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View Structure Prediction Details

Protein: rut-PA
Organism: Drosophila melanogaster
Length: 2248 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rut-PA.

Description E-value Query
Range
Subject
Range
gi|283638, gi|15... - sp|P32870|CYA1_DROME Ca(2+)/calmodulin-responsive adenylate cyclase (ATP pyrophosphate-lyase) (Rutab...
1339.0 [0..1] [2248..1]

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Predicted Domain #1
Region A:
Residues: [1-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHAVKATRG RPLNTLRFEN DELECLYQRY TLKLQRFSVL GVVALVFVLC GVMAALSLTF  60
   61 NNAATFHNIF NAIVCGLFAV VLVLLQCSVI KDHHLPTLCY GILLFTASIC VVSMPTLGSV 120
  121 FPVDTKEVMA EGVWQIVFVV FLAYAMMPLQ IWEAVAFGIA LPSVHISLTV YKIFTDALRY 180
  181 LEYNQLIANI VIFIGVNVA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [200-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLVVNIMMER AQRRTFLDTR NCIASRLEIQ DENEKLERLL LSVLPQHVAM QMKNDILSPV  60
   61 AGQFHRIYIQ KHENVSILFA DIVGFTVLSS QCSAQELVRL LNELFGRFDQ LAHDNHCLRI 120
  121 KILGDCYYCV SGLPEPRKDH AKCAVEMGLD MIDAIATVVE ATDVILNMRV GIHTGRVLCG 180
  181 VLGLRKWQFD VWSNDVTLAN HMESGGEPGR VHVTRATLDS LSGEYEVEAG HGDERSSYLR 240
  241 DHGVDTFFIV PPPHRRKPLM LNTLGVRSAI GSRRKLSFRN VSNVVMQLLH TIKFSEPVPF 300
  301 SNIATGSFPS AAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.69897
Match: 1cs4A
Description: Adenylyl cyclase VC1, domain C1a
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [513-580]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALGGGVSVGG GGGGGGGGVA RGSTCEANSG NVQVSEKGSR KVIRLQKILH ATPPPHGMGY  60
   61 GSVVGSGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [581-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVDSGISGGG GCVSGGIAGG GGVQVTVGTN PNSTASTISR IHRHNHKNNK SQSKVADKFK  60
   61 RPFRKRHSVA AH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [653-812]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQPTNRVNRF LSQAINARSV DCDKSEHVDR LTLRFRQSDM EREYHKDFDL GFTTAMGCSL  60
   61 LLLILGAALQ VTALPRTLIL LLLFLFAFIW VSAILMLLLA VRLKWIIWDI SESFSLRMAI 120
  121 TIFTVILIYS VGQVNVFTCV SDHPCSGNGT TSFQNDSHRK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [813-937]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSLPQYVSLS AAFAFLSVSV FLRLPIIFKS LLVLGMGTIY GLFIELSHQN IFECYDNRVN  60
   61 ASIPLHLISL ARIAIFMIAI LVHGRLVEGT ARLDFLWQLQ ASQEKKEMDV LQESNKRILH 120
  121 NLLPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [938-1160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVAAHFLDAQ FRNNMELYHQ SYAKVGVIFA SVPNFNEFYT EMDGSDQGLE CLRLLNEIIA  60
   61 DFDELLKEDR FRGIDKIKTV GSTYMAVVGL IPEYKIQPND PNSVRRHMTA LIEYVKAMRH 120
  121 SLQEINSHSY NNFMLRVGIN IGPVVAGVIG ARKPQYDIWG NTVNVASRMD STGVPGYSQV 180
  181 TQEVVDSLVG SHFEFRCRGT IKVKGKGDMV TYFLCDSGNK SLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 71.69897
Match: 1culB
Description: Adenylyl cyclase IIC1, domain C2a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclase activity 4.79464954472979 bayes_pls_golite062009
phosphorus-oxygen lyase activity 4.43118857581325 bayes_pls_golite062009
adenylate cyclase activity 4.05704171095708 bayes_pls_golite062009
signal transducer activity 3.9121060122044 bayes_pls_golite062009
molecular transducer activity 3.9121060122044 bayes_pls_golite062009
guanylate cyclase activity 2.73506223488482 bayes_pls_golite062009
receptor activity 1.96870434233851 bayes_pls_golite062009
binding 0.407021407526425 bayes_pls_golite062009
receptor binding 0.109024086594644 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1161-1223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVRNAMSLP QSLHAPDYYM KVSQFPENRV NTDTYSKKEN GHLYAGNGVE EQQLLLQHQH  60
   61 KQH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1224-1276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPLPLPAPPP PVHHHLHQQQ QQRLNSKLQK QPIFMANGGL PNIRENGNGH NGE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1277-1389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQQQQQQQQQ HQQQQQQQQQ HGGFMVATTT PPAAVAVPLQ PQHHQLQFQH PHQHPLPSAV  60
   61 SVPVQHQILL HHQLQLQHQP VPSVMLREFN IIENPTSGGR HQQMEQLPPH HGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1390-1492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLSGMGMGV GAGVLGSDCF MMPRRDRERT YVPPLNQHGH HPPHHLHSNL NLNQSQHPPS  60
   61 FTSLGYGQCR ESEPLLHASS VAPVAKIMPM QHAPKYEPPR YTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1493-1669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHTMLSQQHQ QQQQQQHQHQ QPQSQSAQDQ QTHPAQDPHP LQRQYAMYSQ QPQLPPKPVL  60
   61 RTYMKPLPKL PTDLEESRDM SSTDDLSSRP HSPSMSSSDE SYSKTTEGEG EGDEDSPRMV 120
  121 NGGHLHHRNG YHLPAGGLVN PLQWLYPCDI QVDPTSPVVD MAHLHDFELS STTESQG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #13
Region A:
Residues: [1670-1861]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHTNSNTTSN TQHKGDSCNS FDFQKAAVGT AAGAAIATKS PFERELQRLL NESSRARCLA  60
   61 TATTTAGAIS TTDQTASNGS RELSYSLSNG KLSSANGHGV GGSGSGSGSG SGSGSAVGNG 120
  121 SGGSGSSNGN LSGGSGSNSN SGNNNSSHHK TEQQQNMDHE HLAGGKLLGS NSFMIAKHPV 180
  181 GLEAIKEITR NK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1862-2248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSESSQMQT SDTESCEILH ENRNQMHVLA MLEMHTAKEL NGSHAHHGQH HQQPQRTHRQ  60
   61 RPRSKELQYS HESLDGLDGA VQSQSQQRHQ RYHHHHHHQQ RQQQQQRYNH VQEQEERDDT 120
  121 EDNLADEEFE DDEVGRDVRQ KRLQKSELNH KRSEVATEAG NHHDDEVEEE DDDDDEEEDH 180
  181 RNGGREAAPL TNGSMRGLEA NVINDELKYG ATHLNHQSMD SNPLESQSEW SDDDCREEAT 240
  241 GGAESTGYIT DEPGLENISL LNEAGLTDAE GALSDVNSLY NAPDVDDTSV SSRASSRLLS 300
  301 LDSLSGLYDC DLDSKHELAI VNASHKISSK FGQPLSPAQQ QHQQQQQQQQ QQQQQHHQQQ 360
  361 LQQNPQHTQA QSHLAPVQFQ SAEELRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

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