040
 2041 HRNGGREAAP LTNGSMRGLE ANVINDELKY GATHLNHQSM DSNPLESQSE WSDDDCREEA2100
 2101 TGGAESTGYI TDEPGLENIS LLNEAGLTDA EGALSDVNSL YNAPDVDDTS VSSRASSRLL2160
 2161 SLDSLSGLYD CDLDSKHELA IVNASHKISS KFGQPLSPAQ QQHQQQQQQQ QQQQQQHHQQ2220
 2221 QLQQNPQHTQ AQSHLAPVQF QSAEELRE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] deduced N/A No confident structure predictions are available.
    2 View Details [200..512] PSI-BLAST 91.69897 Adenylyl cyclase VC1, domain C1a
    3 View Details [513..580] deduced N/A No confident structure predictions are available.
    4 View Details [581..652] deduced N/A No confident structure predictions are available.
    5 View Details [653..812] deduced N/A No confident structure predictions are available.
    6 View Details [813..937] deduced N/A No confident structure predictions are available.
    7 View Details [938..1160] PSI-BLAST 71.69897 Adenylyl cyclase IIC1, domain C2a
    8 View Details [1161..1223] deduced N/A No confident structure predictions are available.
    9 View Details [1224..1276] deduced N/A No confident structure predictions are available.
    10 View Details [1277..1389] deduced N/A No confident structure predictions are available.
    11 View Details [1390..1492] deduced N/A No confident structure predictions are available.
    12 View Details [1493..1669] PSI-BLAST 5.30103 Sec24
    13 View Details [1670..1861] deduced N/A No confident structure predictions are available.
    14 View Details [1862..2248] PSI-BLAST 26.69897 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • cyclase activity
    		•  4.79464954472979 bayes_pls_golite062009
  • phosphorus-oxygen lyase activity
    		•  4.43118857581325 bayes_pls_golite062009
  • adenylate cyclase activity
    		•  4.05704171095708 bayes_pls_golite062009
  • signal transducer activity
    		•  3.9121060122044 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.9121060122044 bayes_pls_golite062009
  • guanylate cyclase activity
    		•  2.73506223488482 bayes_pls_golite062009
  • receptor activity
    		•  1.96870434233851 bayes_pls_golite062009
  • binding
    		•  0.407021407526425 bayes_pls_golite062009
  • receptor binding
    		•  0.109024086594644 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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