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Protein Overview: NetB-PD, NetB-PC...

General Information:
Name(s) found: FBpp0293415 [FlyBase]
FBpp0293414 [FlyBase]
NetB-PD / FBpp0291228 [FlyBase]
NetB-PC / FBpp0291227 [FlyBase]
NetB-PB / FBpp0291226 [FlyBase]
NetB-PA / FBpp0073757 [FlyBase]
Description(s) found:
Found 57 descriptions.
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  • type=protein; loc=X:complement(14585295..14585436,14585692..14585923,14586010..14586075,14586142..14586255,14586339..14586488,14587040..14587228,14640606..14642092,14642662..14642663); ID=FBpp0293415; name=NetB-PF; parent=FBgn0015774,FBtr0304875; dbxref=REFSEQ:NP_001245669,GB_protein:AFH07383,FlyBase:FBpp0293415,FlyBase_Annotation_IDs:CG10521-PF; MD5=2acaf17a7c713b0de53bb1e096181a6e; length=793; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:complement(14585295..14585436,14585692..14585923,14586010..14586075,14586142..14586255,14586339..14586488,14587040..14587228,14640606..14642092,14642662..14642663); ID=FBpp0293414; name=NetB-PE; parent=FBgn0015774,FBtr0304874; dbxref=REFSEQ:NP_001245668,GB_protein:AFH07382,FlyBase:FBpp0293414,FlyBase_Annotation_IDs:CG10521-PE; MD5=2acaf17a7c713b0de53bb1e096181a6e; length=793; release=r5.56; species=Dmel; [FlyBase]
  • The gene Netrin-B is referred to in FlyBase by the symbol Dmel\NetB (CG10521, FBgn0015774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14581645..14643407. It has the cytological map location 12F2-12F3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; dendrite guidance. 24 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: multi-cell-component structure; nervous system; peripheral nervous system; organ system; adult segment; abdominal segmental nerve; axon; commissure; embryonic nervous system; cell projection; adult mesothoracic segment; embryonic foregut. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Netrin-B is referred to in FlyBase by the symbol Dmel\NetB (CG10521, FBgn0015774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14581645..14643407. It has the cytological map location 12F2-12F3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; dendrite guidance. 24 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: multi-cell-component structure; nervous system; peripheral nervous system; organ system; adult segment; abdominal segmental nerve; axon; commissure; embryonic nervous system; cell projection; adult mesothoracic segment; embryonic foregut. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Netrin-B is referred to in FlyBase by the symbol Dmel\NetB (CG10521, FBgn0015774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14581645..14643407. It has the cytological map location 12F2-12F3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; dendrite guidance. 24 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: multi-cell-component structure; nervous system; peripheral nervous system; organ system; adult segment; abdominal segmental nerve; axon; commissure; embryonic nervous system; cell projection; adult mesothoracic segment; embryonic foregut. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Netrin-B is referred to in FlyBase by the symbol Dmel\NetB (CG10521, FBgn0015774). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14581645..14643407. It has the cytological map location 12F2-12F3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; salivary gland boundary specification; dendrite guidance. 24 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: multi-cell-component structure; nervous system; peripheral nervous system; organ system; adult segment; abdominal segmental nerve; axon; commissure; embryonic nervous system; cell projection; adult mesothoracic segment; embryonic foregut. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 793 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [ISS]
    proteinaceous extracellular matrix [IEA][ISS]
    Biological Process: motor axon guidance [IMP]
    salivary gland boundary specification [IMP]
    axon guidance [ISS][NAS]
    synaptic target attraction [TAS]
    dendrite guidance [IGI]
    Molecular Function: protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRATGTRMG LLLPIILALA IGSSAAGISS NDPCYFEGKP RKCLPSFVNA AYGNPVQASS  60
   61 VCGAQQPERY CELLRDGNAG ECRSCEQQRY GPAALTDLNN PSNVTCWRSG AVNVPHDPDS 120
  121 APPDNVTLTL SLGKKYELTY ISLSFCPRSP RPDSLAIFKS SDFGQTWQPF QFYSSQCQKF 180
  181 YGRPDRAKIS KFNEQEARCI NSQHDTGGAA QRFAFNTLEG RPSANDLDSS LVLQDWVTAT 240
  241 DIRVVFHRLE LPPQLLKVKN ANAFSDEMGG SREEDEDDDA DLELDGEQDE YDYNLQDNDS 300
  301 ADAGYDEYEE PKKHLELDDD HLHLDYASDG ESVVKRQGKH KGSAYEKHYQ SKLAATTPPQ 360
  361 QPPKVTPPGK VTPPSTAAPS AAASAVTLPI SQHYAVSDFA VGGRCKCNGH ASECVATVSS 420
  421 GSGTALSDQD DGQDEDTPSA PSLANHFGRS TQMSAKLTMT CACKHNTAGP ECERCKPFYF 480
  481 DRPWGRATDN DANECKMCQC NGHARRCRFN LELYKLSGRV SGGVCYNCQH DTTGRYCHYC 540
  541 REGYYRDATK PPNHRKVCKR CDCHPVGSTG KTCNHLSGQC PCKEGVTGLT CNRCARGYQQ 600
  601 TRSHVAPCIK VPTNANMIQA ESAGGGGGGG TGDYKDGGGS QVEEMKKYCG KCKASPKKLN 660
  661 LNKFCMEDYA ILAKVIGHDR ASQDISTEKF SIERQNEIYK YEINIQTIFK RNPMSGTTSS 720
  721 LLGRGNMMLL VPRKSIECQC PKIKLNKSYL ILGRDSEAAP GYLAIGPSSV VLEWKDEWSL 780
  781 RMKRFQRRAR KCS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..181] MSA 1.071985 View MSA. No confident structure predictions are available.
    2 View Details [182..250] deduced N/A No confident structure predictions are available.
    3 View Details [251..445] FFAS03 2.06 Crystal structure of Nidogen/Laminin Complex
    4 View Details [446..607] PSI-BLAST 8.0 Crystal structure of Nidogen/Laminin Complex
    5 View Details [608..793] FFAS03 4.66 Procollagen c-proteinase enhancer protein PCOLCE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • metalloendopeptidase inhibitor activity
    		•  2.93008814424574 bayes_pls_golite062009
  • metalloenzyme regulator activity
    		•  2.93008814424574 bayes_pls_golite062009
  • metalloenzyme inhibitor activity
    		•  2.93008814424574 bayes_pls_golite062009
  • cytokine activity
    		•  2.1026057983858 bayes_pls_golite062009
  • protein binding
    		•  1.99085018021326 bayes_pls_golite062009
  • chemokine activity
    		•  1.91192407750516 bayes_pls_golite062009
  • chemokine receptor binding
    		•  1.91192407750516 bayes_pls_golite062009
  • receptor binding
    		•  1.70988428101653 bayes_pls_golite062009
  • binding
    		•  1.55301582466033 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.33224850209979 bayes_pls_golite062009
  • endopeptidase inhibitor activity
    		•  1.31068274422963 bayes_pls_golite062009
  • peptidase inhibitor activity
    		•  1.26079752095237 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  1.2236133281236 bayes_pls_golite062009
  • integrin binding
    		•  0.387338090721027 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle